ECHO Supplement

回声补充

基本信息

批准号：
10412797
负责人：
Susan L Schantz
金额：
$ 33.34万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10412797
关键词：
Address Attention Benzophenones Biological Markers Birth Birth Weight California Chemical Exposure Chemicals Child Health Chronic Chronic stress Complex Corticotropin-Releasing Hormone Data Data Analyses Data Collection Data Set Development Endocrine Disruptors Environmental Policy Etiology Exposure to Geography Gestational Age Green space Household Illinois Intervention Length Leukocytes Measurement Measures Mediating Methodology Mothers Neighborhoods Outcome Parabens Phenols Plasma Poly-fluoroalkyl substances Pregnancy Pregnant Women Production Protocols documentation Psychosocial Stress Research San Francisco Shapes Short-Term Memory Social Perception Social Policies Social status Socioeconomic Status Source Stress Triclosan Umbilical cord structure Universities adverse birth outcomes base biological adaptation to stress built environment cognitive development cognitive function cohort data harmonization data management early childhood ethnic diversity experience indexing infancy information processing innovation maternal stress neurodevelopment offspring prenatal prenatal exposure prenatal stress professional atmosphere racial diversity recruit resilience social cognition social stress social stressor socioeconomics stress resilience telomere triclocarban

项目摘要

Project Summary We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal psychosocial stress on birth outcomes and early neurodevelopment. We will focus on two groups of high production volume endocrine disrupting chemicals (EDCs) regularly detected in pregnant women, which research suggests may impact development, but for which data on child health outcomes is sparse: phenols (bisphenols, benzophenone, dichlorophenols, parabens, triclosan, triclocarban) and perfluorinated alkyl substances (PFAS). We will measure three indices of chronic stress and resilience: 1) Perceptual – perceptions of social standing and stress exposures in household, neighborhood, and work environments; 2) Place-based – neighborhood level socioeconomic status, civic engagement, green space and built environment; and 3) Biomarkers - telomere length in maternal and umbilical cord leukocytes and corticotropin releasing hormone (CRH) levels in maternal plasma. We will measure birth outcomes (birth weight and gestational age) and we will use innovative approaches to assess basic cognitive functions including working memory, attention, information processing, and social cognition in infancy and early childhood. We will address three specific aims: (1) Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth outcomes and cognitive development of offspring. (2) Evaluate the relationship between measures of prenatal stress and measures of adverse birth outcomes and cognitive development of offspring. Importantly, for this aim we will also assess whether biomarkers of stress response mediate the relationship between perceptual and place-based stress and developmental outcomes. (3) Evaluate whether maternal stress modifies observed relationships between EDC exposures and measures of adverse birth outcomes or cognitive development of offspring. During the planning period, we will harmonize data collection and management (including biospecimens, stress measurements, and measurements of birth outcomes and cognitive functions) across our two cohorts to prepare for merging our two data sets and for sharing our data with the ECHO Data Analysis Center. During UG3 stage we will also actively participate in development and implementation of the ECHO-wide study protocol contributing expertise and methodology for assessing maternal stress, offspring cognitive development and our experiences integrating and harmonizing data collection across our two geographically distinct pregnancy cohorts. In summary, our innovative research approach will contribute to ECHO by providing a framework for integrating cumulative chemical exposures with chronic psychosocial stress and sources of resilience in order to understand the complex set of prenatal etiologic factors that shape developmental outcomes in infancy and early childhood.

项目概要我们建议整合伊利诺伊大学和伊利诺伊大学目前正在招募的两个怀孕队列加州大学旧金山分校 (UCSF) 旨在形成一个在地理、社会经济、种族和种族多样化队列（ECHO.CA.IL）研究化学品暴露和孕产妇的累积影响我们将重点关注两组高出生结局和早期神经发育的社会心理压力。孕妇中定期检测到的内分泌干扰化学物质（EDC）的产量，研究表明可能会影响发育，但有关儿童健康结果的数据很少：苯酚（双酚、二苯甲酮、二氯酚、对羟基苯甲酸酯、三氯生、三氯卡班）和全氟烷基我们将衡量慢性压力和复原力的三个指标：1) 感知 – 看法。家庭、邻里和工作环境中的社会地位和压力暴露；2) 基于地点的 – 社区层面的社会经济地位、公民参与、绿色空间和建筑环境；3) 生物标志物 - 母体和脐带白细胞的端粒长度以及促肾上腺皮质激素释放激素我们将测量母体血浆中的 CRH（CRH）水平。使用创新方法评估基本认知功能，包括工作记忆、注意力、信息我们将解决三个具体目标：（1）评估产前 EDC 暴露与不良出生结局指标之间的关系 (2) 评估产前测量之间的关系重要的是，对于后代的不良出生结果和认知发展的压力和测量。为了这个目的，我们还将评估压力反应的生物标志物是否介导知觉之间的关系。 (3) 评估母亲压力是否会改变观察到的 EDC 暴露与不良出生结果或认知测量之间的关系在规划期间，我们将统一数据收集和管理。（包括生物样本、压力测量以及出生结果和认知功能的测量）跨我们的两个队列，准备合并我们的两个数据集并与 ECHO 数据共享我们的数据在UG3阶段我们还将积极参与分析中心的开发和实施。 ECHO范围内的研究协议为评估孕产妇压力、后代提供专业知识和方法认知发展以及我们在两个领域整合和协调数据收集的经验总之，我们的创新研究方法将有助于 ECHO 提供了一个将累积化学品暴露与慢性社会心理压力相结合的框架和复原力的来源，以了解塑造的一系列复杂的产前病因婴儿期和幼儿期的发育结果。