LIMITATIONS TO EXERCISE AFTER PNEUMONECTOMY

肺切除术后运动的限制

• 批准号: 2219481
• 负责人: ROBERT LEE JOHNSON
• 金额: $ 26.55万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2219481
• 关键词: altitude; biological models; cardiac output; dogs; exercise; oxygen consumption; pneumonectomy; pulmonary diffusion; radiotracer; respiratory circulation; respiratory function; respiratory gas transport; respiratory muscles; vascular resistance

DESCRIPTION: (Adapted from Abstract) This is a proposal for a five year renewal of a three year project to examine the extent and mechanisms of exercise limitations after pneumonectomy in dogs. Preliminary data indicate that pneumonectomy is much better tolerated in dogs than in humans and that differences in anatomical distortion of the lung and heart may account for the functional differences between these 2 species. By examining the possible mechanisms whereby the dog can so effectively compensate for the effects of pneumonectomy and the limits of these compensations, further insight may be gained as to how the response might be improved in man. The following specific questions will be addressed in adult foxhounds after extensive lung resections: (1) How does preventing over-expansion affect compensation by the remaining lung? (2) How does a low compliance of the cardiac fossa affect compensation by the heart? (3) How does mediastinal shift affect compensation? and (4) How do morphologic changes correlate with functional compensation? These questions will be addressed in two stages. In stage 1, expansion of the remaining lung and mediastinal shift after right pneumonectomy will be prevented with a silastic balloon, molded to the shape of the right hemithorax and inflated with air or insoluble gas. Volume of air can be adjusted by replacing air in the prosthesis with paraffin or silicone. A control group will undergo right pneumonectomy and balloon implantation without air inflation. In stage 2, limits of compensation will be tested by removing 68 percent of the lungs, either by unbalanced resection (i.e.; right pneumonectomy + left upper lobectomy resulting in mediastinal shift) or by balanced resections leaving equal lung volumes in each hemithorax without mediastinal shift. Comparison of these groups examines the effects of mediastinal shift at a fixed level of expansion in the remaining lung. Compensation will be studied functionally in the awake dog at rest and exercise and morphometrically in the inflation fixed lung after sacrifice.

描述：（改编自摘要）这是一项为期五年的提案 更新一个为期三年的项目，以审查 狗肺切除术后的运动限制。 初步数据 表明狗对肺切除术的耐受性比人类好得多 肺和心脏的解剖扭曲的差异可能 解释这两个物种之间的功能差异。 经过 检查狗可以如此有效地发挥作用的可能机制 补偿全肺切除术的影响及其局限性 补偿，可以进一步了解如何应对 在人身上得到改善。 以下具体问题将在成年猎狐犬中得到解决 广泛的肺切除术：（1）防止过度扩张有何影响 剩下的肺代偿？ （2）合规性低怎么办？ 心窝影响心脏代偿吗？ （三）纵隔如何 变动影响补偿吗？ (4) 形态变化如何关联 具有功能性补偿？ 这些问题将分两期解答 阶段。 在第一阶段，剩余肺扩张和纵隔移位 右肺切除术后，将用模制的硅橡胶球囊进行预防 适合右半胸的形状并用空气或不溶物充气 气体。 可以通过用以下物质替换假肢中的空气来调节空气量 石蜡或硅胶。 对照组将接受右肺切除术 球囊植入无需充气。 在第 2 阶段，限制为 将通过切除 68% 的肺部来测试补偿，或者通过 不平衡切除（即右肺切除+左上肺叶切除） 导致纵隔移位）或通过平衡切除留下相等的 每个半胸的肺容量，无纵隔移位。 比较 这些小组研究了纵隔移位在固定水平下的影响 剩余肺的扩张。 补偿将进行功能性研究 醒着的狗在休息和运动时以及在充气时的形态测量 处死后固定肺。