Arbovirus Prediction and Mitigation in the Indo-Pacific

印度-太平洋地区的虫媒病毒预测和缓解

基本信息

批准号：
10429130
负责人：
Joelle Ivy Rosser
金额：
$ 19.33万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10429130
关键词：
5 year old Address Aedes Arbovirus Infections Arboviruses Blood Circulation Blood specimen Breeding Chikungunya fever Child Climate Collection Communicable Diseases Communities Country Culicidae Custom Data Dengue Dengue Fever Dengue Infection Development Plans Diagnostic Disease Disease Outbreaks Drainage procedure Droughts Emerging Communicable Diseases Enrollment Environment Environmental Risk Factor Enzyme-Linked Immunosorbent Assay Epidemiology Evaluation Exposure to Fiji Floods Foundations Future Goals Habitats Hot Spot Household Image Immunoglobulin G Incidence Indonesia Infection Infectious Disease Epidemiology Infrastructure Insecticides Interdisciplinary Study Intervention Island Knowledge Laboratories Life Life Cycle Stages Light Measures Mentorship Modeling Modification Nested Case-Control Study Pacific Islands Pathway interactions Pattern Physicians Randomized Controlled Trials Research Resistance Risk Risk Factors Running Serology test Site Slum Source Surveillance Modeling Surveys System Testing Training Tropical Medicine Vaccines Water World Health Organization Yellow fever virus ZIKA Zika Virus base career career development chikungunya chikungunya infection climate change climate data cost design disease transmission experience global health high risk infection rate infectious disease model innovation mathematical model novel predictive modeling programs prototype seropositive transmission process vector control water environment zika fever

项目摘要

Project Summary / Abstract Dengue, a potentially life-threatening disease, has increased 30-fold in the last 50 years. In Indonesia, 1 in 3 children have had a dengue infection by 5 years old. Islands in the Indo-Pacific are highly vulnerable to climate change and water insecurity, two key drivers of arbovirus spread. Predicting and mitigating arbovirus transmission in the Indo-Pacific is critical to addressing the increasing risk of arboviruses in the U.S. In the next several decades, half the U.S. may have habitat suitable for Aedes aegypti and Ae. albopictus, mosquitos which spread dengue, chikungunya, Zika, and yellow fever viruses. Revitalizing Informal Settlements and their Environments (RISE) is a cluster randomized control trial evaluating the benefits of upgrading local water infrastructure in urban slums in Indonesia and Fiji. The RISE intervention is a prototype for future slum upgrading to address climate change and water insecurity throughout the Indo- Pacific. Although the World Health Organization recommends permanent environmental modification as an arbovirus control strategy, this has never before been rigorously tested. RISE provides an important opportunity to evaluate whether this model decreases or inadvertently increases arbovirus transmission. In addition to evaluating a new paradigm for mitigating arbovirus transmission, RISE is an ideal platform to assess gaps in knowledge about environmental drivers of arbovirus transmission. My hypothesis is that modifiable environmental conditions drive arbovirus transmission in these communities. To test this hypothesis, I will leverage the RISE platform to study arbovirus risk factors in this region and evaluate the impact of permanent environmental modification on arbovirus transmission in urban slums. I will also create a mathematical model to simulate arbovirus transmission in this region under a range of climate change and intervention scenarios. I have developed a customized career development plan that aligns with my proposed research. It incorporates both formal and informal training under the mentorship of Drs. LaBeaud and Luby. This training plan draws upon my existing expertise in global health, tropical medicine, and epidemiology; it will enhance my expertise in laboratory diagnostics, geospatial analysis, and mathematical modeling. The planned didactics and technical training included here will provide the foundation necessary to achieve my goal of becoming an academic physician focused on mitigating the spread of infectious diseases in the era of climate change.

项目概要/摘要登革热是一种可能危及生命的疾病，在过去 50 年中发病率增加了 30 倍。在印度尼西亚，三分之一儿童在 5 岁时感染过登革热。印度太平洋岛屿极易受到气候影响变化和水不安全是虫媒病毒传播的两个关键驱动因素。预测和减轻虫媒病毒印度-太平洋地区的传播对于解决美国日益增加的虫媒病毒风险至关重要几十年来，美国一半的地区可能拥有适合埃及伊蚊和伊蚊的栖息地。白纹伊蚊, 蚊子它们传播登革热、基孔肯雅热、寨卡病毒和黄热病病毒。振兴非正式住区及其环境 (RISE) 是一项整群随机对照试验，旨在评估印度尼西亚和斐济城市贫民窟当地供水基础设施升级的好处。 RISE 干预是未来贫民窟升级的原型，旨在解决印度整个地区的气候变化和水不安全问题太平洋。尽管世界卫生组织建议永久性环境改造作为虫媒病毒控制策略，这以前从未经过严格测试。 RISE 提供了一个重要的有机会评估该模型是否减少或无意中增加虫媒病毒传播。除了评估减轻虫媒病毒传播的新范例之外，RISE 也是一个理想的平台评估有关虫媒病毒传播的环境驱动因素的知识差距。我的假设是可改变的环境条件推动了虫媒病毒在这些社区的传播。为了检验这个假设，我将利用RISE平台研究该地区的虫媒病毒风险因素并评估其影响对城市贫民窟虫媒病毒传播的永久性环境改造。我还将创建一个模拟该地区在一系列气候变化和条件下虫媒病毒传播的数学模型干预场景。我制定了一个与我提议的研究相一致的定制职业发展计划。它包含在博士的指导下进行正式和非正式的培训。拉博和卢比。本次培训计划绘制基于我在全球健康、热带医学和流行病学方面现有的专业知识；它将提高我的专业知识实验室诊断、地理空间分析和数学建模。计划的教学和技术这里包含的培训将为我实现成为一名学者的目标提供必要的基础医生专注于在气候变化时代减轻传染病的传播。