Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center

MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心

基本信息

批准号：
10406627
负责人：
TODD T BROWN
金额：
$ 6.2万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10406627
关键词：
Achievement Acquired Immunodeficiency Syndrome Aging Award Baltimore Biological Specimen Banks Cardiovascular system Caring Chicago Chronic Disease Cohort Studies Cryopreservation Data Data Coordinating Center Disease District of Columbia Echocardiography Enrollment Epidemic Equilibrium Follow-Up Studies Funding Goals HIV HIV Infections Health Inflammation Laboratories Los Angeles Lung Malignant Neoplasms Measurement Natural History Neurocognitive Parents Pathogenesis Peripheral Blood Mononuclear Cell Physical activity Plasma Play Protocols documentation Questionnaires Reading Recording of previous events Research Role Site Sleep Specimen T-Lymphocyte Subsets The Multicenter AIDS Cohort Study Viral load measurement Washington Woman Women&apos s Interagency HIV Study antiretroviral therapy career development clinical research site cohort comorbidity follow-up health disparity improved men men who have sex with men psychosocial recruit repository research study response

项目摘要

Project Summary of Funded Parent Award This application is for the renewal of the Study to Help the AIDS Research Effort (SHARE), which has been the Baltimore-Washington DC site of the Multicenter AIDS Cohort Study (MACS) since 1984. The MACS was established with sites in Baltimore-Washington, Chicago, Pittsburgh, and Los Angeles, initially to study the natural history of HIV infection in men who have sex with men and later, with the advent of effective combination antiretroviral therapy (cART), the treated history of HIV infection, including the relationship between long-term controlled HIV infection and chronic diseases and co-morbidities associated with aging. To reflect these changing priorities in HIV research, SHARE has had subsequent enrollments to balance proportions of HIV- and HIV+ men and to reflect the HIV epidemic more accurately. Men enrolled have been followed semi annually since 1984 or enrollment and have a) provided questionnaire data, physical exam data, laboratory data (including HIV serostatus, T cell subset measurements, and HIV viral load measurements), and a large repository of plasma, serum, cryopreserved peripheral blood mononuclear cells, and other specimens; and these have permitted SHARE and MACS to make major contributions to the understanding of treated and untreated HIV disease, and comorbidities associated with increased survival due to antiretroviral treatment. The present application, in response to RFA-HL-19-008, aims to extend followup of the SHARE cohort (about 640 men) from 2019 to 2026, to allow merger of SHARE (and the other MACS sites) with the nine sites of the Women’s Interagency HIV Study (WIHS) into a single cohort, termed the MACS-WIHS Combined Cohort Study (CCS), that will include both men and women. The specific aims of the CCS are outlined in a parallel application from the putative Data and Coordinating Center (DACC) of the CCS, and the 10 Specific Aims of that single cohort are outlined in the DACC application for the CCS; these include Cardiovascular (CV), Pulmonary/Sleep (PS), Neurocognitive NC), Aging (AG), Cancer, HIV Pathogenesis (PA), Psychosocial (PS), Health Disparities, Platform (PL), and Career Development (CD) Aims. The specific aims of the SHARE Clinical Research Site (CRS) are to: 1) play a leading role in the achievement 7 of these Aims by the CCS (i.e., CV, PS, AG, PA, PS, PL, and CD), including serving as a reading center for echocardiography and sleep studies; 2) to contribute to the achievement of the other 3 CCS aims, and 3) to implement all applicable CCS protocols and support the scientific goals of the CCS. Local initiatives on inflammation and physical activity will also support these aims, which take full advantage of the extensive follow-up and repository of biological specimens already available from this cohort and which will be extended under this proposal, enabling further contributions to our understanding and care of comorbidities and other health issues faced by people living with HIV today.

资助家长奖项目概要本申请旨在更新帮助艾滋病研究工作 (SHARE) 的研究，该研究已自 1984 年以来一直是多中心艾滋病队列研究 (MACS) 的巴尔的摩-华盛顿特区站点。MACS 成立了巴尔的摩-华盛顿、芝加哥、匹兹堡和洛杉矶的研究中心，最初是为了研究随着有效组合药物的出现，男男性接触者及后来的艾滋病毒感染自然史抗逆转录病毒治疗（cART），治疗的HIV感染史，包括长期治疗与HIV感染之间的关系控制艾滋病毒感染以及与衰老相关的慢性疾病和并发症。改变艾滋病毒研究的重点，SHARE随后进行了招募，以平衡艾滋病毒和艾滋病毒的比例艾滋病毒阳性男性，为了更准确地反映艾滋病毒流行情况，每半年对登记的男性进行一次随访。自1984年起或入学并有 a) 提供问卷数据、体检数据、实验室数据（包括 HIV 血清状态、T 细胞亚群测量和 HIV 病毒载量测量）以及大型存储库血浆、血清、冷冻保存的外周血单核细胞和其他标本；允许 SHARE 和 MACS 为了解已治疗和未治疗的艾滋病毒做出重大贡献疾病以及与抗逆转录病毒治疗提高生存率相关的合并症。本申请响应 RFA-HL-19-008，旨在延长 SHARE 队列的随访（约 640 人）从 2019 年到 2026 年，允许 SHARE（和其他 MACS 站点）与九个站点合并将女性机构间艾滋病毒研究 (WIHS) 纳入单一队列，称为 MACS-WIHS 联合队列研究 (CCS)，将包括男性和女性 CCS 的具体目标同时概述。 CCS 假定数据和协调中心 (DACC) 的申请，以及该中心的 10 个具体目标 CCS 的 DACC 申请中概述了单个队列；其中包括心血管 (CV)、肺/睡眠 (PS)、神经认知 NC)、衰老 (AG)、癌症、HIV 发病机制 (PA)、社会心理 (PS)、健康差异、平台 (PL) 和职业发展 (CD) 目标 SHARE Clinical 的具体目标。研究中心 (CRS) 将： 1) 在 CCS 实现其中 7 个目标（即 CV、PS、 AG、PA、PS、PL 和 CD），包括作为超声心动图和睡眠研究的阅读中心 2）有助于实现其他 3 个 CCS 目标，以及 3) 实施所有适用的 CCS 协议和支持 CCS 的科学目标当地关于炎症和身体活动的举措也将支持。这些目标充分利用了生物标本的后续扩展和储存可以从这个群体中获得，并将根据本提案进行扩展，从而为我们的工作做出进一步贡献了解和护理当今艾滋病毒感染者面临的合并症和其他健康问题。