CARDIOVASCULAR ACTIONS OF PUTATIVE TRANSMITTERS

假定发射器的心血管作用

• 批准号: 2215737
• 负责人: HREDAY N. SAPRU
• 金额: $ 18.6万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2215737
• 关键词: acetylcholine; afferent nerve; alpha adrenergic receptor; brain stem; cardiovascular function; chemoreceptors; gamma aminobutyrate; hormone regulation /control mechanism; hypertension; laboratory rat; medulla oblongata; neurochemistry; neurons; neuropharmacology; neurotransmitters; norepinephrine; solitary tract nucleus; spinal cord; stroke

High blood pressure and stroke afflict 10-30% of the adult population in this country. The mechanisms of cardiovascular complications in these conditions are not clearly understood. In order to unravel these mechanisms, it is necessary to know how different "neuronal pools" in the central nervous system regulate cardiovascular function normally. Information available on these mechanisms is incomplete. The long-term goal of this grant application is to gain a better understanding of the central regulation of cardiovascular function. Eventually the information generated from these investigations is likely to be useful in the treatment of cardiovascular disorders such as hypertension and stroke. During the previous funding periods, cardiovascular reflex mechanisms were studied in normotensive and hypertensive animals. This was followed by the functional identification of the pathways and neurotransmitters involved in these reflexes. Cardiovascular pressor and depressor areas in the brainstem and sympathoexcitatory areas in athe spinal cord were then identified in normotensive animals. In the present proposal, which is a logical extension of previous studies, functional relationship between different brainstem cardiovascular areas, their interaction with intermediolateral cell column of the thoraco-lumbar spinal cord and identification of putative neurotransmitters in the pathways interconnecting these cardiovascular regulatory mechanisms will be investigated. There are several gaps in our knowledge on this topic. These issues will be addressed in the following specific aims: 1) Identification of the neurotransmitters and pathways mediating carotid chemoreceptor reflex in the ventrolateral medulla and the spinal cord. 2) Investigation of the modulatory role of alpha adrenergic receptors at the target sites of the projection from rostral ventrolateral medulla to the spinal cord. 30 Functional identification of other cell groups (e.g. A5 noradrenergic cells) in the brainstem sending projections to the intermediolateral cell column in which norepinephrine may be the modulator.

10-30%的成年人口患有高血压和中风 这个国家。 这些心血管并发症的机制 条件不清楚。 为了解开这些 机制，有必要了解不同的“神经元池”如何 中枢神经系统正常调节心血管功能。 有关这些机制的可用信息不完整。 长期来看 这项拨款申请的目标是更好地了解 心血管功能的中枢调节。 最终得到的信息 这些调查产生的结果可能有助于治疗 高血压和中风等心血管疾病。 期间 之前的资助期间，心血管反射机制的研究 血压正常和高血压的动物。 接下来是功能性的 鉴定参与这些的途径和神经递质 反射。 脑干中的心血管升压区和降压区 然后确定了脊髓中的交感兴奋区域 血压正常的动物。 在目前的提案中，这是一个合乎逻辑的 以前研究的延伸，不同之间的功能关系 脑干心血管区域，它们与中间外侧的相互作用 胸腰段脊髓细胞柱及其鉴定 连接这些通路的假定神经递质 将研究心血管调节机制。 有 我们在这个主题上的知识存在一些空白。 这些问题将会 解决以下具体目标： 1) 识别 介导颈动脉化学感受器反射的神经递质和通路 腹外侧延髓和脊髓。 2) 调查 α肾上腺素能受体在靶位点的调节作用 从延髓头侧腹外侧到脊髓的投影。 30 其他细胞群的功能鉴定（例如 A5 去甲肾上腺素能细胞） 脑干细胞）向中间外侧细胞发送投射 其中去甲肾上腺素可能是调节剂。