Inverse Methods for Spatiotemporal Characterization of Gastric Electrical Activity and its Association with Upper GI Symptoms from Cutaneous Multi-electrode Recordings

皮肤多电极记录胃电活动时空特征及其与上消化道症状关联的逆向方法

基本信息

  • 批准号:
    10394942
  • 负责人:
  • 金额:
    $ 7.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-05-01 至 2023-02-28
  • 项目状态:
    已结题

项目摘要

Project Summary Gastrointestinal (GI) problems are the second leading cause for missing work or school, giving rise to 10 percent of reasons a patient visits their primary care physician and costing $142 billion annually in the US. A majority of such cases are referred to GI specialists, where endoscopy, imaging, and blood tests allow for easy diagnosis of blockages and infections. However, more than half of GI disorders involve abnormal neuromuscular functioning of the GI tract, occurring in a majority of Parkinson’s and diabetes patients for instance. Diagnosis of such GI disorders typically entails subjective symptom-based questionnaires or objective but invasive procedures in specialized centers. Symptom-based diagnosis is problematic because many GI functional disorders with different treatment regimens have overlapping symptoms. Invasive approaches performed in specialized centers can differentiate between myopathic and neuropathic functional disorders and can change the diagnosis/treatment of 15% to 20% of patients with upper GI symptoms. However, they have drawbacks of cost and invasiveness: gastric scintigraphy with its radioactive imaging; manometry, which involves a catheter inserted through the mouth or nose with fluoroscopic or endoscopic guidance. Long wait times and intermittent monitoring associated with assessment of neuromuscular GI disorders, coupled with a strong preference by patients for non-invasive testing instead of current approaches, pinpoints the non-trivial challenges associated with scaling up GI assessment with specialized centers. Altogether, the non-existence of an objective, non-invasive, way to monitor functional GI disorders and their association with transient symptoms is a significant drawback that has vast economic, social, and healthcare consequences. We have developed and demonstrated a procedure that uses a non-invasive multi-electrode sensor array along with a suite of statistical signal processing methods that objectively provide wave propagation descriptions of GI neuromuscular functions that correlate with symptoms. Additionally, using this multi-electrode array we have developed novel Bayesian inference methods to source localize the gastric slow wave on the stomach surface. In this project, we will advance our source localization method to reduce the requirement of human intervention and then apply our method to an existing set of subjects for whom we have already collected data. This project is an important step towards validation of a quantifiable non-invasive measure for gastric health that can help modernize functional gastroenterology. It promotes an inexpensive, non-invasive technology coupled with novel signal processing methods that may lead to transformational clinical approaches that allow for understanding disease etiology, assessing disease progression, and predicting treatment response.
项目概要 胃肠道 (GI) 问题是导致缺勤或缺课的第二大原因,导致 10 在美国,患者去看初级保健医生的原因占 1%,每年花费 1,420 亿美元。 大多数此类病例都会转诊给胃肠道专家,内窥镜检查、影像学和血液检查可以轻松诊断 然而,超过一半的胃肠道疾病涉及异常。 胃肠道的神经肌肉功能,发生在大多数帕金森病和糖尿病患者中 例如,此类胃肠道疾病的诊断通常需要基于主观症状的问卷调查或。 在专门的中心进行客观但侵入性的诊断是有问题的,因为 许多胃肠道功能性疾病在不同的治疗方案中都有重叠的症状。 在专门中心进行的方法可以区分肌病性和神经病性功能性 疾病,并可以改变 15% 至 20% 上消化道症状患者的诊断/治疗。 然而,它们具有成本和侵入性的缺点:胃闪烁扫描及其放射性成像; 测压,涉及通过荧光镜或内窥镜将导管插入口腔或鼻子 与神经肌肉胃肠道评估相关的长时间等待和间歇性监测。 疾病,加上患者强烈偏好非侵入性检测而不是当前的方法, 指出了与专业中心扩大胃肠道评估相关的重大挑战。 总而言之,不存在一种客观的、非侵入性的方法来监测功能性胃肠道疾病及其影响 与短暂症状相关是一个重大缺陷,对经济、社会和医疗保健都有巨大影响 我们开发并演示了一种使用非侵入性多电极的程序。 传感器阵列以及一套客观提供波的统计信号处理方法 与症状相关的胃肠道神经肌肉功能的传播描述。 多电极阵列,我们开发了新颖的贝叶斯推理方法来定位胃慢速 在这个项目中,我们将改进我们的源定位方法以减少胃表面的波。 人类干预的要求,然后将我们的方法应用于我们有的一组现有受试者 该项目是验证可量化非侵入性的重要一步。 胃健康的措施可以帮助实现功能性胃肠病学的现代化。 非侵入性技术与新颖的信号处理方法相结合,可能会带来变革 允许了解疾病病因、评估疾病进展的临床方法,以及 预测治疗反应。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Exploring the Gut-Brain Connection in Gastroparesis with Autonomic and Gastric Myoelectric Monitoring.
通过自主神经和胃肌电监测探索胃轻瘫的肠-脑连接。
  • DOI:
  • 发表时间:
    2023-06-13
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Subramanian, Sandya;Kunkel, David C;Nguyen, Linda;Coleman, Todd P
  • 通讯作者:
    Coleman, Todd P
Robust Regression and Optimal Transport Methods to Predict Gastrointestinal Disease Etiology From High Resolution EGG and Symptom Severity.
通过高分辨率 EGG 和症状严重程度预测胃肠道疾病病因的稳健回归和最佳传输方法。
  • DOI:
  • 发表时间:
    2022-11
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Agrusa, Anjulie S;Kunkel, David C;Coleman, Todd P
  • 通讯作者:
    Coleman, Todd P
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Todd P Coleman其他文献

