Pacific Northwest Center for Translational Environmental Health Research
西北太平洋转化环境健康研究中心
基本信息
- 批准号:10383759
- 负责人:
- 金额:$ 120.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:Access to InformationAddressAirAnatomyAnimal ExperimentsAreaBehavioralBig DataBiologicalBiological AssayBiomedical ResearchCategoriesCell Culture TechniquesChemical ExposureChemicalsCommerceCommunitiesCommunity HealthcareCore FacilityCountryDataData ScienceDevicesDietDiseaseDrug CostsDrug TargetingEnvironmental HealthEventExhibitsExposure toFlame RetardantsGene ExpressionGoalsHazardous ChemicalsHealthHealth PersonnelHealth SciencesHomeHumanHuman BiologyIndividualIndustryInstitutionInterdisciplinary StudyInternationalKnowledgeLaboratoriesLeadLearningMammalsManufacturer NameMeasurableMethodsModelingMotor ActivityNational Institute of Environmental Health SciencesNatureNoiseNonprofit OrganizationsOregonOrganOrganismOutcomePacific NorthwestPathway interactionsPersonsPesticidesPharmacologic SubstancePhenotypePhysiologyPoisonPopulationPositioning AttributePredispositionPublic HealthReproducibilityResearchResearch PersonnelResearch Project GrantsRobotRunningSafetySamplingScientistServicesSignal TransductionSoilSpecific qualifier valueStrategic PlanningStructureTechniquesTechnologyToxic Environmental SubstancesToxic effectToxicologyToxinTranslational ResearchTranslationsUniversitiesWaterWorkplaceZebrafishadverse outcomebasebiological researchcommunity engagementcostdata to knowledgedecision researchdrug developmentdrug discoveryevidence baseexperienceexperimental studygerm free conditiongood laboratory practicehazardhealth literacyhuman tissueimprovedinsightinterestmembermicrobiomemultidisciplinaryphthalatesremediationresponseskillssuccesstooltranscriptomicsvolatile organic compoundwhole genome
项目摘要
OVERALL SUMMARY
A dominant paradigm of environmental health science is the adverse outcome pathway. The adverse outcome
pathway contains an external segment and an internal segment. The external segment is a toxic chemical that
comes into contact with a person. That chemical may come from air, water, soil, or diet. The internal segment
of the outcome pathway consists of a chain of events: the chemical interacts with a biological target, which
triggers events that in turn lead to organ responses, organism responses, and population responses. This
framework supports the most important environmental health science questions of our era: What chemical
exposures cause disease? How do they cause disease? Why are some people more susceptible than others? How
can we predict toxicity? How can we mitigate the impacts of hazardous chemicals? How can we reduce the use
of toxic chemicals in commerce? To answer these questions, the OSU EHS CC has an established world-leading
position in two of the world's most powerful technologies for investigating the adverse outcome pathway. To
study the external segment, the Chemical Exposure (CXC) Facility Core has developed passive sampling
wristbands that capture volatile and semi-volatile organic chemicals, as well as analytical techniques that can
detect and quantify 1,500 compounds in a single run at low cost. To study the internal segment, the Zebrafish
Biomedical Research (ZBR) Facility Core has built the world's largest specific-pathogen-free (i.e., low-
experimental-noise) zebrafish environmental health sciences facility. Robots evaluate locomotor activity and
look for physical and behavioral endpoints. Full-genome transcriptomics analyses reveal which gene
expressions change before the phenotype changes. Together, the CXC and the ZBR give our investigators
uniquely powerful experimental capabilities in EHS. Furthermore, these technologies are more than
complementary; they are synergistic. We have applied wristband extracts as direct input to the zebrafish
bioassay and identified the most toxic compounds in chemical mixtures via effects-directed analysis. Our
Integrated Health Sciences Facilities and Community Engagement Cores will make these capabilities available
to the extended EHS community via a new translational research model. We plan to co-produce knowledge
with stakeholders in seven categories (residential communities, legislators, regulators, manufacturers, health
care providers, pharmaceutical firms, and non-profit organizations). EHS CC members will conduct cross-
sectoral multidisciplinary research with these stakeholders in order to generate actionable scientific evidence to
guide stakeholder decisions that will improve environmental public health.
