Core 4: Pilot Project Core

核心 4：试点项目核心

• 批准号: 10429950
• 负责人: MICHAEL F MILES
• 金额: $ 13.97万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10429950
• 关键词: Acute; Advisory Committees; Affect; Alcohol abuse; Alcohol consumption; Amides; Applications Grants; Cannabinoids; Clinical Trials; Cognitive; Conflict (Psychology); Data; Dependence; Development; Dissection; Drug Modelings; Drug abuse; Drug usage; Emotions; Enzymes; FAAH inhibitor; Fatty Acids; Funding; Future; Genetic; Genetic Markers; Genetic study; Goals; Grant; Human; Individual; Intake; Intoxication; Investigation; Knock-out; Knowledge; Laboratories; Lead; Lipids; Metabolic; Modeling; Molecular; Motivation; NAPE-PLD; Neurocognition; Neurocognitive; Online Systems; PPAR alpha; PPAR gamma; Participant; Pathway interactions; Performance; Pharmaceutical Preparations; Phase; Phenotype; Pilot Projects; Population Heterogeneity; Postdoctoral Fellow; Quality Control; Rattus; Research; Research Personnel; Risk; Role; Sampling; Signal Transduction; Solid; Standardization; Students; Testing; Training Support; Work; alcohol behavior; alcohol research; alcohol response; alcohol risk; alcohol sensitivity; alcohol use disorder; base; cognitive performance; comorbidity; disorder risk; executive function; experience; fatty acid amide hydrolase; gene network; genomic data; inhibitor; innovation; interest; neurobehavioral; novel; parent grant; preference; programs; synthetic enzyme; training opportunity

Project Summary – Pilot Projects The goals of this Pilot Project Core of the VCU Alcohol Research Center are to: 1) manage the progress and quality control for our two designated initial pilot projects, 2) solicit and evaluate future pilot grant proposals to further expand the scientific breadth of VCU-ARC, 3) encourage pilot grant awardees to submit proposals for independent funding and 4) support training opportunities for students and postdoctoral fellows within laboratories of funded pilot projects. Drs. Bjork and Edwards are experts in motivational and internalizing factors that influence risk for human alcohol use disorders (AUDs) and will be the Lead and co-investigator of Pilot Project 1, entitled “The role of neurocognition in polygenic risk for alcohol use disorder and comorbidities”. They have proposed a novel study to integrate data on the neurocognitive performance of individuals with severe AUD and uncover the genetic relationships leading to AUD risk. Their pilot will interface with the longitudinal genetic studies proposed in Projects 4 and 5 (Dick and Webb) and may inform analyses in Core 3 (Bacanu). Furthermore, if successful, Pilot Project 1's work will provide solid preliminary data for future funding applications assessing the neurocognitive and genetic contributions to risk for AUD. The second targeted pilot will be conducted by Dr. Joel Schlosburg, an expert neuropharmacologist with expertise in drug and alcohol use disorders, and is entitled "Dissection of the acute and dependent responses to ethanol in rats lacking fatty acid amide hydrolase”. Pilot Project 2 will use a newly established FAAH knockout rat on an outbred background to test the role of FAAH on ethanol sensitivity, intake and preference. This pilot will expand the knowledge of the impact of potential future FAAH inhibitor development for use in clinical trials, with at least three separate such inhibitors in various phases and endpoints. These studies may also be the first to demonstrate whether NAPE-PLD is the primary synthetic enzyme supplying fatty acid amide substrates to FAAH. We will solicit other proposals in year 2 and fund the two best of them in years 3-4, then solicit proposals again in year 4 to fund one in year 5. The pilot program is an important component of the VCU-ARC that will enable us to attract new and innovative researchers to interact with Center investigators and expand high quality alcohol research at VCU.

项目摘要 - 试点项目 VCU 酒精研究中心试点项目的核心目标是：1) 管理进度并 我们两个指定的初始试点项目的质量控制，2) 征求并评估未来的试点拨款提案 进一步扩大 VCU-ARC 的科学广度，3）鼓励试点拨款获得者提交提案 独立资助和4）支持学生和博士后研究员的培训机会 比约克博士和爱德华兹博士是激励和内化方面的专家。 影响人类酒精使用障碍（AUD）风险的因素，并将成为该项目的首席研究员和联合研究员 试点项目 1，题为“神经认知在酒精使用障碍和合并症的多基因风险中的作用”。 他们提出了一项新颖的研究，整合患有以下疾病的个体的神经认知表现数据： 严重的 AUD 并揭示导致 AUD 风险的遗传关系。 项目 4 和 5（Dick 和 Webb）中提出的纵向遗传学研究可能为核心 3 中的分析提供信息 （Bacanu）此外，如果成功，试点项目 1 的工作将为未来的资助提供可靠的初步数据。 评估神经认知和遗传对 AUD 风险的影响的应用程序 第二个目标试点。 由 Joel Schlosburg 博士主持，他是一位在药物和酒精方面具有专业知识的神经药理学家 使用障碍，标题为“缺乏脂肪的大鼠对乙醇的急性和依赖性反应的剖析” 试点项目 2 将使用新近建立的 FAAH 基因敲除大鼠进行近交。 测试 FAAH 对乙醇敏感性、摄入量和偏好的作用的背景 该试点将扩大范围。 了解未来潜在的 FAAH 抑制剂开发用于临床试验的影响，至少 这些研究也可能是第一个在不同阶段和终点进行的三个独立的此类抑制剂的研究。 证明 NAPE-PLD 是否是提供脂肪酸酰胺底物的主要合成酶 FAAH 将在第 2 年征求其他提案，并在第 3-4 年资助其中最好的两个提案，然后征求 第 4 年再次提议为第 5 年的一项资助。该试点计划是 VCU-ARC 的重要组成部分 这将使我们能够吸引新的和创新的研究人员与中心研究人员互动并扩大 弗吉尼亚联邦大学 (VCU) 的高质量酒精研究。