NEUROTOXICOLOGY OF SUPERFUND CHEMICALS

SUPERFUND 化学品的神经毒理学

• 批准号: 3104532
• 负责人: HERBERT E LOWNDES
• 金额: $ 111.48万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1995-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3104532
• 关键词: environmental toxicology; industrial waste; lead poisoning; neurotoxins; nonwater solvent

This application, prepared in response to RFA ES-91-02, will address the need for additional studies on neurological and behavioral aspects of chemicals commonly found in Superfund dumpsites. Research focus within the eight multidisciplinary projects of the program will be achieved by addressing specifically the neurotoxicity of selected solvents (trichloroethylene, monochloroacetic acid, related halogenated hydrocarbons) and metals (lead). Projects have been designed to examine: 1. the hydrogeology of solvents. 2. the neurotoxicity of solvents at the biochemical/cellular levels. 3. the neurotoxicity of lead on developing and adult neuronal systems. 4. the ecological and human neurobehavioral responses to lead and solvents. 5. engineering approaches to the biological treatment of Superfund contaminants. These studies will be conducted by members of the Environmental and Occupational Health Sciences Institute, a research institute comprising investigators from Rutgers, The State University of New Jersey and R.W. Johnson Medical School, The University of Medicine and Dentistry of New Jersey.

该应用程序是根据RFA ES-91-02响应的，将解决 需要关于神经和行为方面的其他研究 在超级基金垃圾场中常见的化学物质。 研究重点 该计划的八个多学科项目将由 专门针对选定溶剂的神经毒性 （三氯乙烯，单氯乙酸，相关的卤素 碳氢化合物）和金属（铅）。 项目旨在检查： 1。溶剂的水文地质学。 2。在生化/细胞水平上溶剂的神经毒性。 3。铅神经毒性在发育和成人神经元系统中。 4。对铅和溶剂的生态和人类神经行为反应。 5。超级基金生物处理的工程方法 污染物。 这些研究将由环境成员进行 职业健康科学研究所，一家研究所 罗格斯，新泽西州立大学和R.W.的调查人员 约翰逊医学院医学大学和牙科 球衣。