Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomes

大学橄榄球运动员累积头部撞击暴露 (HIE) 对 mTBI 发生率和 mTBI 后健康结果的影响

• 批准号: 10420062
• 负责人: Jaroslaw Harezlak
• 金额: $ 37.08万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420062
• 关键词: Acceleration; Accident and Emergency department; Accounting; Acute; Address; Athletic; Biomechanics; Brain; Brain Concussion; Characteristics; Clinical; Computers; Data; Data Set; Education; Enrollment; Equilibrium; Excision; Exposure to; Frequencies; Goals; Head; Health; Human; Incidence; Individual; Injury; Intervention; Literature; Manufactured football; Measurement; Measures; Medical; Medical Staff; Modeling; Modernization; Outcome; Personality Traits; Play; Policies; Positioning Attribute; Protective Devices; Public Health; Recording of previous events; Recovery; Reporting; Research; Risk; Risk Factors; Rotation; Safety; Seasons; Series; Severities; Sports; Statistical Methods; Statistical Models; Symptoms; System; Techniques; Testing; Time; Training; United States; base; cognitive function; college; contact sports; demographics; head impact; high school; improved; injury prevention; innovation; machine learning method; mild traumatic brain injury; prediction algorithm; prototype; tool

Project Abstract Sport-related concussion (SRC) is a significant public health problem resulting in over 200,000 annual trips to the Emergency Department (ED) in the United States with as many as 3.8 million SRCs occurring annually. From a biomechanical standpoint, the concussion mechanism includes head impact resulting in high magnitude head rotational accelerations. Human studies measuring the accelerations associated with concussive head impacts developed injury risk curves that can be extremely useful from the clinical and safety perspectives. However, recent literature has shown that acceleration magnitudes associated with concussive impacts are extremely variable and not necessarily distinct from the routinely sustained head impact magnitudes. Mounting evidence from human studies has demonstrated that repetitive head impact exposure (HIE) may contribute to decreased SRC tolerance in contact sport athletes. Studies focused on quantifying the relationship between the HIE and incident concussion have been underpowered, as there were limited number of concussions occurring during the observation period. We will utilize the data from the NCAA-DoD Concussion Assessment, Research and Education Consortium (CARE) Head Impact Measurement Core, the largest and most comprehensive study of SRC and repetitive HIE to date, and data from Project Head-to-Head 2 (PHTH2), a large-scale study of SRC and HIE in both collegiate and high school athletes to: (1) determine the association of HIE to SRC occurrence and post-SRC recovery based on the frequency, number, recency, and severity of head impacts sustained in football activities; and (2) build a dynamic predictive algorithm of the SRC risk based on the HIE time series data obtained from the HIT System and other factors, including demographics, concussion history, impact characteristics, and network measures.

项目摘要 运动相关脑震荡 (SRC) 是一个重大的公共卫生问题，导致每年超过 200,000 人次前往 美国急诊室 (ED) 每年发生多达 380 万例 SRC。从 从生物力学的角度来看，脑震荡机制包括头部撞击，导致高强度的头部撞击 旋转加速度。人体研究测量与头部震荡相关的加速度 开发了从临床和安全角度来看非常有用的伤害风险曲线。然而， 最近的文献表明，与震荡影响相关的加速度幅度非常大 可变且不一定与常规持续的头部撞击强度不同。越来越多的证据 人类研究表明，重复性头部撞击暴露 (HIE) 可能会导致 接触运动运动员的 SRC 耐受性。 研究重点是量化 HIE 与突发脑震荡之间的关系 动力不足，因为在观察期间发生的脑震荡次数有限。我们将 利用 NCAA-DoD 脑震荡评估、研究和教育联盟 (CARE) 的数据 头部冲击测量核心，迄今为止最大、最全面的 SRC 和重复 HIE 研究， 以及来自 Project Head-to-Head 2 (PHTH2) 的数据，这是一项针对大学和高中的 SRC 和 HIE 的大规模研究 学校运动员： (1) 根据以下数据确定 HIE 与 SRC 发生和 SRC 后恢复的关联： 足球活动中头部受到撞击的频率、次数、新近程度和严重程度； (2) 建立一个 基于HIT系统获得的HIE时间序列数据的SRC风险动态预测算法 以及其他因素，包括人口统计、脑震荡历史、影响特征和网络测量。