MELATONIN SUPPRESSION BY LIGHT IN AFFECTIVE DISORDER

情感障碍中光对褪黑激素的抑制

• 批准号: 3382769
• 负责人: John I Nurnberger
• 金额: $ 15.33万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3382769
• 关键词: bipolar depression; blood chemistry; circadian rhythms; clinical depression; genetic markers; hormone regulation /control mechanism; human subject; lighting; melatonin; posture; sleep disorders

Affective disorder appears to be strongly influenced by genetic factors. However, apart from recent DNA marker studies in certain families, particular biological markers of vulnerability have yet to be confirmed. Suppression of melatonin by light has been found to be unusually sensitive in a small number of medications. It appears to be similarly sensitive in some high-risk offspring of bipolars. Thus, it may be a trait marker for certain forms of affective disorder. This work requires replication in a new population. Using a case-control design, we propose to test melatonin suppression by light in euthymic bipolar patients, examine its relationship to baseline melatonin rhythms on a dark night in the same subjects, and compare light suppression in patients to that in controls for sex, age, and season of testing. Melatonin suppression will be measured by exposing subjects to 500 lux light between 2 A.M. and 4 A.M. and measuring plasma melatonin before and after the light stimulus. The study will be performed on a clinical research ward. We also propose to test reproducibility of the melatonin suppression response in volunteers and examine the effects of lithium on suppression in patients. A group of unipolar patients would also be tested to assess the response in another affective subgroup. These patients will also be compared with matched controls. Confirmation of a biologic vulnerability marker for bipolar illness and related affective conditions would be an important step in understanding their pathophysiology. It would also be potentially useful in genetic counselling for patients and their families.

情感障碍似乎受到遗传因素的强烈影响。 但是，除了某些家庭最近的DNA标记研究外， 脆弱性的特定生物标记尚未确认。 发现通过光抑制褪黑激素是异常敏感的 在少量药物中。它似乎同样敏感 一些高风险的双皮子后代。因此，它可能是特征标记 某些形式的情感障碍。 这项工作需要在新人群中复制。使用案例对照 设计，我们建议在正式中测试光线抑制褪黑激素 双极患者，检查其与基线褪黑激素节奏的关系 在同一主题中的漆黑夜晚，并比较 在性别，年龄和测试季节的对照中的患者。 褪黑激素抑制将通过暴露于500 lux的受试者来衡量 凌晨2点之间的光和凌晨4点并在之前测量血浆褪黑激素 光刺激后。该研究将在临床上进行 研究病房。 我们还建议测试褪黑激素抑制的可重复性 志愿者的反应并检查锂对抑制的影响 患者。 一组单极患者也将进行测试，以评估 另一个情感亚组。这些患者也将与 匹配的控件。 确认躁郁症的生物脆弱性标记和 相关的情感条件将是理解的重要一步 他们的病理生理学。它在遗传中也可能有用 为患者及其家人提供咨询。