Dissecting the neural circuits of maternal behaviors

剖析母亲行为的神经回路

基本信息

批准号：
10401252
负责人：
Dayu Lin
金额：
$ 48.4万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-10 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10401252
关键词：
Address Aggressive behavior Alpha Cell Animal Model Area Automobile Driving Behavior Cells Characteristics Child Abuse and Neglect Child Development Data Electrophysiology (science)Estrogen Receptor alpha Female Fiber Goals Grooming Health Human Hypothalamic structure In Vitro Infant Investigation Label Mammals Maternal Behavior Medial Mediating Methods Mothers Mus Neurons Neurosciences Optics Output Pathway interactions Pattern Pharmacogenetics Photometry Population Preoptic Areas Research Retrieval Role Series Slice Social Behavior Synapses Tracer Ventral Tegmental Area Viral Work behavioral impairment cell type experience extracellular improved in vivo loss of function maternal caregiving neural circuit neurobehavioral offspring optogenetics public health relevance pup relating to nervous system reproductive response success tool

项目摘要

SUMMARY STATEMENT Across mammalian species, maternal behavior is an innate social behavior essential for the survival and success of the offspring. Decades of research has identified an evolutionarily conserved hypothalamic area, the medial preoptic area (MPOA), as being essential for the expression of maternal behavior. However, given that the MPOA contains heterogeneous and multifunctional cells, the identity of cells relevant for maternal behavior remains unclear. Recently, using a series of state-of-art functional manipulation and in vivo recording tools, we found that cells in the MPOA that express the estrogen receptor alpha (Esr1) are necessary, sufficient and naturally active during maternal behaviors. Our proposed study will expand on these essential findings by seeking to further investigate the neural circuits extended from the population. In Aim 1, we will combine retrograde and antegrade tracing and in vitro slice electrophysiology to identify the downstream targets of the MPOA Esr1+ cells in female mice. In Aim 2, we will employ optogenetic and pharmacogenetic tools to address the functional role of each MPOA pathway and its related downstream cells in driving various components of maternal behaviors. In Aim 3, we will use in vivo optical and electrophysiological recordings to examine the natural responses of cells in the MPOA downstream regions during maternal behaviors, and the principles that underlie the transfer of information from the MPOA to its downstream cells. This project addresses a basic question in neuroscience regarding how maternal behavior is generated and is relevant for understanding and treating a defective maternal circuit that causes abnormal maternal behaviors, such as child neglect and abuse.

概要声明在哺乳动物物种中，母性行为是一种与生俱来的社会行为，对于后代的生存和成功。数十年的研究已经确定了一种进化的下丘脑的保守区域，即内侧视前区（MPOA），对于母亲行为的表达。然而，鉴于 MPOA 包含异构和多功能细胞，与母体行为相关的细胞的身份仍不清楚。最近，使用一系列最先进的功能操作和体内记录工具，我们发现 MPOA 中表达雌激素受体 α (Esr1) 的细胞是必需的，在母亲行为过程中充分且自然活跃。我们提出的研究将扩展通过寻求进一步研究从神经回路延伸出来的这些重要发现人口。在目标1中，我们将结合逆行和顺行追踪以及体外切片电生理学以确定雌性小鼠 MPOA Esr1+ 细胞的下游靶标。在目标 2，我们将利用光遗传学和药物遗传学工具来解决每个 MPOA 通路及其相关下游细胞驱动各种组件母亲的行为。在目标 3 中，我们将使用体内光学和电生理记录来检查母体期间 MPOA 下游区域细胞的自然反应行为以及信息从 MPOA 传输到其自身的原则下游细胞。该项目解决了神经科学中的一个基本问题，即如何母性行为的产生与理解和治疗缺陷相关导致母亲异常行为的母亲回路，例如忽视和虐待儿童。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.

转录定义的杏仁核亚群在先天社会行为中发挥着独特的作用。

DOI：
发表时间：
2023-12
期刊：
影响因子：
25
作者：
Lischinsky, Julieta E;Yin, Luping;Shi, Chenxi;Prakash, Nandkishore;Burke, Jared;Shekaran, Govind;Grba, Maria;Corbin, Joshua G;Lin, Dayu
通讯作者：
Lin, Dayu

VMHvllCckar cells dynamically control female sexual behaviors over the reproductive cycle.

VMHvllCckar 细胞在生殖周期中动态控制女性性行为。

DOI：
发表时间：
2022-09-21
期刊：
影响因子：
16.2
作者：
Yin, Luping;Hashikawa, Koichi;Hashikawa, Yoshiko;Osakada, Takuya;Lischinsky, Julieta E;Diaz, Veronica;Lin, Dayu
通讯作者：
Lin, Dayu

Hardwired to attack: Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.

天生容易受到攻击：转录定义的杏仁核亚群在先天社会行为中发挥着独特的作用。

DOI：
发表时间：
2023-03-17
期刊：
影响因子：
0
作者：
Lischinsky, Julieta E;Yin, Luping;Shi, Chenxi;Prakash, Nandkishore;Burke, Jared;Shekaran, Govind;Grba, Maria;Corbin, Joshua G;Lin, Dayu
通讯作者：
Lin, Dayu

Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit.

下丘脑-中脑回路中攻击性的分层表示。

DOI：
发表时间：
2020
期刊：
影响因子：
16.2
作者：
Falkner, Annegret L;Wei, Dongyu;Song, Anjeli;Watsek, Li W;Chen, Irene;Chen, Patricia;Feng, James E;Lin, Dayu
通讯作者：
Lin, Dayu

A dedicated hypothalamic oxytocin circuit controls aversive social learning.

专门的下丘脑催产素回路控制厌恶的社交学习。

DOI：
10.1038/s41586-023-06958-w
发表时间：
2024-01-24
期刊：
Nature
影响因子：
64.8
作者：
Takuya Osakada;Rongzhen Yan;Yiwen Jiang;Don Wei;Rina Tabuchi;Bing Dai;Xiaohan Wang;Gavin Zhao;Clara Xi Wang;Jing;Richard W Tsien;Adam C Mar;Dayu Lin
通讯作者：
Dayu Lin