Center for Clinical and Translational Research

临床和转化研究中心

• 批准号: 10409659
• 负责人: FREDERICK Gerard MOELLER
• 金额: $ 370.39万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-08 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10409659
• 关键词: Advisory Committees; Area; Basic Science; Biomedical Research; Biometry; Caregivers; Caring; Clinical; Clinical Research; Collaborations; Communities; Development; Diagnostic; Disease; Doctor of Medicine; Educational Models; Endowment; Environment; Fostering; Funding; Gifts; Goals; Health Care Research; Health Sciences; Health system; Informatics; Institute of Medicine (U.S.); Institution; Institutional support resources; Longevity; Methods; Mining; National Center for Advancing Translational Sciences; Patients; Performance; Phase; Pilot Projects; Process; Provider; Reporting; Research; Research Design; Research Infrastructure; Research Methodology; Resources; Role; Science; Scientist; Source; Special Population; Speed; System; Therapeutic; Training; Translating; Translational Research; Translations; United States; Universities; Virginia; Workforce Development; base; biomedical informatics; clinical center; clinical practice; community engagement; data warehouse; doctoral student; experience; human subject protection; improved; informatics tool; innovation; insight; large datasets; medical schools; multiple data types; next generation; operation; patient population; preventive intervention; programs; recruit; senior faculty

Contact PD/PI: MOELLER, FREDERICK Gerard The Center for Clinical and Translational Research (CCTR) at Virginia Commonwealth University (VCU) promotes clinical and translational research (CTR), moving research advances from basic science into clinical practice, and improving the quality and efficiency of clinical research. Over the last 5 years the CCTR has become a critical component of VCU’s clinical and translational research environment. The value placed on the CCTR’s role in advancing clinical research is evidenced by over $43,000,000 of institutional support, including a recent $16 million gift to rename the CCTR the C. Kenneth and Dianne Wright Center for Clinical and Translational Research. In addition, the CCTR serves as the only CTSA funded hub in Virginia, fostering statewide and national collaborations in clinical and translational research in areas of human subjects protection and recruitment, community engagement, team science, informatics, and scientific review. The overall CCTR strategic goal is to catalyze CTR through programs and processes that enhance quality and efficiency, integrate research and clinical practice, and provide training to develop the CTR workforce. This goal will be achieved in collaboration with the CTSA Network and implemented at VCU and our partner institutions locally, regionally, and nationally, as described in detail related to each overall aim below. An important theme across cores is innovation in methods for processing, analysis, mining, integrating, and sharing of large data sets. Overall Aim 1: Promote translational research workforce development with experience based training in informatics, team science, biostatistics, research design, and regulatory science, sharing and collaborating with the CTSA Network in best educational practices to develop the next generation of CTR scientists. Overall Aim 2: Mobilize existing strengths in community engagement and team science to engage stakeholder communities at every translational phase to become research partners and form collaborative clinical translational science teams. Overall Aim 3: Integrate all phases of CTR across the lifespan and in special populations by increasing hub and network research capacity and connecting with relevant providers, patients, caregivers, and other stakeholders to guide research, care, and recruitment. Overall Aim 4: Advance clinical and translational research methods and processes to speed translation, build collaborations, and optimize resources within VCU and with the CTSA Network. Overall Aim 5: Implement informatics systems to integrate multiple types of data to gain insight into diseases and mechanisms, to enhance training, to collect metrics to improve performance and gauge impact, and to bridge research to clinical practice across the CCTR and the CTSA Network. Project Summary/Abstract Page 227 Contact PD/PI: MOELLER, FREDERICK Gerard As described in the Institute of Medicine (IOM) report on the CTSA program, although there has been an exponential increase in biomedical research in the United States in the last 50 years, translating the findings from basic and clinical research to clinical practice has fallen short. For the next 5 years of funding, the CCTR proposes to capitalize on strengths in a special patient population, community engagement, workforce development, and informatics, to expand connections with the CTSA network to promote innovation in methods, processes, and training, focused on the delivery of high quality clinical and translational research. In addition, utilizing biomedical informatics tools, the CCTR will promote a greater integration of healthcare and research within VCU and across statewide and national partners.

