OXYGEN TRANSPORT & HEMODYNAMICS IN THE MICROVASCULATURE

氧气输送

• 批准号: 2210249
• 负责人: MARY L ELLSWORTH
• 金额: $ 6.54万
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-01-01 至 1996-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2210249
• 关键词: bioenergetics; diffusion; hamsters; hemodynamics; hemoglobin; hypoxia; microcirculation; muscle function; oxygen transport; striated muscles

My current research is focused on understanding the relative contributions of convective and diffusive processes governing oxygen delivery, in particular how increasing the affinity of the hemoglobin molecule for oxygen impacts on oxygen exchange. The initial series of studies proposed here will enable us to better characterize the diffusional interactions between large microvessels (arterioles and venules) and the capillaries under normoxic and hypoxic conditions, with and without a decrease in systemic hematocrit. The next two series of studies will enable us to explore the impact of an increased hemoglobin oxygen affinity on oxygen transport in the presence of an elevated oxygen demand with and without reduced levels of inspired oxygen tension and systemic hematocrit, thereby testing the limits of oxygen delivery in this system.

我目前的研究重点是了解亲戚 控制氧气的对流和扩散过程的贡献 递送，特别是如何增加血红蛋白的亲和力 氧分子对氧交换的影响。 最初的系列 这里提出的研究将使我们能够更好地描述 大型微血管（小动脉和 静脉）和毛细血管在常氧和低氧条件下，具有 并且没有系统性血细胞比容的减少。 接下来的两个系列 研究将使我们能够探索增加血红蛋白的影响 在升高的情况下，氧气的氧气亲和力 氧气需求有和没有降低的氧气张力水平 和全身血细胞比容，从而测试氧递送的极限 在这个系统中。