DOPAMINERGIC INNERVATION OF THE SUBTHALAMIC NUCLEUS

丘脑底核的多巴胺能神经支配

• 批准号: 2242765
• 负责人: KELLY A ALLERS
• 金额: $ 1.3万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2242765
• 关键词: DOPAMINERGIC; INNERVATION; SUBTHALAMIC; NUCLEUS

Dopamine (DA) innervation of the afferent basal ganglia, the caudate and putamen, is well established and essential to selected motor and cognitive processes(1). By contrast, the existence and function of DA pathways to the subthalamic nucleus (STN) and other key efferent nuclei of the basal ganglia are still obscure. Nonetheless, recent investigations suggest this innervation is histochemically dense, and by its location, strategically situated to potentially modulate striatal outflow(9,14,26) . As a first step in elucidating the role of DA innervation of striatal outflow, we will study the anatomy, biochemistry and behavioral pharmacology of the DA projections to STN in the rat, a nucleus known to play a key role in modulation of normal and abnormal motor function in rodents and mammals (14,28).

传入基底神经节，尾状和 putamen，对选定的电动机和 认知过程（1）。相比之下，DA的存在和功能 丘脑下核（STN）和其他钥匙传出核的途径 基底神经节仍然晦涩。尽管如此，最近 调查表明，这种神经在组织化学上是密集的，并且 它的位置，策略性地位于潜在的调节纹状体 流出（9,14,26）。作为阐明DA的作用的第一步 纹状体流出的神经，我们将研究解剖学，生化 DA投影的行为药理学对大鼠的stn的投影 已知的核在调制正常和异常中起关键作用 啮齿动物和哺乳动物的运动功能（14,28）。