Todd P Coleman的其他文献

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{{ truncateString('Todd P Coleman', 18)}}的其他基金

Traveling waves in neocortical circuits: Mechanisms, computational roles in sensory processing, and impact on sensory perception
新皮质回路中的行波:感觉处理中的机制、计算作用以及对感觉知觉的影响
  • 批准号:
    10655101
  • 财政年份:
    2023
  • 资助金额:
    $ 7.9万
  • 项目类别:
iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
iGLAMOUR 研究:青光眼依从性和监测代表性不足的少数群体的创新
  • 批准号:
    10330002
  • 财政年份:
    2021
  • 资助金额:
    $ 7.9万
  • 项目类别:
Inverse Methods for Spatiotemporal Characterization of Gastric Electrical Activity and its Association with Upper GI Symptoms from Cutaneous Multi-electrode Recordings
皮肤多电极记录胃电活动时空特征及其与上消化道症状关联的逆向方法
  • 批准号:
    10196836
  • 财政年份:
    2021
  • 资助金额:
    $ 7.9万
  • 项目类别:
Programmable evolution of optogenetic systems
光遗传学系统的可编程进化
  • 批准号:
    10318056
  • 财政年份:
    2021
  • 资助金额:
    $ 7.9万
  • 项目类别:
Programmable evolution of optogenetic systems
光遗传学系统的可编程进化
  • 批准号:
    10480900
  • 财政年份:
    2021
  • 资助金额:
    $ 7.9万
  • 项目类别:
iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
iGLAMOUR 研究:青光眼依从性和监测代表性不足的少数群体的创新
  • 批准号:
    10549804
  • 财政年份:
    2021
  • 资助金额:
    $ 7.9万
  • 项目类别:
Programmable evolution of optogenetic systems
光遗传学系统的可编程进化
  • 批准号:
    10623650
  • 财政年份:
    2021
  • 资助金额:
    $ 7.9万
  • 项目类别:
A Novel Model System for Restoring Hearing in vivo
一种恢复体内听力的新型模型系统
  • 批准号:
    10224166
  • 财政年份:
    2020
  • 资助金额:
    $ 7.9万
  • 项目类别:
A Novel Model System for Restoring Hearing in vivo
一种恢复体内听力的新型模型系统
  • 批准号:
    10058225
  • 财政年份:
    2020
  • 资助金额:
    $ 7.9万
  • 项目类别:
SCH: Interface Monitoring System to Promote Residual Limb Health
SCH:促进残肢健康的接口监控系统
  • 批准号:
    9313641
  • 财政年份:
    2014
  • 资助金额:
    $ 7.9万
  • 项目类别:

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Heterogeneity in joint real-time and developmental influences of positive and negative social media experiences on socioemotional vulnerability and psychopathology across adolescence
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