Perioperative Cognitive Anesthesia Network (PeCAN) Program for Alzheimer’s Disease and Related Dementias

针对阿尔茨海默病和相关痴呆症的围手术期认知麻醉网络 (PeCAN) 计划

基本信息

批准号：
10379966
负责人：
CATHERINE E PRICE
金额：
$ 16.2万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10379966
关键词：
Academic/Teacher Award Address Adult Advisory Committees Aging Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease patient Alzheimer&apos s disease related dementia Alzheimer’s disease biomarker Anesthesia procedures Anesthesiology Animal Experimentation Animals Awareness Biological Markers Blood - brain barrier anatomy Brain Capsicum Cardiac Caring Case Study Center for Translational Science Activities Clinical Clinical Sciences Clinical Services Cognition Cognitive Collaborations Colonoscopy Communities Data Science Core Data Sources Databases Delirium Dementia Development Diagnosis Disease Education Elderly Electroencephalography Face Florida Funding Grant Health Health system Healthcare Healthcare Systems Human Impaired cognition Individual Inflammation Infrastructure Institutes Institution Intervention Investigation Lead Leadership Medical Medicine Memory Mentorship Methods Nerve Degeneration Neurodegenerative Disorders Neurons Neuropsychology Operative Surgical Procedures Outcome Parkinson Disease Pathway interactions Patients Pecans Perioperative Perioperative Care Persons Population Postoperative Period Procedures Quality of life Records Replacement Arthroplasty Research Research Personnel Research Training Resources Retrospective Studies Risk Risk Factors Science Scientist Statistical Models Thick Time Training Training Programs Translational Research United States National Institutes of Health Universities Vascular Dementia Ventricular White Matter Disease brain behavior brain health certificate program clinical care cognitive change cognitive function cognitive reserve curriculum development deep learning evidence base human old age (65+)improved innovation longitudinal human study meetings mild cognitive impairment mortality multidisciplinary nervous system disorder neuroimaging neuroimaging marker non-demented novel older patient postoperative delirium pre-doctoral programs prospective recruit research study screening success symposium trend

项目摘要

ABSTRACT Our healthcare system faces larger numbers of individuals with early to late Alzheimer’s Disease (AD) and other neurodegenerative disorders requiring anesthesia associated procedures for serious health related conditions (e.g., cardiac), screening (e.g., colonoscopy), or quality of life improvement (e.g., joint replacement). Despite evidence that preoperative cognitive status is a risk factor for negative post-operative outcomes, there is a scarcity of research addressing perioperative cognitive-biomarker-anesthesia interactions, and evidence based anesthesia-surgical practices for patients with prodromal or diagnosed dementias. The K07 applicant- an NIH funded independent investigator and board certified neuropsychologist with expertise in the cognitive sequelae and associated neuroimaging markers of AD, vascular dementia, and other neurodegenerative disorders, and cognitive and neuroimaging predictors of perioperative cognitive complications and delirium. The applicant (with support of the institution) is proposing a Perioperative Cognitive Anesthesia Network (PeCAN) Program for AD and related dementia. The purpose– to promote institutional and community awareness of cognition and memory in older adults electing surgical procedures with anesthesia, intensify collaborations on AD biomarkers- anesthesia interactions, and promote translation of research findings to clinical care. The applicant will complete advanced leadership training and three programmatic aims. Aim 1- convene a multidisciplinary advisory team to establish four integrated PeCAN research cores targeting AD and related dementia perioperative research. Cores include a Cognitive-Clinical Core, a Neuroimaging Core, a Biomarker Core, and a Data Science Core. Aim 2- enhance defined and supportive pathways to the PeCAN cores so that early stage investigators can efficiently initiate and complete perioperative-neurodegenerative research. The applicant will integrate pathways between multiple institutional resources including NIH funded 1Florida Alzheimer’s Disease Research Center, Evelyn F. McKnight Brain Institute, the University of Florida (UF) Institute on Aging Pepper Center, and the UF Fixel Center for Neurological Diseases. Aim 3- promote the emergence of highly trained scientists and educators for innovative team science addressing perioperative neuronal risk and mechanisms for protection. Methods will involve implementation of a certificate program, interdisciplinary team-science research opportunities, and pilot funding supported through this grant and institutional matching funds. Trainees will initially include appropriate predoctoral T32 trainees, neuropsychology fellows, and anesthesiology fellows. Milestones- annual analyses of programmatic strengths/weaknesses, multidisciplinary proposal submissions, and evidence of trainee success with perioperative research for AD and related dementias.

抽象的我们的医疗保健系统面临着大量患有早期至晚期阿尔茨海默病 (AD) 和其他疾病的患者需要麻醉的神经退行性疾病与严重健康相关疾病相关的手术（例如心脏检查）、筛查（例如结肠镜检查）或生活质量改善（例如关节置换）。有证据表明术前认知状态是术后不良结果的危险因素，缺乏针对围手术期认知-生物标志物-麻醉相互作用的研究，并且基于证据针对前驱或确诊痴呆症患者的麻醉手术实践 K07 申请人 - NIH。资助独立调查员和经过认证的神经心理学家，具有认知后遗症方面的专业知识以及 AD、血管性痴呆和其他神经退行性疾病的相关神经影像标记物，以及围手术期认知并发症和谵妄的认知和神经影像预测因素（与。该机构的支持）正在提议针对 AD 实施围手术期认知麻醉网络 (PeCAN) 计划目的——提高机构和社区对认知和记忆的认识。在选择麻醉手术的老年人中，加强 AD 生物标志物方面的合作申请人将完成麻醉相互作用，并促进研究成果转化为临床护理。高级领导力培训和三个计划目标目标 1 - 召集多学科顾问团队建立四个针对 AD 和相关痴呆症围手术期研究的综合 PeCAN 研究核心。核心包括认知临床核心、神经影像核心、生物标记核心和数据科学核心。目标 2 - 增强 PeCAN 核心的明确和支持性途径，以便早期研究人员能够申请人将有效地启动和完成围手术期神经退行性研究。多个机构资源之间的合作，包括 NIH 资助的 1 佛罗里达阿尔茨海默病研究中心，伊芙琳·F·麦克奈特大脑研究所、佛罗里达大学 (UF) 老化胡椒研究所和佛罗里达大学 Fixel 神经疾病中心的目标 3 - 促进训练有素的科学家和教育工作者的出现。解决围手术期神经风险和保护机制的创新团队科学方法将。涉及证书计划的实施、跨学科团队科学研究机会以及试点通过这笔赠款和机构配套资金支持的资金最初将包括适当的资金。博士前 T32 实习生、神经心理学研究员和麻醉学研究员的里程碑 - 年度分析。计划的优势/劣势、提交的多学科提案以及实习生成功的证据 AD 和相关痴呆症的围手术期研究。