Improving the usage and impact of the Integrated Aging Studies Databank and Registry

改善综合老龄化研究数据库和登记处的使用和影响

基本信息

批准号：
10408207
负责人：
DALANE W KITZMAN
金额：
$ 23.23万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10408207
关键词：
Address Adopted Aging American Applications Grants Area Biological Specimen Banks Capsicum Certification Characteristics Collaborations Communities Data Data Set Development Elderly FAIR principles Fostering Frequencies Funding Future Generations Geography Gerontology Goals Hand Infrastructure Journals Licensing Link Measures Medical Metadata Modernization Paper Physical Function Pilot Projects Play Postdoctoral Fellow Process Publications Publishing Quality Control Registries Research Research Personnel Resource Sharing Resources Role Sample Size Sampling Science Scientist Statistical Methods Structure TRUST principles Testing Text Trust United States National Institutes of Health Update Visual career computer center cost data access data repository data sharing design early-career faculty experience forest improved innovation interest interoperability machine learning method multiple datasets repository statistics study characteristics synergism tool usability

项目摘要

Project Summary The Integrated Aging Studies Databank and Registry (IASDR) is a repository designed for sharing data across the NIH-funded national network of Older Americans Independence Centers (OAICs). The IASDR hosted and maintained by the OAIC’s Coordinating Center (CC). As a domain-specific repository, the existing IASDR contains multiple data sets generated from aging studies conducted at the Wake Forest OAIC (WF-OAIC), as well as a biospecimen bank for samples collected from some of the included studies. The IASDR thus serves as a valuable resource for the aging research community, especially for early career faculty. The data repository befits early career investigators who want to conduct small pilot studies for testing out conjectures and research hypotheses, and to efficiently produce useful information such as preliminary effect sizes for grant applications or to power future studies. Gaps were identified when the IASDR was evaluated against modern repository requirements. The IASDR was first started more than a decade ago, and the development process did not necessarily strictly adhere to contemporary biomedical-data repository principles such as the FAIR and TRUST principles. Importantly, barriers are present for users in accessing key information for decision support. For example, currently summary statistics such as mean, standard deviation, frequency for variables and association information between variables, which are often critical in helping users to decide whether or not to pursue actual data, are not present in the IASDR metadata. The lack of such preliminary information could deter interested users from using the repository. To address gaps and limitations of the IASDR as related to its “FAIR”-ness and “TRUST”- worthiness, this proposal contains two specific aims: (1) Enhance the metadata layer by providing users with key analytic information such as mean, frequency, and association between variables, and (2) improve the IASDR along the FAIR and TRUST principles and seek certification.

项目概要综合老龄化研究数据库和登记处 (IASDR) 是一个专为以下目的而设计的存储库：在 NIH 资助的美国老年人独立全国网络中共享数据中心 (OAIC)。IASDR 由 OAIC 协调中心 (CC) 托管和维护。作为特定于域的存储库，现有的 IASDR 包含从以下位置生成的多个数据集：在维克森林大学 OAIC (WF-OAIC) 以及生物样本库进行的老化研究因此，对于从某些纳入的研究中收集的样本来说，IASDR 是有价值的。老龄化研究界的资源，特别是早期职业教师的数据。存储库适合想要进行小型试点研究以进行测试的早期职业研究人员猜想和研究假设，并有效地产生有用的信息，例如确定了资助申请或支持未来研究的初步效应大小。当 IASDR 根据现代存储库要求进行评估时 IASDR 是第一个。十多年前就开始了，开发过程并不一定严格遵守当代生物医学数据存储库原则，例如公平和信任重要的是，用户在获取决策关键信息时存在障碍。例如，当前汇总统计数据，例如均值、标准差、频率。变量和变量之间的关联信息，这通常对于帮助用户决定是否追求实际数据的决定不存在于 IASDR 元数据中。缺乏此类初步信息可能会阻止感兴趣的用户使用该存储库。为了解决 IASDR 与其“公平”和“信任”相关的差距和局限性 - 值得一提的是，该提案包含两个具体目标：（1）通过以下方式增强元数据层：为用户提供关键分析信息，例如平均值、频率和关联性 (2) 按照公平和信任原则改进 IASDR，并寻求认证。