MODELING TRANSFER AND BIOACCUMULATION OF METALS IN AQUATIC FOOD WEBS

水生食物网中金属的转移和生物累积建模

• 批准号: 3840784
• 负责人: ROBERT V. THOMANN
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3840784
• 关键词: Annelida; Malacostraca; aquatic organism; cadmium; chromium; diffusion; environmental toxicology; fish; food chain contamination; mathematical model; methylmercury; model design /development; seafood poisoning; soil pollution; toxicant interaction; water environment; water pollution; water sampling /testing

This research is directed towards developing predictive models of the fate and accumulation of metals in benthic aquatic animals (e.g., crab, lobster, and benthic fishes) that are consumed by humans and may therefore represent an increased risk to public health. Metals released from Superfund sites may be stored in the sediments to elevated concentrations thereby representing a route of potentially higher doses of metals to humans than from drinking water. Also, the benthic biomass may significantly influence the time of recovery and bioavailability of metals at a site due to sediment mixing (bioturbation). With calibrated predictive modeling tools available, a more credible basis can then be established for estimating the effectiveness of remedial actions. The specific aims of this research are to: (1) construct a generic model of metal accumulation in aquatic food webs with sediment interaction, (2) develop physiologically based toxicokinetic models of uptake and disposition of metals in benthic animals, (3) develop a modeling framework for the effect of sediment bioturbation due to benthic biomass on the flux of cadmium from sediments, and (4) apply the fate and accumulation modeling framework to cadmium in the blue crab of a Superfund site at Foundry Cove. These models will be calibrated using: (1) existing data from Superfund and other sites for the generic model of metals transfer, (2) laboratory data to be obtained by other components on Cd uptake in benthic invertebrates and Cd disposition in blue crab, Atlantic tomcod and killifish for use in the generic model and the PB-TK modeling, (3) data from measurements of Cd flux in the laboratory with varying densities of benthic biomass to develop the model of Cd flux due to bioturbation and (4) existing data to be supplemented by field work at Foundry Cove to calibrate the modeling framework of Cd in the blue crab under field conditions.

这项研究针对发展命运的预测模型 和金属在底栖水产动物中的积累（例如蟹，龙虾， 和人类消耗的底栖鱼），因此可能代表 公共卫生风险增加。 超级基金网站释放的金属 可以将其存储在沉积物中至升高的浓度 代表可能比人类的可能更高剂量的金属的途径 从饮用水。 而且，底栖生物量可能会显着影响 由于 沉积物混合（生物扰动）。 使用校准的预测建模工具 可用，可以建立更可信的基础，以估算 补救措施的有效性。 这项研究的具体目的是：（1）构建通用模型 与沉积物相互作用的水生食物网中的金属积累，（2） 开发基于生理的毒素摄取模型和 底栖动物中金属的处置，（3）开发建模框架 为了由于底栖生物量而对磁通产生的沉积物生物扰动的影响 来自沉积物的镉，（4）应用命运和积累建模 在Foundry Cove的超级基金地点的蓝蟹中镉的框架。 这些模型将使用以下方式校准：（1）超级基金的现有数据 以及金属转移通用模型的其他站点，（2）实验室 底栖的其他组件在CD吸收上要获得的数据 蓝蟹，大西洋tomcod和CD处置 killifish用于通用模型和PB-TK建模，（3）数据 从实验室中CD通量的测量值不同 底栖生物量以生物扰动而开发CD通量模型和（4） 现有数据将通过Foundry Cove的现场工作补充以校准 在野外条件下，蓝蟹中CD的建模框架。