Clinical Research & Patient Care Core (CRPCC)

临床研究

基本信息

批准号：
10431471
负责人：
Larry S. Schlesinger
金额：
$ 19.99万
依托单位：
TEXAS BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-10 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10431471
关键词：
Address Ambulatory Care Facilities Biomedical Research Caring Cause of Death Chest Cities Clinic Clinical Clinical Management Clinical Research Clinical Services Collection Communicable Diseases Communication Communities Complex Consultations Country Custom Data Data Analyses Development Diabetes Mellitus Discipline Education Educational Curriculum Enrollment Epidemiology Ethics Evaluation Extreme drug resistant tuberculosis Field Workers Foundations Funding Funding Agency Future Health Health Professional Homelessness Hospitals Human Subject Research Hybrids Incidence Infrastructure Inpatients Institutes Institution Knowledge Laboratories Leadership Learning Length of Stay Logistics Medical Mentors Mexican Mexico Mission Multidrug-Resistant Tuberculosis Non-Insulin-Dependent Diabetes Mellitus Oral Outpatients Participant Pathogenesis Patient Care Patients Persons Physicians Pilot Projects Population Prevention strategy Qualitative Evaluations Quantitative Evaluations Research Research Design Research Institute Research Personnel Research Training Resources Rotation Science Side Site Social Problems South Texas Specimen Specimen Handling Structure Texas Thoracic Radiography Training Treatment outcome Tuberculosis Universities Vaccines Work biocontainment facility clinical care clinical center clinical research site comorbidity critical period curriculum enhancement design diagnostic strategy experience field study human old age (65+)improved interdisciplinary approach interdisciplinary curriculum interest laboratory experiment member metropolitan multidisciplinary next generation peer prevent programs prospective research study skills social success therapy adverse effect tool transmission process treatment strategy tuberculosis diagnostics tuberculosis treatment virtual

项目摘要

IN-TRAC Clinical Research & Patient Care Core (CRPCC) ABSTRACT Tuberculosis (TB) is a leading infectious disease cause of death worldwide. In the US, TB incidence rates are historically low, but control remains challenging in certain populations, including the communities along the US border with Mexico. Thus, there is an urgent need for the next generation of TB researchers to have an understanding of the clinical and epidemiological aspects of TB research, as a foundation for their future leadership in the development of improved TB diagnostics, surveillance, treatments and vaccines. The Clinical Research & Patient Care Core (CRPCC) of the IN-TRAC will provide to New TB Investigators (NIs) and investigators new to the TB field, the infrastructure, resources and training in TB clinical research, and education on the challenges faced by clinicians in managing TB cases. Our training sites are strategically located in south Texas, a state adjacent to Mexico, which is the number one country of origin for foreign-born TB cases in the US. The TB clinical research site is led by Dr. Restrepo, an expert in TB field epidemiology and pathogenesis in TB patients with diabetes comorbidity or old age. Her field site is unique within the US due to its access to TB patients enrolled on the Mexican side of the Texas border. The TB patient care training will be in San Antonio, led by Drs. Armitige and Seaworth, an exemplary team of physicians who are affiliated with the only free-standing TB hospital in the US, the Texas Center for Infectious Diseases (TCID). In the same setting, there are also busy outpatient clinics: The San Antonio Metropolitan Health Department Chest Clinic, and a TB regional training and medical consultation Center of Excellence (The Heartland National TB Center; HNTBC). Our Aims are to: Aim 1. Execute a personalized training curriculum on TB clinical research studies. We have designed a hybrid (hands-on and virtual) training curriculum for IN-TRAC participants on all aspects of Clinical TB Research, including ethics, study design, field logistics, data and specimen management, specimen processing and data analysis plans and communications. Aim 2. Execute a personalized training curriculum on TB patient care. IN-TRAC participants will be educated on the complex set of decisions that physicians make, particularly during the management of difficult TB cases (e.g. with DR-TB, or with social problems such as homelessness), and who require specialized management and prolonged in-hospital stays. The mentoring team will meet with each IN-TRAC participant prior to their rotation to discuss customization of the core curriculum, including the development of a pilot project, depending on the IN-TRAC participant’s interest. IN-TRAC participants will provide a written and oral evaluation of their training experience.

IN-TRAC 临床研究和患者护理核心 (CRPCC) 摘要结核病 (TB) 是全球主要的传染病死因。在美国，结核病发病率高达 90%。处于历史低位，但对某些人群（包括美国沿线社区）的控制仍然具有挑战性因此，迫切需要下一代结核病研究人员拥有一个了解结核病研究的临床和流行病学方面，作为他们未来的基础在改进结核病诊断、监测、治疗和疫苗开发方面发挥领导作用。 IN-TRAC 的研究与患者护理核心 (CRPCC) 将为新结核病研究者 (NI) 和结核病领域的新研究者、结核病临床研究和教育方面的基础设施、资源和培训我们的培训地点战略性地位于南部。德克萨斯州，毗邻墨西哥，是美国外国出生结核病病例的第一大原产国美国结核病临床研究中心由美国结核病领域流行病学和发病机制专家 Restrepo 博士领导。患有糖尿病合并症或老年的结核病患者由于能够接触到结核病，因此在美国是独一无二的。在德克萨斯州边境墨西哥一侧参加的结核病患者护理培训将在圣安东尼奥举行。由 Armitage 和 Seaworth 博士领导，这是一支模范医生团队，隶属于唯一的独立机构美国的结核病医院、德克萨斯州传染病中心（TCID）也同样忙碌。门诊诊所：圣安东尼奥市卫生局胸部诊所以及结核病区域培训和卓越医疗咨询中心（哈特兰国家结核病中心；HNTBC）。 1. 执行结核病临床研究的个性化培训课程我们设计了一个混合课程。为 IN-TRAC 参与者提供有关临床结核病研究各个方面的（实践和虚拟）培训课程，包括伦理、研究设计、现场后勤、数据和样本管理、样本处理和数据目标 2. 执行结核病患者护理的个性化培训课程。 IN-TRAC 参与者将接受有关医生做出的一系列复杂决策的教育，特别是在疑难结核病病例的管理（例如耐药结核病或无家可归等社会问题），以及需要专门管理和长期住院的人。指导团队将在每位 IN-TRAC 参与者轮换之前与他们会面，讨论定制化方案核心课程，包括开发试点项目，具体取决于 IN-TRAC 参与者的兴趣。 IN-TRAC 参与者将对他们的培训经历进行书面和口头评估。