CAFFEINE INFLUENCES ON EXERCISE AND PSYCHOLOGICAL STRESS

咖啡因对运动和心理压力的影响

• 批准号: 2216943
• 负责人: William R Lovallo
• 金额: $ 33.9万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2216943
• 关键词: blood pressure; caffeine; cardiovascular function; cardiovascular stress test; cortisol; dosage; drug tolerance; echocardiography; exercise; human subject; neuroendocrine system; physiologic stressor; psychological stressor; psychomotor function; psychopharmacology; stress

DESCRIPTION: The objective of this work is to develop a base of information about the effects of caffeine on cardiovascular and neuroendocrine functions during rest and during mental and exercise stressors. Caffeine is widely used in pharmacologically significant quantities. It affects the central nervous system, cardiovascular activity, and neuroendocrine function. Consumption may increase during times of mental stress, and it is often present during exercise. Caffeine has been shown to increase cardiovascular disease risk factors such as serum cholesterol and lipid fractions. However, the potential effects of caffeine may be reduced by development of tolerance in habitual users. The goal of this project is to examine whether caffeine's elevation of blood pressure (BP) and cortisol (CORT) is smaller following regular intake. Understanding this reduction of effect is essential to properly evaluate caffeine's physiological effects and potential consequences for health. In view of public concerns about caffeine use and reports of negative health consequences, it is important to have a well established body of information about caffeine's effects and their modification by tolerance in humans. Tolerance will be tested by varying levels of intake from 0 to 600 mg/day (equivalent to 6 cups of coffee) in 128 volunteers over 4 weeks and examining the resulting modifications of blood pressure and cortisol responses to an acute caffeine dose (3.3 mg/kg). Caffeine's ability to elevate BP and CORT represents two of its most pervasive and important physiological effects, and these will be the model response systems under study. This project has three specific aims: first to study the effect of tolerance on acute (1 hr) BP and CORT responses to a morning challenge dose of caffeine; second to measure the effect of tolerance on BP and CORT responses during acute stress (30 min mental stress or exercise) following the morning challenge dose; and third to examine the effect of tolerance on levels of BP and CORT during a day of ambulatory BP monitoring following a repeated challenge dose. The primary hypothesis is that regular intake of caffeine produces a partial tolerance to its effects, and that this may vary substantially from person to person. This information will help us to properly evaluate in context the evidence showing that caffeine can alter physiological functions and responses to stress.

描述：这项工作的目的是建立 有关咖啡因对心血管和心血管的影响的信息 休息期间以及心理和运动期间的神经内分泌功能 压力源。咖啡因广泛用于药理学意义 数量。它影响中枢神经系统，心血管 活性和神经内分泌功能。消费可能会增加 精神压力的时代，并且经常在运动过程中存在。 咖啡因已被证明会增加心血管疾病危险因素 例如血清胆固醇和脂质级分。但是，潜力 咖啡因的影响可能会因耐受性的发展而降低 习惯用户。 该项目的目的是检查咖啡因的海拔 常规后血压（BP）和皮质醇（Cort）较小 进气。了解这种降低的效果对于正确的效果至关重要 评估咖啡因的生理影响和潜在的后果 健康。鉴于公众对咖啡因使用的关注以及 负面的健康后果，重要的是要建立良好 有关咖啡因作用的信息及其修饰 人类的宽容。公差将通过不同的水平进行测试 128 志愿者超过4周，并检查了由此产生的修改 血压和皮质醇对急性咖啡因剂量的反应（3.3 mg/kg）。咖啡因提升BP和Cort的能力代表其中两个 最普遍和重要的生理影响，这些将是 正在研究的模型响应系统。 该项目具有三个具体的目标：首先研究 对急性（1小时）BP的公差和对早晨挑战的Cort反应 咖啡因剂量；其次衡量公差对BP和BP的影响 急性应激期间的cort反应（30分钟的精神压力或运动） 紧随早晨的挑战剂量；第三来检查 在卧床BP的一天中，BP和Cort水平的容忍度 重复挑战剂量后监视。主要假设 是定期摄入咖啡因会产生部分耐受性 效果，这可能因人而异。 这些信息将帮助我们在上下文中正确评估 证据表明咖啡因可以改变生理功能和 对压力的反应。