Molecubes PET/CT system

Molecubes PET/CT 系统

• 批准号: 10428308
• 负责人: Weiguo Lu
• 金额: $ 59.99万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10428308
• 关键词: Animals; Biomedical Research; Computed Tomography Scanners; Core Facility; Cyclotrons; Devices; Disease Progression; Emission-Computed Tomography; Ensure; Equipment; Funding; Future; Generations; High Resolution Computed Tomography; Image; Infrastructure; Institution; Intuition; Isotopes; Magnetic Resonance Imaging; Medical center; Minor; Monitor; Positron-Emission Tomography; Production; Radiation; Radiation Physics; Radiation exposure; Radiochemistry; Request for Proposals; Research; Research Institute; Research Personnel; Resource Sharing; Scanning; Services; Small Animal Imaging Systems; System; Techniques; Technology; Texas; Tracer; United States National Institutes of Health; Universities; X-Ray Computed Tomography; animal facility; animal imaging; cancer prevention; cost; design; germ free condition; image guided; imaging capabilities; imaging modality; improved; in vivo imaging; instrument; light weight; multimodality; novel; operation; optical imaging; pre-clinical; pre-clinical research; programs; radiation delivery; user-friendly

ABSTRACT This proposal requests funds to acquire a new state-of-the-art MOLECUBES small animal imaging system with Positron Emission Tomography (PET) and Computed Tomography (CT) capabilities to support pre-clinical research at the University of Texas Southwestern Medical Center (UTSW). This multi-modality system includes the highest sensitivity PET system commercially available and a high-resolution CT for routine animal imaging with low radiation exposure. This equipment is selected compared to other commercially available scanners, also because of its compact size and light weight, user-friendly interface and intuitive workflow, high- throughput imaging capability, modular design enabling future expandability, as well as compatibility with other existing devices. UTSW has a long and successful record of accomplishment in conducting ground-breaking biomedical research. Many projects significantly benefit from in vivo imaging to acquire structural and functional information. Especially with the establishment of Cyclotron and Radiochemistry Program offering onsite production of novel PET tracers, a UTSW program funded by the Cancer Prevention and Research Institute of Texas (CPRIT), desire for pre-clinical PET/CT imaging has been growing substantially because of more scanning opportunities, access to short-lived isotopes, more types of isotopes for expanded research endeavors, and reduced costs associated with isotope transport from elsewhere. Nonetheless, currently there is only one PET/CT scanner in UTSW, which employed older-generation PET/CT technologies and cannot meet the technical needs in imaging quality and scanning efficiency. More critically, this scanner is located outside the Specific-pathogen-free animal facility, substantially limiting scope of projects behind the animal barrier, e.g. those using immuno-deficient animals, and prohibiting studies requiring multiple PET/CT scans, e.g. for longitudinally monitoring disease progression. The requested PET/CT will be installed in and managed by PreClinical Radition Core Facility (PCRCF) of UTSW located behind the animal barrier, a CPRIT-funded shared resource facility for in vivo imaging and radiation technologies and services. This setting allows maximally taking advantages of existing instrument and management infrastructure of the PCRCF to provide users a one-stop solution to access all major imaging modalities (PET/CT/MR/Optical imaging) and radiation delivery techniques (image-guided small animal irradiator), as well as extensive imaging and radiation physics expertise. To demonstrate the need for the requested PET/CT, we have assembled Major and Minor user groups. Their diverse spectrum of projects, majority of which funded by the NIH, ensures adequate use of the equipment. We have formed an Advisory Board to oversee the PET/CT operation and developed a sustainable financial plan. The requested instrument will meet a significant need of our institution for state-of-the-art in vivo imaging behind the animal barrier. It will improve accuracy and efficiency of projects it supports, as well as open new opportunities for our investigators.

抽象的 该提案要求资金购买一种新的最先进的 MOLECUBES 小动物成像系统 正电子发射断层扫描 (PET) 和计算机断层扫描 (CT) 功能支持临床前 德克萨斯大学西南医学中心（UTSW）的研究。这个多模态系统包括 市售最高灵敏度 PET 系统和用于常规动物成像的高分辨率 CT 辐射暴露量低。与其他市售扫描仪相比，选择此设备， 还因其尺寸紧凑、重量轻、用户友好的界面和直观的工作流程，高 吞吐量成像能力、模块化设计可实现未来的可扩展性以及与其他设备的兼容性 现有设备。 UTSW 在开展突破性的项目方面拥有长期成功的记录 生物医学研究。许多项目显着受益于体内成像来获取结构和 功能信息。特别是随着回旋加速器和放射化学课程的建立 现场生产新型 PET 示踪剂，这是由癌症预防和研究资助的 UTSW 项目 德克萨斯研究所 (CPRIT)，由于以下原因，对临床前 PET/CT 成像的需求大幅增长 更多扫描机会、获得短寿命同位素、更多类型的同位素用于扩展研究 努力，并降低与从其他地方运输同位素相关的成本。尽管如此，目前有 是 UTSW 仅有的一台 PET/CT 扫描仪，它采用了老一代 PET/CT 技术，无法 满足成像质量和扫描效率的技术需求。更关键的是，这个扫描仪位于 在无特定病原体的动物设施之外，大大限制了动物背后的项目范围 障碍，例如使用免疫缺陷动物，并禁止需要多次 PET/CT 扫描的研究， 例如用于纵向监测疾病进展。所请求的 PET/CT 将安装并管理 由位于动物屏障后面的 UTSW 临床前放射核心设施 (PCRCF) 进行，这是一个由 CPRIT 资助的项目 体内成像和辐射技术和服务的共享资源设施。此设置允许 最大限度地利用PCRCF现有的仪器和管理基础设施来提供 为用户提供访问所有主要成像模式（PET/CT/MR/光学成像）和辐射的一站式解决方案 传递技术（图像引导小动物辐照器），以及广泛的成像和辐射物理学 专业知识。为了证明对所要求的 PET/CT 的需求，我们聚集了主要和次要用户 组。他们的项目多种多样，其中大部分由 NIH 资助，确保充分利用 设备。我们成立了一个顾问委员会来监督 PET/CT 运营，并制定了可持续发展计划 财务计划。所需的仪器将满足我们机构对最先进的体内技术的重大需求 动物屏障后面的成像。它将提高其支持的项目的准确性和效率，以及 为我们的调查人员提供新的机会。