NEURAL ASSEMBLIES--SOMATIC MAP EXPERIMENTS AND MODELS

神经组装——体细胞图实验和模型

• 批准号: 2247038
• 负责人: GEORGE L GERSTEIN
• 金额: $ 19.67万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2247038
• 关键词: action potentials; afferent nerve; brain electrical activity; brain mapping; computer simulation; electrostimulus; laboratory rat; microelectrodes; model; neural information processing; neural plasticity; somesthetic sensory cortex

We propose to study cortical organization and reorganization at the level of neuronal networks and assemblies, using both experimental and theoretical methods. The experimental vehicle will be rat somatosensory cortex subjected to local electrical stimulation; this forces rapid changes in somatic map boundaries. During such changes we propose to make extracellular region. These measurements and their subsequent interpretation in terms of neuronal assembly processes will rest on recording technologies and analytic mathematics that have largely been developed by our laboratory over the last decade. The proposed theoretical work will examine computer simulations of neuronal networks arranged to reproduce the changes in map magnification and boundaries which underlie the experimental work. As information about "effective connectivity" and neuronal assembly properties emerges from the experiments, these new constraints will be incorporated into the ongoing modeling. The models will analysis techniques, and are likely to suggest additional experimental measurements. The overall project should give considerable insight into actual and possible mechanisms for cortical modularity and reorganization; we will here have, for the first time, direct experimental access to the details of the process by which the brain reallocates its computational resources.

我们建议在该水平上研究皮质组织和重组 神经元网络和组件，都使用实验和 理论方法。 实验工具将是大鼠体感 皮质受到局部电刺激；这迫使快速变化 在躯体地图边界中。 在此类更改期间，我们建议 细胞外区域。 这些测量及其随后的 根据神经元组装过程的解释将基于 录制技术和分析数学主要是 在过去十年中，我们的实验室开发。 提出的理论 工作将检查安排的神经元网络的计算机模拟 复制构图的地图放大和边界的变化 实验工作。 作为“有效连通性”的信息， 神经元组装属性来自实验，这些新的 约束将纳入正在进行的建模中。 模型 将分析技术，并可能提出其他实验 测量。 整个项目应该对 皮质模块化和重组的实际和可能的机制； 我们将首次在这里直接实验到 大脑重新关注其计算的过程的详细信息 资源。