Engaging Young People who Inject Drugs into HCV and HIV Care

让注射毒品的年轻人参与丙型肝炎和艾滋病毒护理

• 批准号: 10392902
• 负责人: Sabrina A Assoumou
• 金额: $ 18.15万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392902
• 关键词: Acquired Immunodeficiency Syndrome; Acute; Address; Affect; Age-Years; Boston; Caring; Case Management; Client; Clinical; Clinical Trials; Communicable Diseases; Continuity of Patient Care; Data Set; Development; Development Plans; Disease Outbreaks; Drug Metabolic Detoxication; Environment; Epidemic; Evidence based intervention; Faculty; Feasibility Studies; Fellowship; Foundations; Funding; Future; Goals; HIV; HIV diagnosis; HIV/HCV; Health Personnel; Healthcare Systems; Hepatitis C; Hepatitis C Therapy; Hepatitis C virus; Hospitals; Human immunodeficiency virus test; Indiana; Individual; Infection; Injecting drug user; Institute of Medicine (U.S.); Internal Medicine; Intervention; Interview; Israel; Learning; Link; Location; Medical center; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modeling; Newly Diagnosed; Outcome; Patients; Pediatrics; Persons; Pharmaceutical Preparations; Phase; Pilot Projects; Population; Preparation; Prevention; Procedures; Publications; Publishing; Qualitative Research; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Resources; Scientist; Self Efficacy; Social Work; Statistical Methods; Target Populations; Techniques; Testing; Training; Twin Multiple Birth; United States; United States National Institutes of Health; Universities; Vulnerable Populations; Work; World Health Organization; acceptability and feasibility; addiction; aged; base; career; career development; cost effectiveness; design; drug testing; effective therapy; evidence base; experience; health care availability; health care delivery; implementation intervention; improved; improved outcome; injection drug use; innovation; medical schools; meetings; pilot test; prevention service; programs; skills; substance use; substance use treatment; success; therapy development; transmission process; treatment services; young adult

PROJECT SUMMARY / ABSTRACT Background: Recent human immunodeficiency virus (HIV) and hepatitis C virus (HCV) outbreaks, including the one in Indiana, illustrate that these infections should be addressed simultaneously to improve outcomes. In the United States most of the new HCV infections are among young people who inject drugs (PWID). Studies at detoxification centers have shown that linkage to care is problematic. Social services support such as case management has the potential to improve linkage to care; however, little is known about its potential influence on the care of young PWID. Candidate: I am a clinician scientist trained in combined internal medicine/pediatrics and infectious diseases (ID). I am committed to investigating strategies to improve health care delivery to HCV- and HIV-infected individuals. After completing an ID fellowship at Harvard's Beth Israel Deaconess Medical Center, I joined the faculty at Boston University (BU) School of Medicine, where I have gained experience working with substance using patients. I am applying for a 5-year K23 award to acquire the necessary skills and experience to become an independently funded clinician investigator with expertise to design, implement and analyze clinical interventions. Research: I will use the ADAPT-ITT framework to modify strengths-based case management (SBCM), an evidence-based linkage to care intervention, to address the needs of PWID aged 18 to 30 tested for HCV and HIV at a detoxification center. I will then pilot test the adapted intervention. The specific aims are to (1) To use in-depth, qualitative interviews to identify facilitators and barriers to linkage and retention in HIV and/or HCV care; (2) To use findings from Aim 1 to adapt SBCM to improve linkage and retention in care; 3) To conduct a feasibility study of the adapted intervention in preparation for a future trial. Training: The career development plan includes training in the development of interventions, clinical trials, advanced statistical methods, and substance use research. The BU ID department, the Centers for AIDS Research (CFAR) and the NIH-funded Learning for Early Careers in Addiction and Diversity program provide a rich research environment. Mentorship: My primary mentor, Dr. Samet, has expertise in substance use, HIV and HCV. Dr. Linas, my co-mentor, has expertise in HCV, HIV and linkage to care. Advisors are Drs. Bernstein (qualitative research), Horsburgh (HCV and HIV) and Sorensen (substance use and HIV). At the completion of my K23, I will have gained the skills necessary to become an independent clinician investigator focusing on HCV and HIV linkage to care among individuals with a history of substance use.

