Making data accessible: a rebuild and expansion of BrainRNAseq.org

使数据可访问：BrainRNAseq.org 的重建和扩展

• 批准号: 10432818
• 负责人: Shane Liddelow
• 金额: $ 8.74万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10432818
• 关键词: Advertising; Advocate; Age; Algorithms; Back; Code; Communities; Consult; Country; Custom; Data; Data Set; Databases; Development; Engineering; Ensure; Esthetics; Faculty; Feedback; Future; Gene Expression; Home; Human; Individual; Intention; Internet; Light; Link; Medical Students; Mus; Neurosciences; Output; Paralysed; Proteomics; Resources; Scientist; Series; Side; Site; Software Engineering; Source; Standardization; Time; Training; Vision; Walking; Work; cell type; data acquisition; data sharing; design; experience; interest; meetings; metabolomics; posters; repaired; repository; searchable database; tool; transcriptome sequencing; transcriptomics; user-friendly; web app; web site

Project Summary Big datasets are now a routine output for many studies. A corollary of this reality is the ever-growing need to disseminate this information to other scientists, a feat that presents its own challenges. Over 7 years ago, we found ourselves grappling with these very questions because we had generated a series of mouse and human datasets that we felt would greatly benefit the glial (and greater neuroscience) community. After many iterations, we developed a website called BrainRNAseq.org, a central source where other scientists could easily and quickly access our data—whether they were browsing at home, or while walking down the poster aisle at a meeting. Over time, this website has become a staple within our scientific community and currently garners over 250 users per day, with over 56,000 different users in the past 3 years alone. However, the site is in need of back-end repairs to ensure its utility for the foreseeable future. In the first aim of this proposal, we will rebuild the site while maintaining its user interface and adding user-requested upgrades. Our second aim is to build a free application that will enable other creators to build similar sites with ease. Creators will need no coding experience—only a .csv file with their data, and our application (Dataspectra 2.0) will provide a suite of simple aesthetic options to construct a user-friendly website where others can explore and download their data. Finally, to consolidate the growing number of datasets currently scattered across the web, we will create “Barreseq”—a central repositiory for glial datasets where trainees and faculty and quickly apply filters (species, data type, age, etc) to identify relevant datasets for their specific interests. We envision a paradigm in which data sharing moves towards standardization. We want to build the tools necessary to lower the activation energy for individuals to share their data, and to do so in a mechanism that is visually familiar and digestible to other users. We believe that this will strengthen our scientific community, both in terms of generating stronger hypotheses, and in the spirit of more easily sharing the valuable resources that everyone is producing.

项目概要 现在，大数据集已成为许多研究的常规输出。这一现实的必然结果是，对大数据集的需求不断增长。 将这些信息传播给其他科学家，这一壮举在七年前就面临着挑战。 我们发现自己正在努力解决这些问题，因为我们已经生成了一系列小鼠和人类模型 经过多次迭代后，我们认为这些数据集将极大地有益于神经胶质（和更大的神经科学）社区。 我们开发了一个名为 BrainRNAseq.org 的网站，这是一个中心来源，其他科学家可以轻松地通过该网站获取信息。 快速访问我们的数据——无论他们是在家浏览，还是在海报走道上行走时 随着时间的推移，该网站已成为我们科学界的主要内容，目前已获得超过 每天有 250 个用户，仅过去 3 年就有超过 56,000 个不同的用户。但是，该网站仍然需要。 后端修复以确保其在可预见的将来的实用性 在该提案的第一个目标中，我们将重建它。 网站，同时维护其用户界面并添加用户请求的升级。我们的第二个目标是建立一个免费的。 应用程序将使其他创建者能够轻松构建类似的网站，创建者无需编码。 经验 - 只需一个包含数据的 .csv 文件，我们的应用程序 (Dataspectra 2.0) 将提供一套简单的 最后，构建一个用户友好的网站，其他人可以探索和下载他们的数据。 为了整合目前散布在网络上的越来越多的数据集，我们将创建“Barreseq”——一个 神经胶质数据集的中央存储库，学员和教师可以在其中快速应用过滤器（物种、数据类型、年龄、 等）来识别适合他们特定兴趣的相关数据集。我们设想了一种数据共享的范式。 我们希望建立必要的工具来降低个人的激活能。 共享他们的数据，并以其他用户视觉上熟悉且易于理解的机制来实现这一点。 这将加强我们的科学界，无论是在产生更有力的假设方面，还是在 更轻松地共享每个人正在生产的宝贵资源的精神。