总体总结
环境健康科学的一个主导范式是不良结果途径。不良结果
通路包含外部段和内部段。外部部分是一种有毒化学物质,
与一个人接触。这种化学物质可能来自空气、水、土壤或饮食。内部部分
结果途径由一系列事件组成:化学物质与生物靶标相互作用,
触发事件,进而导致器官反应、有机体反应和群体反应。这
框架支持我们这个时代最重要的环境健康科学问题:什么化学物质
接触会导致疾病吗?它们是如何引起疾病的?为什么有些人比其他人更容易受到影响?如何
我们可以预测毒性吗?如何减轻危险化学品的影响?怎样才能减少使用
商业中的有毒化学品?为了回答这些问题,OSU EHS CC 建立了世界领先的
在世界上最强大的两项研究不良结果途径的技术中处于领先地位。到
研究外部部分,化学暴露 (CXC) 设施核心开发了被动采样
捕获挥发性和半挥发性有机化学物质的腕带,以及可以
单次运行即可以低成本检测和定量 1,500 种化合物。为了研究斑马鱼的内节
生物医学研究 (ZBR) 核心设施已建成世界上最大的无特定病原体(即低
实验噪声)斑马鱼环境健康科学设施。机器人评估运动活动并
寻找身体和行为终点。全基因组转录组学分析揭示了哪个基因
表达在表型改变之前发生改变。 CXC 和 ZBR 共同为我们的调查人员提供
EHS方面独特的强大实验能力。此外,这些技术不仅
补充;它们是协同作用的。我们将腕带提取物作为斑马鱼的直接输入
生物测定并通过效应导向分析识别化学混合物中毒性最强的化合物。我们的
综合健康科学设施和社区参与核心将使这些功能可用
通过新的转化研究模型向扩展的 EHS 社区提供帮助。我们计划共同生产知识
与七类利益相关者(居住社区、立法者、监管者、制造商、卫生部门)
护理提供者、制药公司和非营利组织)。 EHS CC 成员将进行跨
与这些利益相关者进行部门多学科研究,以产生可操作的科学证据
指导利益相关者做出改善环境公共卫生的决策。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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{{ truncateString('EMILY HO', 18)}}的其他基金
Pacific Northwest Center for Translational Environmental Health Research
西北太平洋转化环境健康研究中心
- 批准号:
10207636 - 财政年份:2020
- 资助金额:
$ 120.43万 - 项目类别:
Diet and arsenic interactions in the development of diabetes
饮食和砷在糖尿病发展中的相互作用
- 批准号:
8997082 - 财政年份:2015
- 资助金额:
$ 120.43万 - 项目类别:
Dietary histone deactylase inhibitors in prostate cancer prevention
膳食组蛋白脱乙酰酶抑制剂预防前列腺癌
- 批准号:
7908175 - 财政年份:2009
- 资助金额:
$ 120.43万 - 项目类别:
Dietary histone deactylase inhibitors in prostate cancer prevention
膳食组蛋白脱乙酰酶抑制剂预防前列腺癌
- 批准号:
7256593 - 财政年份:2007
- 资助金额:
$ 120.43万 - 项目类别:
Dietary histone deactylase inhibitors in prostate cancer prevention
膳食组蛋白脱乙酰酶抑制剂预防前列腺癌
- 批准号:
7777848 - 财政年份:2007
- 资助金额:
$ 120.43万 - 项目类别:
Dietary histone deactylase inhibitors in prostate cancer prevention
膳食组蛋白脱乙酰酶抑制剂预防前列腺癌
- 批准号:
7413331 - 财政年份:2007
- 资助金额:
$ 120.43万 - 项目类别:
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Pacific Northwest Center for Translational Environmental Health Research
西北太平洋转化环境健康研究中心
- 批准号:
10207636 - 财政年份:2020
- 资助金额:
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Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic research
整合生命历程方法、生物学和数字表型以支持心肺疾病流行病学研究
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