NURSING INTERVENTIONS FOR ACUTE ORAL PAIN AND MUCOSITIS

急性口腔疼痛和粘膜炎的护理干预

• 批准号: 2257953
• 负责人: DEBORAH B. MCGUIRE
• 金额: $ 27.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2257953
• 关键词: biomarker; bone marrow transplantation; cancer pain; clinical trials; coping; drug adverse effect; human subject; neoplasm /cancer chemotherapy; nursing education; nursing intervention; oncology nursing; oral facial pain; oral mucosa; psychological stressor; sign /symptom; statistics /biometry

Acute oral pain and mucositis secondary to intensive cytoreductive therapy for cancer are a significant problem for many patients, yet no systematic nursing research exists. Using a unique multidimensional conceptualization of cancer pain, the primary aim of this research is to test in a randomized, two-group clinical trial effects of a nurse- administered psychoeducational intervention on selected outcomes in adults diagnosed with hematologic or solid tumor malignancies. The hypothesis to be tested is that a nurse-administered psychoeducational intervention used in conjunction with pain and oral care practice standards will decrease severity and duration of acute oral pain and mucositis, decrease emotional distress, and increase the use of cognitiv and behavioral coping strategies. Three secondary aims are to: 1) explore the integrated and interactive nature of six dimensions of the experience of pain, 2) examine the effects of interventions on these dimensions of pain, and 3) examine relationships between pain-related biologic markers and clinical measures of acute oral pain and mucosal tissue injury. The project will be conducted on two inpatient nursing units at Emory University Hospital, Atlanta, GA, by a research team representing the disciplines of nursing, medicine, dentistry, biostatistics, pharmacy, and clinical psychology. Consenting patients will be randomly assigned to the control group (receiving usual nursing and medical care) or to the experimental group (receiving a psychoeducational intervention consisting of concrete objective information and coping skills training given prior to initiation of cytoreductive therapy, and reinforcement teaching done throughout hospitalization). Acute pain and oral care practice standards will be used to manage symptoms in both study groups. Pain, mucositis, and othe relevant data will be collected daily on all patients from admission through at least 21 days after initiation of therapy. Results will provide guidance for clinical nursing practice, increase understanding of the multidimensional experience of pain and its relationship with interventions, and provide a beginning understanding of biologic markers of pain and mucositis.

强化细胞减灭术继发的急性口腔疼痛和粘膜炎 癌症治疗对于许多患者来说是一个重大问题，但目前还没有 存在系统的护理研究。 使用独特的多维 癌痛的概念化，本研究的主要目的是 在随机、两组临床试验中测试护士的效果 对选定的结果进行心理教育干预 被诊断患有血液系统或实体瘤恶性肿瘤的成年人。 这 要检验的假设是护士管理的心理教育 与疼痛和口腔护理实践结合使用的干预措施 标准将减少急性口腔疼痛的严重程度和持续时间 粘膜炎，减少情绪困扰，增加认知能力的使用 和行为应对策略。 三个次要目标是：1) 探索六个维度的综合性和互动性 疼痛经历，2）检查干预措施对这些的影响 疼痛的维度，3）检查与疼痛相关的之间的关系 急性口腔和粘膜疼痛的生物标志物和临床测量 组织损伤。 该项目将在两个住院护理项目上进行 乔治亚州亚特兰大埃默里大学医院的一个研究小组 代表护理、医学、牙科等学科， 生物统计学、药学和临床心理学。 同意的患者 将被随机分配到对照组（接受常规护理 和医疗保健）或实验组（接受 心理教育干预包括具体目标 在开始之前进行信息和应对技能培训 细胞减灭治疗，全程强化教学 住院治疗）。 急性疼痛和口腔护理实践标准将 用于管理两个研究组的症状。 疼痛、粘膜炎等 从入院起每天都会收集所有患者的相关数据 治疗开始后至少 21 天。 结果将 为临床护理实践提供指导，增加理解 疼痛的多维体验及其与 干预措施，并提供对生物标志物的初步了解 疼痛和粘膜炎。