Facility and Building System Upgrades Support for the Howard T. Ricketts Biocontainment Laboratory

为 Howard T. Ricketts 生物防护实验室提供设施和建筑系统升级支持

• 批准号: 10394614
• 负责人: Erin June Adams
• 金额: $ 329.97万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394614
• 关键词: 2019-nCoV; Anthrax disease; Bacillus; Biomedical Research; Brucella; Centers for Disease Control and Prevention (U.S.); Chicago; County; Coxiella; Department of Energy; Development; ESKAPE pathogens; Ensure; Equipment; Goals; Humidity; Illinois; Infectious Agent; Influenza; Institution; Laboratories; Life; Microbiology; Operations Research; Organism; Pathogenicity; Plague; Regulation; Research; Research Support; Rickettsia; Site; Students; Surveillance Program; Swelling; System; Temperature; Testing; Training Programs; Universities; Yersinia; emerging pathogen; experimental study; laboratory experiment; methicillin resistant Staphylococcus aureus; new technology; novel therapeutics; novel vaccines; pathogen; pathogenic virus; pressure; programs; research facility

Project Summary/Abstract The Howard Taylor Ricketts Laboratory (HTRL) is a state-of-the-art Regional Biocontainment Laboratory on the Argonne National Laboratory (ANL) campus in DuPage County, Illinois. Located twenty-five miles southwest from the University of Chicago campus, ANL is a federally (Department of Energy) owned site operated by the University of Chicago (UCHICAGO LLC). HTRL is a CDC certified facility owned by the University of Chicago and operated by the Department of Microbiology. Biosafety training and surveillance program involving classroom and laboratory activities ensures that staff, students and fellows comply with state and federal regulations to safely operate facilities and experiments with RG2, RG3 and Select Agent pathogens. The HTRL construction was completed in 2008. Over the last 13 years, the HTRL has hosted research programs studying the bacterial species Yersinia, Brucella, Coxiella, Rickettsia, Bacilli, MRSA and other ESKAPE organisms, as well as viral pathogens including low and highly pathogenic influenza, DENGUE and more recently SARS-CoV2. The facility currently hosts research program on Plague, Anthrax and MRSA, as well as a Core Research Facility for SARS-CoV2. The HTRL is the largest A-BSL3 holding facility in the region and regularly supports research from consortium institutions including UIC, Northwestern U and Loyola U. The HTRL is fulfilling its goal as a biomedical research facility that can rapidly respond to research needs and support biomedical research on emerging and re-emerging pathogens, discovery and testing of new therapeutics and vaccines. The building has been maintained in excellent working conditions and has been in constant use since its construction. However, with the swelling demands for BSL3 and ABSL3 space and research expertise, the development of new technologies for the study of infectious agents, this proposal is a request (i) to upgrade system components necessary to maintain biocontainment, temperature/humidity/pressurization requirements, and safe research operations, and (ii) to replace research equipment that have either outlived the intended useful life or no longer meet facility requirements.

项目概要/摘要 霍华德·泰勒·里基茨实验室 (HTRL) 是最先进的区域生物防护实验室 位于伊利诺伊州杜佩奇县阿贡国家实验室 (ANL) 园区的实验室。 ANL 位于芝加哥大学校园西南二十五英里处，是联邦大学 （能源部）拥有的网站由芝加哥大学 (UCHICAGO LLC) 运营。 HTRL 是 CDC 认证的设施，由芝加哥大学拥有并由 微生物学系。涉及课堂的生物安全培训和监测计划 和实验室活动确保工作人员、学生和研究员遵守州和联邦的规定 安全操作 RG2、RG3 和 Select Agent 设施和实验的法规 病原体。 HTRL于2008年竣工。在过去的13年里，HTRL 主持了研究细菌种类耶尔森氏菌、布鲁氏菌、柯克斯氏菌的研究项目， 立克次体、杆菌、MRSA 和其他 ESKAPE 生物，以及病毒病原体，包括 低致病性和高致病性流感、登革热以及最近的 SARS-CoV2。设施 目前主持有关鼠疫、炭疽和 MRSA 的研究项目以及核心研究 SARS-CoV2 设施。 HTRL 是该地区最大的 A-BSL3 持有设施， 定期支持 UIC、西北大学和 洛约拉大学 HTRL 正在实现其作为生物医学研究机构的目标，能够迅速 响应研究需求并支持新兴和重新新兴的生物医学研究 病原体、新疗法和疫苗的发现和测试。该建筑已被 保持良好的工作条件，自建成以来一直在持续使用。 然而，随着对 B​​SL3 和 ABSL3 空间和研究专业知识的需求不断增长， 开发用于研究传染性病原体的新技术，该提案是一个请求（i） 升级维持生物防护所需的系统组件， 温度/湿度/压力要求和安全研究操作，以及 (ii) 更换已经超过预期使用寿命或不再满足要求的研究设备 设施要求。