Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical Education

培养转化糖生物学家：糖科学培训与临床教育的结合

基本信息

批准号：
10418674
负责人：
RICHARD D CUMMINGS
金额：
$ 95.85万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

项目摘要

ABSTRACT Currently there are very few individuals that can place clinical medicine within the framework of glycoscience, and vice versa. The key to bridging this translational chasm is to support the development of scientists with requisite interdisciplinary knowledge and experience by providing training in glycosciences concomitantly with education in human biology, altogether framed by an appreciation of human diseases and clinical urgency. This application addresses this need by pioneering a multi-disciplinary career development program in glycosciences within the context of clinical medicine that will create a cadre of “Translational Glycobiologists,” individuals who will perform glycoscience-based inquiry inspired by medical necessity. Fundamentally, this goal will be accomplished by equipping Program Scholars with the requisite intellectual background and the necessary lab skills in the glycosciences, together with an in-depth appreciation of clinical issues. To this end, we will build partnerships between experienced glycoscience researchers and clinicians within the Harvard teaching hospitals to nurture Program Scholar training in glycoscience principles and technical skills integrated with clinical knowledge and practice. The combination of Principal Investigators dedicated to this goal (Drs. Sackstein, Chaikof, and Cummings), together with the assembled faculty and the extraordinary hospital resources, makes this program ideal for career development in Translational Glycobiology. By design, the program capitalizes on the long tradition of translational research within the Brigham & Women’s Hospital, the Beth Israel Deaconess Medical Center, the Massachusetts General Hospital, the Boston Children’s Hospital, and the Dana-Farber Cancer Institute, as well as within the greater Harvard Medical School and Harvard University. Through coursework and seminars, Program Scholars will gain glycoscience knowledge with concomitant development of technical knowledge and skills in both primary laboratory settings and workshops. To ensure development across both scientific and clinical spectrums, each Program Scholar will be jointly mentored by a Research Mentor for lab-based project-oriented glycoscientific training and a Clinical Mentor for hospital-based clinical education. In addition, each Program Scholar will have a dedicated Career Mentor that will further support the Scholar transition towards career independence. Scholar appointments will be for two years (maximum three years), and we anticipate a total of ten Scholars over the duration of the funding period, with four Scholars being junior faculty clinicians and six Scholars being senior post-doctoral fellows. We believe that this unique combination of glycoscience education, laboratory instruction, clinical exposures, and mentoring will launch a cadre of biomedical investigators that will accelerate the growth of glycoscience, and, more importantly, will create needed glycoscience-based breakthroughs that will transform clinical care for disorders of heart, lung, blood, and sleep, and for many, many other diseases.

抽象的目前能够将临床医学置于糖科学框架内的人很少，反之亦然，弥合这一转化鸿沟的关键是支持科学家的发展。通过提供糖科学培训，同时提供必要的跨学科知识和经验人类生物学教育，完全以对人类疾病和临床紧迫性的认识为框架。该应用程序通过在以下领域开创了多学科职业发展计划来满足这一需求临床医学背景下的糖科学将创建一支“转化糖生物学家”骨干队伍从根本上说，受医学必要性启发，将进行基于糖科学的调查的人。通过为项目学者提供必要的知识背景和糖科学方面必要的实验室技能，以及对临床问题的深入了解。最后，我们将在经验丰富的糖科学研究人员和新人之间建立伙伴关系哈佛大学教学医院培养糖科学原理和技术技能方面的项目学者培训与临床知识和实践相结合的主要研究者致力于此。目标（萨克斯坦博士、柴科夫和卡明斯），以及聚集的教师和非凡的医院资源，使该计划成为转化糖生物学职业发展的理想选择。设计中，该项目充分利用了布莱根妇女医院转化研究的悠久传统医院、贝斯以色列女执事医疗中心、马萨诸塞州综合医院、波士顿儿童医院、丹娜法伯癌症研究所以及哈佛医学院通过课程和研讨会，项目学者将获得糖科学。在初级实验室环境中同时发展技术知识和技能的知识为了确保科学和临床领域的发展，每位项目学者将由研究导师共同指导进行基于实验室的项目导向的糖科学培训和此外，每个项目学者都会有一名专门的临床导师。职业导师将进一步支持学者向职业独立过渡。任命期限为两年（最多三年），我们预计在此期间共有十名学者资助期限，其中四名学者为初级教员，六名学者为高级教员我们相信，这种糖科学教育、实验室的独特结合。指导、临床暴露和指导将培养一支生物医学研究人员骨干队伍，他们将加速糖科学的发展，更重要的是，将创造所需的基于糖科学的突破将改变心脏、肺、血液和睡眠疾病的临床护理，并且对许多人来说，许多其他疾病。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The impact of ABO and RhD blood types on Babesia microti infection.

ABO 和 RhD 血型对田鼠巴贝虫感染的影响。

DOI：
发表时间：
2023-01
期刊：
影响因子：
3.8
作者：
Jajosky, Ryan Philip;O'Bryan, Jane;Spichler;Jajosky, Philip G;Krause, Peter J;Tonnetti, Laura
通讯作者：
Tonnetti, Laura

Plasmodium knowlesi (Pk) Malaria: A Review & Proposal of Therapeutically Rational Exchange (T-REX) of Pk-Resistant Red Blood Cells.

诺氏疟原虫 (Pk) 疟疾：回顾

DOI：
发表时间：
2023-10-20
期刊：
影响因子：
0
作者：
Jajosky, Ryan Philip;Wu, Shang;Jajosky, Philip G;Stowell, Sean R
通讯作者：
Stowell, Sean R

O-glycan recognition and function in mice and human cancers.

O-聚糖在小鼠和人类癌症中的识别和功能。

DOI：
10.1042/bcj20180103
发表时间：
2020-04-29
期刊：
The Biochemical journal
影响因子：
0
作者：
G. Cervoni;Jane J. Cheng;K. Stackhouse;Jamie Heimburg;R. Cummings
通讯作者：
R. Cummings

Identification of α1,2-fucosylated signaling and adhesion molecules in head and neck squamous cell carcinoma.

头颈鳞状细胞癌中α1,2-岩藻糖基化信号和粘附分子的鉴定。

DOI：
发表时间：
2022-04-21
期刊：
影响因子：
4.3
作者：
Montesino, Brittany;Steenackers, Agata;Lozano, Juan M;Young, Geoffrey D;Hu, Nan;Sackstein, Robert;Chandler, Kevin Brown
通讯作者：
Chandler, Kevin Brown

Multidimensional separation and analysis of alpha-1-acid glycoprotein N-glycopeptides using high-field asymmetric waveform ion mobility spectrometry (FAIMS) and nano-liquid chromatography tandem mass spectrometry.

使用高场不对称波形离子迁移谱 (FAIMS) 和纳米液相色谱串联质谱法对 α-1-酸性糖蛋白 N-糖肽进行多维分离和分析。