项目概要/摘要 背景：最近人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）的爆发，包括 印第安纳州的案例表明，应该同时解决这些感染以改善结果。在 美国大部分新增丙肝病毒感染者是注射吸毒的年轻人（PWID）。研究 戒毒中心的情况表明，与护理的联系存在问题。案例等社会服务支持 管理有潜力改善与护理的联系；然而，对其潜在影响知之甚少 关于年轻注射吸毒者的护理。候选人：我是一名接受过综合内科培训的临床科学家 医学/儿科和传染病（ID）。我致力于研究改善健康的策略 向 HCV 和 HIV 感染者提供护理。在哈佛大学贝斯以色列完成 ID 奖学金后 女执事医疗中心，我加入了波士顿大学 (BU) 医学院，在那里我 获得了与药物滥用患者一起工作的经验。我正在申请 5 年 K23 奖项以获得 成为独立资助的临床研究者所需的技能和经验，具有专业知识 设计、实施和分析临床干预措施。研究：我会使用ADAPT-ITT框架来修改 基于优势的案例管理（SBCM），一种与护理干预的基于证据的联系，以解决 18 至 30 岁的注射吸毒者需要在戒毒中心接受 HCV 和 HIV 检测。然后我将进行试点测试 适应性干预。具体目标是 (1) 使用深入、定性的访谈来确定促进者 HIV 和/或 HCV 护理中联系和保留的障碍； (2) 利用目标 1 的发现使 SBCM 适应 改善护理的联系和保留； 3）对适应的干预措施进行可行性研究 为将来的试验做准备。培训：职业发展计划包括发展培训 干预措施、临床试验、先进的统计方法和物质使用研究。 BU ID 部门， 艾滋病研究中心 (CFAR) 和美国国立卫生研究院 (NIH) 资助的成瘾早期职业学习中心 多样性项目提供了丰富的研究环境。指导：我的主要导师 Samet 博士 药物滥用、艾滋病毒和丙型肝炎方面的专业知识。我的共同导师 Linas 博士拥有 HCV、HIV 及其关联方面的专业知识 关心。顾问是博士。 Bernstein（定性研究）、Horsburgh（HCV 和 HIV）和 Sorensen（物质研究） 使用和艾滋病毒）。完成 K23 后，我将获得成为独立人士所需的技能 临床研究者专注于丙型肝炎病毒和艾滋病毒与有物质史的个体护理之间的联系 使用。

项目成果

Development and Validation of the HIV-CARDIO-PREDICT Score to Estimate the Risk of Cardiovascular Events in HIV-Infected Patients.

开发和验证 HIV-CARDIO-PREDICT 评分，以估计 HIV 感染患者发生心血管事件的风险。

• 发表时间: 2023-02-05
• 影响因子: 6
• 作者: Karanika, Styliani;Karantanos, Theodoros;Carneiro, Herman;Assoumou, Sabrina A
• 通讯作者: Assoumou, Sabrina A

Addressing Inequities in SARS-CoV-2 Vaccine Uptake: The Boston Medical Center Health System Experience.

解决 SARS-CoV-2 疫苗接种方面的不平等问题：波士顿医疗中心卫生系统经验。

• 发表时间: 2022-06
• 影响因子: 39.2
• 作者: Assoumou, Sabrina A;Peterson, Alicia;Ginman, Ellen;James, Thea;Pierre, Cassandra M;Hamilton, Sebastian;Chapman, Sheila;Goldie, John;Koenig, Robert;Mendez;Leaver, Hannah;Graham, Robert;Crichlow, Renee;Weaver, Tarsha;Cotterell
• 通讯作者: Cotterell

Sexually Transmitted and Blood-borne Infections Among Patients Presenting to a Low-barrier Substance Use Disorder Medication Clinic.

低门槛药物使用障碍药物诊所患者的性传播感染和血源性感染。

• 发表时间: 2021-11-01
• 作者: Harvey, Leah;Taylor, Jessica L;Assoumou, Sabrina A;Kehoe, Jessica;Schechter;Bernstein, Edward;Walley, Alexander Y
• 通讯作者: Walley, Alexander Y

Addressing Unmet PrEP Needs in Women: Impact of a Laboratory-Driven Protocol at an Urban, Essential Hospital.

解决女性未满足的 PrEP 需求：实验室驱动方案对城市基础医院的影响。

• 发表时间: 2024-03
• 影响因子: 4.2
• 作者: Stewart, Jessica;Ruiz;Sperring, Heather;Pierre, Cassandra M;Assoumou, Sabrina A;Taylor, Jessica L
• 通讯作者: Taylor, Jessica L