Advanced Immunobiology Traning Program for Surgeons
外科医生高级免疫生物学培训计划
基本信息
- 批准号:10396460
- 负责人:
- 金额:$ 26.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-06-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Project Summary/Abstract
Immunobiology has become increasingly relevant to surgical practice, influencing diverse disciplines including
oncology, inflammatory bowel disease, transplantation, trauma and critical care. Although the importance of
immune manipulation has become an evident adjunct to surgical practice, surgical training neither includes
advanced immunology nor prepares surgeon-scientists to participate in immune-related research. This training
grant application seeks funding for the formation of the Advanced Immunobiology Training Program (AITP) at
Duke University to create surgeon-scientists capable of participating in and leading surgically relevant areas of
immunobiological research. The training program will combine the substantial academic rigor of the Duke
University School of Medicine with the Duke Department of Surgery's longstanding and highly successful
commitment to training the next generation of surgical researchers. The program will be co-directed by an
academic surgeon and a basic sciences researcher, each with expertise in immunology. Supplemented by
mentors with expertise in basic, translational, and clinical research, this multidisciplinary team is uniquely
qualified to merge basic and applied immunobiology with evolving surgical practice. Program participants will
consist of postdoctoral trainees who have completed medical school and initiated surgical residency. At least
six individuals will be trained during the proposed funding period. Based on individual development plans, each
trainee will choose to participate in either a two- or three-year training program, with opportunities to complete
a Master of Health Sciences degree in Clinical Research, or pursue a PhD in Immunology. Trainees will select
a primary mentor from a highly experienced and diverse group of 16 basic, translational or clinical
immunobiological researchers. Guided by their mentor, they will follow a structured didactic curriculum that will
transition to a mentored research experience. A robust research infrastructure and substantial departmental
resources will support the students, facilitating their conduct and publication of original investigations with
complete protection from clinical service. Specific instruction in immunological investigation will be provided, as
will mentorship in scientific writing, publication, ethics and clinical time management.
项目概要/摘要
免疫生物学与外科实践越来越相关,影响着不同的学科,包括
肿瘤学、炎症性肠病、移植、创伤和重症监护。虽然重要性
免疫操作已成为外科手术的明显辅助手段,但外科培训也不包括
先进的免疫学也不能让外科医生科学家做好参与免疫相关研究的准备。本次培训
拨款申请为高级免疫生物学培训计划(AITP)的形成寻求资金
杜克大学将培养能够参与和领导外科相关领域的外科医生科学家
免疫生物学研究。该培训计划将结合杜克大学的学术严谨性
大学医学院与杜克大学外科系历史悠久且非常成功
致力于培训下一代外科研究人员。该计划将由
学术外科医生和基础科学研究人员,每个人都拥有免疫学方面的专业知识。补充为
这个多学科团队的导师拥有基础、转化和临床研究方面的专业知识,是独一无二的
有资格将基础和应用免疫生物学与不断发展的外科实践相结合。计划参与者将
由完成医学院学业并开始外科住院医师培训的博士后学员组成。至少
在拟议供资期间将培训六人。各人根据个人发展规划
学员将选择参加两年或三年的培训计划,并有机会完成
临床研究健康科学硕士学位,或攻读免疫学博士学位。学员将选择
来自经验丰富且多元化的 16 名基础、转化或临床团队的主要导师
免疫生物学研究人员。在导师的指导下,他们将遵循结构化的教学课程
过渡到指导研究经验。强大的研究基础设施和大量的部门
资源将支持学生,促进他们进行和发表原始调查
全面保障临床服务。将提供免疫学研究的具体指导,如
将在科学写作、出版、道德和临床时间管理方面提供指导。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Allan D. Kirk其他文献
The Role of Donor‐Specific HLA Alloantibodies in Liver Transplantation
供体特异性 HLA 同种抗体在肝移植中的作用
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:8.8
- 作者:
Jacqueline G. O’Leary;A. Demetris;Lawrence S. Friedman;Howard M. Gebel;P. Halloran;Allan D. Kirk;Stuart J. Knechtle;S. McDIARMID;Abraham Shaked;Terasaki Pi;K. Tinckam;S. Tomlanovich;Kathryn J. Wood;E. Woodle;A. Zachary;Göran B. Klintmalm - 通讯作者:
Göran B. Klintmalm
Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates.