联系人 PD/PI：MOELLER、FREDERICK Gerard 弗吉尼亚联邦大学 (VCU) 临床与转化研究中心 (CCTR) 促进临床和转化研究（CTR），研究进展从基础科学到 临床实践，并提高临床研究的质量和效率 在过去的 5 年里。 CCTR 已成为 VCU 临床和转化研究环境的重要组成部分。 超过 43,000,000 美元的机构资金证明了 CCTR 在推进临床研究方面的作用 支持，包括最近捐赠 1600 万美元，将 CCTR 更名为 C. 肯尼思和黛安·赖特中心 (C. Kenneth and Dianne Wright Center) 此外，CCTR 是弗吉尼亚州唯一由 CTSA 资助的中心。 促进人类受试者领域临床和转化研究方面的司法和国家合作 保护和招募、社区参与、团队科学、信息学和科学审查。 CCTR 的总体战略目标是通过提高 CTR 的计划和流程来促进 CTR 质量和效率，整合研究和临床实践，并提供培训以开发 CTR 这一目标将与 CTSA 网络合作实现，并在 VCU 和我们的员工队伍中实施。 地方、区域和国家的伙伴机构，如下面与每个总体目标相关的详细描述。 跨核心的一个重要主题是处理、分析、挖掘、集成和分析方法的创新。 共享大数据集。 总体目标 1：以经验为基础促进转化研究队伍的发展 信息学、团队科学、生物统计学、研究设计和监管科学方面的培训、分享 并与 CTSA Network 合作开展最佳教育实践，以培养下一代 CTR 科学家。 总体目标 2：调动社区参与和团队科学方面的现有优势， 在每个转化阶段让利益相关者社区参与进来，成为研究合作伙伴并形成 协作临床转化科学团队。 总体目标 3：整合整个生命周期和特殊人群的 CTR 的所有阶段 提高中心和网络研究能力，并与相关提供者、患者、 护理人员和其他利益相关者指导研究、护理和招募。 总体目标 4：推进临床和转化研究方法和流程，加快速度 翻译、建立合作并优化 VCU 内和 CTSA 网络的资源。 总体目标 5：实施信息学系统以集成多种类型的数据以获得洞察力 深入了解疾病和机制，加强培训，收集指标以提高绩效和 衡量影响，并将研究与 CCTR 和 CTSA 网络的临床实践联系起来。 项目总结/摘要第 227 页 联系人 PD/PI：MOELLER、FREDERICK Gerard 正如医学研究所 (IOM) 关于 CTSA 计划的报告所述，尽管 过去 50 年来，美国生物医学研究呈指数级增长，转化为研究结果 从基础、临床研究到临床实践，CCTR未来5年的经费都不足。 建议利用特殊患者群体、社区参与、劳动力的优势 发展和信息学，扩大与 CTSA 网络的联系，促进创新 方法、流程和培训，专注于提供高质量的临床和转化研究。 此外，利用生物医学信息学工具，CCTR 将促进医疗保健和医疗保健的更大程度融合。 弗吉尼亚联邦大学内部以及全州和国家合作伙伴的研究。

项目成果

Consequences of chronic frequent premature atrial contractions: Association with cardiac arrhythmias and cardiac structural changes.

慢性频繁房性早搏的后果：与心律失常和心脏结构变化的关联。

• 发表时间: 2019
• 影响因子: 2.7
• 作者: Gunda, Sampath;Akyeampong, Daniel;Gomez;Jovin, Daniel G;Kowlgi, Narayan G;Kaszala, Karoly;Tan, Alex Y;Koneru, Jayanthi N;Kron, Jordana;Ellenbogen, Kenneth A;Huizar, Jose F
• 通讯作者: Huizar, Jose F

Resolution of new left bundle branch block and ventricular tachycardia with immunosuppressive therapy in a patient with cardiac sarcoidosis.

心脏结节病患者通过免疫抑制治疗解决新发左束支传导阻滞和室性心动过速。

• 发表时间: 2019-07
• 作者: Garg, Aatish;Syed, Huzaefah;Padala, Santosh K;Ellenbogen, Kenneth A;Kron, Jordana
• 通讯作者: Kron, Jordana

Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients With Baseline Cirrhosis or High FIB-4 Scores.

对于基线肝硬化或高 FIB-4 评分的患者，在 HCV 根除后 10 年内，肝细胞癌的风险持续增加。

• 发表时间: 2019
• 影响因子: 29.4
• 作者: Ioannou, George N;Beste, Lauren A;Green, Pamela K;Singal, Amit G;Tapper, Elliot B;Waljee, Akbar K;Sterling, Richard K;Feld, Jordan J;Kaplan, David E;Taddei, Tamar H;Berry, Kristin
• 通讯作者: Berry, Kristin

Uncertainty in Decision Making in Medicine: A Scoping Review and Thematic Analysis of Conceptual Models.

医学决策的不确定性：概念模型的范围界定审查和主题分析。

• 发表时间: 2020
• 作者: Helou, Marieka A;DiazGranados, Deborah;Ryan, Michael S;Cyrus, John W
• 通讯作者: Cyrus, John W

Effects of Moving the United States Medical Licensing Examination Step 1 After Core Clerkships on Step 2 Clinical Knowledge Performance.

将美国医疗执照考试第 1 步移至核心实习岗位之后对第 2 步临床知识表现的影响。

• 发表时间: 2020
• 作者: Jurich, Daniel;Santen, Sally A;Paniagua, Miguel;Fleming, Amy;Harnik, Victoria;Pock, Arnyce;Swan;Barone, Michael A;Daniel, Michelle
• 通讯作者: Daniel, Michelle