Community Developed Technology-Based Messaging to Increase SARS-CoV-2 Vaccine Uptake Among People Who Inject Drugs

社区开发了基于技术的消息传递，以增加注射毒品者对 SARS-CoV-2 疫苗的使用

• 批准号: 10408870
• 负责人: Ian David Aronson
• 金额: $ 66.16万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408870
• 关键词: 2019-nCoV; Address; African American; Age; Area; COVID-19; COVID-19 complications; COVID-19 impact; COVID-19 mortality; COVID-19 vaccination; COVID-19 vaccine; Car Phone; Charge; Client; Clinical Trials; Collaborations; Communities; Consult; Criminal Justice; Crowding; Data; Death Rate; Dose; Drops; Enrollment; Ensure; Ethnic Origin; Face; Feedback; Fright; Gender; HIV/HCV; HIV/TB; Handwashing; Harm Reduction; Hepatitis A; Hepatitis B Vaccination; Homelessness; Individual; Influenza vaccination; Injecting drug user; Intervention; Interview; Language; Latino; Latino Population; Link; Location; Medical; Methods; New York; New York City; Outcome; Outcome Measure; Participant; Persons; Pharmaceutical Preparations; Phase; Plant Roots; Population; Race; Randomized; Randomized Clinical Trials; Research; Respondent; Risk; SARS-CoV-2 infection; Sampling; Seeds; Series; Shelter facility; Site; Social Distance; Structure; Substance Use Disorder; Tablet Computer; Tablets; Target Populations; Technology; Testing; Text; Text Messaging; Time; Trust; United States; Vaccinated; Vaccination; Vaccines; Virus; Water; Work; base; coronavirus disease; cost; design; ethnic minority; experience; follow-up; group intervention; health care availability; health disparity; infection risk; maltreatment; overdose prevention; peer; primary outcome; racial minority; recruit; response; secondary outcome; social stigma; substance use; treatment duration; treatment group; unvaccinated; uptake; vaccine acceptance; vaccine access; vaccine hesitancy

Project Summary/Abstract People who inject drugs (PWID) experience disproportionate risk of being infected with SARS-CoV-2, the virus that causes COVID-19. Unfortunately, due to stigma, fear of mistreatment, and other factors, PWID are far less likely to be vaccinated compared to other populations. African American and Latino populations also face disproportionate risk of infection and far greater COVID-19 death rates compared to White populations, yet due to issues including longstanding medical mistrust are also far less likely to vaccinate. For African American and Latino PWID, COVID-related risks increase even further and vaccination becomes even more unlikely. In response, we propose to continue our collaboration with New York Harm Reduction Educators (NYHRE) a prominent New York City community based organization serving African American and Latino PWID. To increase SARS-CoV-2 vaccination among our target population, we will first assemble a community advisory board (CAB) that we will consult at all phases of the project, then conduct a series of qualitative interviews (n=20) to better understand barriers to testing and vaccination among PWID, and how we can potentially address these via technology-based messaging. We will then work with our CAB and additional PWID participants (n=30) to iteratively develop, evaluate, and refine intervention video and text message content in English and Spanish. Next, we will recruit a separate sample of PWID (n=500) via respondent driven sampling to evaluate these newly created intervention materials as part of a clinical trial. Upon enrollment, participants will be offered a free vaccination against SARS-CoV-2. To increase the rigor of our trial, we will only provide our intervention materials to participants who do not accept vaccination when offered (based on current rates of PWID vaccination against influenza we expect the overwhelming majority will decline). Those who do not initially vaccinate will be randomized into one of two intervention groups: a no video group, and a video text group. The no video group will receive weekly text messages designed to address barriers to vaccination identified in formative research. The video text group will receive the same texts, along with links to videos we develop with NYHRE staff and clients to address barriers to SARS-CoV-2 vaccination. Our intervention will track response rates in both groups. Primary outcome measures will be vaccination within the initial weeks following enrollment and the subsequent intervention period by treatment group. Additional outcomes will include vaccination rates by demographic, including race/ethnicity and primary language (i.e. do English speaking participants respond differently to specific intervention components compared to monolingual Spanish speakers). If shown successful this approach can be replicated with additional populations that experience health disparities, and in different languages across the United States.

项目概要/摘要 注射吸毒者 (PWID) 感染 SARS-CoV-2 的风险不成比例， 引起 COVID-19 的病毒。不幸的是，由于耻辱、对虐待的恐惧以及其他因素，吸毒者 与其他人群相比，接种疫苗的可能性要小得多。非裔美国人和拉丁裔人口也 与白人相比，他们面临着不成比例的感染风险和更高的 COVID-19 死亡率，但 由于长期的医疗不信任等问题，接种疫苗的可能性也大大降低。对于非裔美国人 和拉丁裔吸毒者，与新冠病毒相关的风险进一步增加，疫苗接种的可能性也变得更加不可能。 作为回应，我们建议继续与纽约减害教育工作者合作 (NYHRE) 是纽约市著名的社区组织，为非裔美国人和拉丁裔注射吸毒者提供服务。 为了增加目标人群中的 SARS-CoV-2 疫苗接种，我们将首先制定社区建议 我们将在项目的各个阶段咨询董事会（CAB），然后进行一系列定性访谈（n=20） 更好地了解吸毒者检测和疫苗接种的障碍，以及我们如何解决这些问题 通过基于技术的消息传递。然后，我们将与 CAB 和其他 PWID 参与者 (n=30) 合作， 迭代开发、评估和完善英语和西班牙语的干预视频和短信内容。 接下来，我们将通过受访者驱动抽样招募一个单独的注射吸毒者样本（n = 500）来评估 这些新创建的干预材料是临床试验的一部分。报名后，参与者将获得 免费接种 SARS-CoV-2 疫苗。为了提高试验的严格性，我们只会提供干预 向不接受疫苗接种的参与者提供的材料（根据当前注射吸毒者疫苗接种率 针对流感，我们预计绝大多数人都会下降）。那些最初没有接种疫苗的人将被 随机分为两个干预组之一：无视频组和视频文本组。无视频组 将每周收到旨在解决形成性研究中发现的疫苗接种障碍的短信。 视频文本组将收到相同的文本，以及我们与 NYHRE 工作人员一起开发的视频链接， 客户解决 SARS-CoV-2 疫苗接种障碍。我们的干预措施将跟踪两组的反应率。 主要结果指标将是入组后最初几周内的疫苗接种以及随后的疫苗接种 治疗组的干预期。其他结果将包括按人口统计的疫苗接种率， 包括种族/民族和主要语言（即说英语的参与者对特定的反应是否不同） 与单语西班牙语使用者相比的干预成分）。 如果成功的话，这种方法可以在其他健康人群中复制 差异，并且在美国各地使用不同的语言。