CAFFEINE INFLUENCES ON EXERCISE AND PSYCHOLOGICAL STRESS

咖啡因对运动和心理压力的影响

• 批准号: 2216943
• 负责人: William R Lovallo
• 金额: $ 33.9万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2216943
• 关键词: blood pressure; caffeine; cardiovascular function; cardiovascular stress test; cortisol; dosage; drug tolerance; echocardiography; exercise; human subject; neuroendocrine system; physiologic stressor; psychological stressor; psychomotor function; psychopharmacology; stress

DESCRIPTION: The objective of this work is to develop a base of information about the effects of caffeine on cardiovascular and neuroendocrine functions during rest and during mental and exercise stressors. Caffeine is widely used in pharmacologically significant quantities. It affects the central nervous system, cardiovascular activity, and neuroendocrine function. Consumption may increase during times of mental stress, and it is often present during exercise. Caffeine has been shown to increase cardiovascular disease risk factors such as serum cholesterol and lipid fractions. However, the potential effects of caffeine may be reduced by development of tolerance in habitual users. The goal of this project is to examine whether caffeine's elevation of blood pressure (BP) and cortisol (CORT) is smaller following regular intake. Understanding this reduction of effect is essential to properly evaluate caffeine's physiological effects and potential consequences for health. In view of public concerns about caffeine use and reports of negative health consequences, it is important to have a well established body of information about caffeine's effects and their modification by tolerance in humans. Tolerance will be tested by varying levels of intake from 0 to 600 mg/day (equivalent to 6 cups of coffee) in 128 volunteers over 4 weeks and examining the resulting modifications of blood pressure and cortisol responses to an acute caffeine dose (3.3 mg/kg). Caffeine's ability to elevate BP and CORT represents two of its most pervasive and important physiological effects, and these will be the model response systems under study. This project has three specific aims: first to study the effect of tolerance on acute (1 hr) BP and CORT responses to a morning challenge dose of caffeine; second to measure the effect of tolerance on BP and CORT responses during acute stress (30 min mental stress or exercise) following the morning challenge dose; and third to examine the effect of tolerance on levels of BP and CORT during a day of ambulatory BP monitoring following a repeated challenge dose. The primary hypothesis is that regular intake of caffeine produces a partial tolerance to its effects, and that this may vary substantially from person to person. This information will help us to properly evaluate in context the evidence showing that caffeine can alter physiological functions and responses to stress.

描述：这项工作的目的是开发一个基础 有关咖啡因对心血管的影响的信息 休息、精神和运动期间的神经内分泌功能 压力源。咖啡因广泛应用于具有重要药理作用的领域 数量。它影响中枢神经系统、心血管系统 活动和神经内分泌功能。期间消费可能会增加 精神紧张的时候，运动时经常出现。 咖啡因已被证明会增加心血管疾病的危险因素 例如血清胆固醇和脂质成分。然而，潜力 咖啡因的影响可能会因耐受性的发展而减弱 习惯用户。 该项目的目标是检查咖啡因是否会升高 常规治疗后血压 (BP) 和皮质醇 (CORT) 较小 摄入量。了解这种影响的减少对于正确地 评估咖啡因的生理效应和潜在后果 健康。鉴于公众对咖啡因使用的担忧和报告 负面的健康后果，重要的是建立一个完善的 有关咖啡因的作用及其修饰的信息体 人类的耐受性。耐受性将通过不同水平的测试 128 每日摄入量为 0 至 600 毫克（相当于 6 杯咖啡） 志愿者在 4 周内检查了由此产生的修改 血压和皮质醇对急性咖啡因剂量的反应（3.3 毫克/千克）。咖啡因升高血压和 CORT 的能力代表了它的两个特点 最普遍和最重要的生理效应，这些将是 正在研究的模型响应系统。 该项目有三个具体目标：首先研究 对早晨挑战的急性（1小时）BP和CORT反应的耐受性 咖啡因剂量；其次测量耐受性对血压的影响 急性压力期间的 CORT 反应（30 分钟精神压力或运动） 早晨注射激发剂量后；第三，检查效果 一天动态血压期间血压和 CORT 水平的耐受性 重复激发剂量后进行监测。主要假设 经常摄入咖啡因会产生部分耐受性 影响，并且这可能因人而异。 这些信息将帮助我们在上下文中正确评估 有证据表明咖啡因可以改变生理功能 对压力的反应。