PREDICTING FAILURE OF HUMAN PROXIMAL FEMURS

预测人类近端股骨的失效

• 批准号: 2078181
• 负责人: Z MARIA ODEN
• 金额: $ 2.37万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-31 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2078181
• 关键词: PREDICTING; FAILURE; HUMAN; PROXIMAL; FEMURS

The prevention of hip fracture is an important public health issue. This common injury has a profound economic and social impact on the health care system. To better understand the factors that influence femoral fracture and to be able to predict the loads required to fracture a femur, a combination of experimental and computational techniques will be employed. While computational methods could be employed to study those aspects of hip fracture etiology that relate to bone strength, global fracture prediction with the finite element method has received only limited attention, primarily because of the lack of verified failure theories to use in computational models. In particular, since local failure of trabecular bone is a key factor in global fracture processes and suitable, multi-axial failure theories for trabecular bone are not available, developing a validated model for trabecular bone failure would be a significant step toward the use of computational methods to predict fracture in the human skeleton. This project is designed to determine an appropriate failure criterion for trabecular bone and use that criterion to predict the failure load of trabecular bone under various loading environments. We will comprehensively evaluate several failure criteria and finite element modeling assumptions for predicting of bone failure starting with simple geometries and loads and progressing toward more complex shapes and loads. The testing will begin with cylindrical cores of trabecular bone under uniaxial loading and continue to the level of full human proximal femurs loaded to failure in a falling configuration. The knowledge gained in this study will improve the understanding of hip fracture etiology and allow further research toward isolating the factors which influence hip fracture risk.

预防髋部骨折是一个重要的公共卫生问题。这 常见伤害对健康具有深远的经济和社会影响 护理系统。为了更好地了解影响股骨的因素 断裂并能够预测断裂所需的载荷 股骨，实验和计算技术的结合将 被雇用。虽然可以采用计算方法来研究这些 与骨强度相关的髋部骨折病因学方面，全球 有限元法断裂预测仅获得 关注有限，主要是因为缺乏经过验证的故障 用于计算模型的理论。特别是由于当地 骨小梁失效是整体骨折过程的关键因素 并没有适用于骨小梁的多轴失效理论 可用，开发一个经过验证的骨小梁衰竭模型将 是朝着使用计算方法进行预测迈出的重要一步 人体骨骼骨折。该项目旨在确定 骨小梁的适当失效标准并使用该标准 预测不同载荷下骨小梁的破坏载荷 环境。我们将综合评估多项失败标准 以及用于预测骨衰竭的有限元建模假设 从简单的几何形状和负载开始，逐步发展到更多 复杂的形状和载荷。测试将从圆柱形芯开始 骨小梁在单轴载荷下的水平并继续到 完整的人类近端股骨在坠落配置中加载至失效。 本研究中获得的知识将提高对髋关节的理解 骨折病因学并允许进一步研究隔离因素 这会影响髋部骨折的风险。