Cerebral oscillations of pain

疼痛的大脑振荡

基本信息

批准号：
10442525
负责人：
Joyce Teixeira Da Silva
金额：
$ 38.55万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10442525
关键词：
Affect Alpha Rhythm Base of the Brain Behavioral Brain Cerebrum Clinical Cognition Cognitive Cognitive Therapy Data Development Disease Effectiveness Electroencephalogram Emotional Frequencies Functional Magnetic Resonance Imaging Future Genetic Goals Individual Intervention Knowledge Lead Left Link Literature Machine Learning Manuscripts Measures Modeling Molecular Neurobiology Pain Pain Research Pain intensity Pain management Pain-Free Painless Participant Patients Pattern Perception Persistent pain Persons Pharmaceutical Preparations Phase Predictive Factor Prefrontal Cortex Prognostic Marker Reproducibility Rest Rodent Model Sensitivity and Specificity Sensory Sensory Process Signal Transduction Societies Specificity Structure Task Performances Testing Therapeutic Intervention Work analytical tool blood oxygen level dependent chronic pain chronic pain management chronic painful condition cognitive function cognitive performance cognitive task cost effective intervention experience improved individualized medicine machine learning method mindfulness intervention neuroimaging new therapeutic target noninvasive brain stimulation novel novel therapeutic intervention novel therapeutics pain model pain sensitivity predictive marker psychosocial relating to nervous system side effect targeted treatment therapy development vector

项目摘要

Summary Chronic pain disorders are amongst the most burdensome of all diseases in terms of their impact on the individual and the costs to society. The development of novel therapeutic approaches for chronic pain have relied on basic studies involving genetic and molecular approaches in rodent models of pain, but existing drugs generally provide very limited relief for only a small number of patients. The result is that a vast number of people with chronic pain go untreated and have only partial relief. There is substantial and growing evidence from within and outside the pain research fields that indicates neural oscillations reflect cognitive, emotional, and sensory processes, which are all components of the pain experience. Furthermore, we can target these oscillatory patterns to alter perception. In particular, alpha band activity has been associated with chronic pain, and our extensive recent work and preliminary findings indicate that alpha can reliably predict future sensitivity to pain experienced minutes to weeks in the future in healthy subjects. In the proposed studies, we use simultaneous EEG-fMRI to continue our ongoing work on alpha oscillations as pain mechanisms and extend it to test the specificity and sensitivity of the signals and the relationship between alpha, brain networks, and pain. The proposed work would lead to improved understanding of the neurobiology of pain, identify novel brain targets for new or improved interventions, and potentially reveal a prognostic biomarker that would be useful for testing new therapeutic approaches and objectively assessing clinical improvement on an individual basis.

概括就其对身体的影响而言，慢性疼痛疾病是所有疾病中最严重的疾病之一。个人和社会的成本。慢性疼痛新治疗方法的发展依赖于涉及啮齿动物疼痛模型的遗传和分子方法的基础研究，但现有药物通常只能为少数患者提供非常有限的缓解。其结果是，大量的患有慢性疼痛的人得不到治疗，只能得到部分缓解。有大量且不断增加的证据来自疼痛研究领域内外的研究表明，神经振荡反映了认知、情感、和感觉过程，这些都是疼痛体验的组成部分。此外，我们还可以针对这些振荡模式来改变感知。特别是，α带活动与慢性疼痛有关，我们最近的大量工作和初步发现表明 alpha 可以可靠地预测未来的敏感性健康受试者在未来几分钟到几周内经历的疼痛。在拟议的研究中，我们使用同步脑电图-功能磁共振成像继续我们正在进行的关于阿尔法振荡作为疼痛机制的工作并扩展它测试信号的特异性和敏感性以及阿尔法、大脑网络和疼痛。拟议的工作将提高对疼痛神经生物学的理解，识别新的新的或改进的干预措施的大脑目标，并可能揭示一个预后生物标志物对于测试新的治疗方法和客观评估个体的临床改善很有用基础。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Fear and pain slow the brain.

恐惧和疼痛会使大脑变慢。

DOI：
10.1097/j.pain.0000000000003099
发表时间：
2023-10-26
期刊：
Pain
影响因子：
7.4
作者：
Ali Mazaheri;Andrew J. Furman;D. A. Seminowicz
通讯作者：
D. A. Seminowicz

Beyond pain in the brain: A clinician's guide to interpreting the spinal cord's role in the pain experience.

超越大脑的疼痛：临床医生解释脊髓在疼痛体验中的作用的指南。

DOI：
发表时间：
2022-12
期刊：
影响因子：
0
作者：
Margerison, Sarah M;Westlake, Kelly P;Seminowicz, David A
通讯作者：
Seminowicz, David A

Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.

病理性屏状核活动驱动人类慢性疼痛的异常认知网络处理。

DOI：
发表时间：
2023-11-02
期刊：
影响因子：
0
作者：
Stewart, Brent W;Keaser, Michael L;Lee, Hwiyoung;Margerison, Sarah M;Cormie, Matthew A;Moayedi, Massieh;Lindquist, Martin A;Chen, Shuo;Mathur, Brian N;Seminowicz, David A
通讯作者：
Seminowicz, David A