使用人源化 CD154 特异性单克隆抗体 hu5C8 进行治疗可预防非人灵长类动物原发皮肤同种异体移植物的急性排斥反应。
- DOI:
10.1097/00007890-200111150-00001 - 发表时间:
2001-11-15 - 期刊:
- 影响因子:6.2
- 作者:
Eric A. Elster;He Xu;D. Tadaki;Sean P. Montgomery;L. Burkly;J. Berning;R. Baumgartner;F. Cruzata;Richard Marx;David M. Harlan;Allan D. Kirk;Allan D. Kirk - 通讯作者:
Allan D. Kirk
Prediction of venous thromboembolism using clinical and serum biomarker data from a military cohort of trauma patients
使用创伤患者军事队列的临床和血清生物标志物数据预测静脉血栓栓塞
- DOI:
10.1136/bmjmilitary-2019-001393 - 发表时间:
2020-03-05 - 期刊:
- 影响因子:1.5
- 作者:
M. Bradley;Audrey Shi;V. Khatri;S. Schobel;E. Silvius;Allan D. Kirk;T. Buchman;John S. Oh;Eric A. Elster - 通讯作者:
Eric A. Elster
Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
用人源化抗 CD154 治疗的狒狒肝内胰岛同种异体移植物的长期存活和功能。
- DOI:
10.2337/diabetes.48.7.1473 - 发表时间:
1999-07-01 - 期刊:
- 影响因子:7.7
- 作者:
Norma S. Kenyon;L. Fern;ez;ez;R. Lehmann;Michele Masetti;A. Ranuncoli;M. Chatzipetrou;Giuseppe Iaria;Dongmei Han;Joseph L. Wagner;Philip Ruiz;Mariana Berho;L. Inverardi;Rodolfo Alej;ro;ro;Daniel H. Mintz;Allan D. Kirk;David M. Harlan;L. Burkly;Camillo Ricordi - 通讯作者:
Camillo Ricordi
Infant pediatric liver transplantation results equal those for older pediatric patients.
婴儿儿科肝移植结果与老年儿科患者相同。
- DOI:
- 发表时间:
1998 - 期刊:
- 影响因子:2.4
- 作者:
W. Werf;A. D’ALESSANDRO;S. Knechtle;Gokhan Pilli;R. Hoffmann;Robert H. Judd;Jon S. Odorico;Allan D. Kirk;Stephen C. Rayhill;H. Sollinger;M. Kalayoglu - 通讯作者:
M. Kalayoglu
Allan D. Kirk的其他文献
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{{ truncateString('Allan D. Kirk', 18)}}的其他基金
Advanced Immunobiology Traning Program for Surgeons
外科医生高级免疫生物学培训计划
- 批准号:
10598547 - 财政年份:2019
- 资助金额:
$ 26.24万 - 项目类别:
Depletion, Repopulation and Tolerance in Non-Sensitied Recipients
非敏感受体的消耗、再生和耐受性
- 批准号:
10649945 - 财政年份:2017
- 资助金额:
$ 26.24万 - 项目类别:
Depletion, Repopulation and Tolerance in Non-Sensitied Recipients
非敏感受体的消耗、再生和耐受性
- 批准号:
9980790 - 财政年份:2017
- 资助金额:
$ 26.24万 - 项目类别:
Depletion, Repopulation and Tolerance in Non-Sensitied Recipients
非敏感受体的消耗、再生和耐受性
- 批准号:
10214495 - 财政年份:2017
- 资助金额:
$ 26.24万 - 项目类别:
Cell Adhesion and Trafficking as a Therapeutic Target in Allotransplantation
细胞粘附和运输作为同种异体移植的治疗靶点
- 批准号:
8705985 - 财政年份:2014
- 资助金额:
$ 26.24万 - 项目类别:
T Cell Maturation and the Nexus of Viral- and Allo-Immunity
T 细胞成熟以及病毒免疫和同种异体免疫的关系
- 批准号:
8371823 - 财政年份:2012
- 资助金额:
$ 26.24万 - 项目类别:
T Cell Maturation and the Nexus of Viral- and Allo-Immunity
T 细胞成熟以及病毒免疫和同种异体免疫的关系
- 批准号:
8607811 - 财政年份:2012
- 资助金额:
$ 26.24万 - 项目类别:
T Cell Maturation and the Nexus of Viral- and Allo-Immunity
T 细胞成熟以及病毒免疫和同种异体免疫的关系
- 批准号:
8463978 - 财政年份:2012
- 资助金额:
$ 26.24万 - 项目类别:
ADJUVANT THERAPIES IMPROVING ANTI-REJECTION EFFECTS OF COSTIMULATION BLOCKADE
辅助疗法改善共同刺激封锁的抗排斥效果
- 批准号:
8357527 - 财政年份:2011
- 资助金额:
$ 26.24万 - 项目类别:
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