Development of a Quality of Life Decision-Making Model for Older Patients with Acute Myeloid Leukemia

老年急性髓系白血病患者生活质量决策模型的开发

• 批准号: 10379424
• 负责人: Sara Tinsley
• 金额: $ 15.79万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-04 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10379424
• 关键词: Acute Myelocytic Leukemia; Address; Adult Acute Myeloblastic Leukemia; Affect; Aftercare; Age; Age-Years; Bone Marrow; Cancer Center; Cancer Survivor; Caregivers; Caring; Characteristics; Clinical; Clinical Research; Cytogenetics; Decision Making; Dependence; Development; Diagnosis; Disease; Elderly; Family; Future; Goals; Individual; K-Series Research Career Programs; Knowledge; Learning; Life; Malignant Bone Neoplasm; Measurement; Measures; Modeling; Monitor; National Institute of Nursing Research; Newly Diagnosed; Nurses; Outcome; PF4 Gene; Palliative Care; Patient Preferences; Patients; Pilot Projects; Population; Predictive Factor; Probability; Process; Publications; Quality of life; Randomized Controlled Trials; Research; Research Design; Research Personnel; Risk; Site; Statistical Methods; Strategic Planning; Supportive care; Survival Rate; Symptoms; Testing; Therapeutic; Transfusion; United States National Institutes of Health; Work; aged; associated symptom; base; burden of illness; career; chemotherapy; common symptom; comorbidity; data management; design; end of life care; functional status; high risk; improved; individual patient; innovation; older patient; optimal treatments; patient population; physical symptom; preference; routine care; skills; symptomatic improvement; treatment as usual; treatment choice; trial comparing

Project Summary/Abstract Older patients (≥ 60 years of age) with acute myeloid leukemia (AML) do not have enough information, based on research, to determine the best chemotherapy treatment that aligns with their goals, whether for survival or improved quality of life (QOL). This proposal seeks to identify significant patient factors and disease characteristics in order to build a patient decision-making model focused on QOL, while monitoring survival. This will provide an aid to patients when choosing the most appropriate treatment that optimally aligns with their goals for care. This career development award constructs a patient QOL decision-making model integrating significant clinical disease and patient factor predictors in older patients diagnosed with AML at Moffitt Cancer Center. The Specific Aims of the research are to: 1) Describe differences in QOL among newly diagnosed older AML patients receiving intensive versus non-intensive chemotherapy (at baseline and 30, 60, 90 and 180 days post treatment); 2) Identify the individual clinical disease characteristics (blast percentage, transfusion dependence, and cytogenetic risk group), and patient factors (age, comorbidities, functional status, and physical symptoms) of newly diagnosed older AML patients that predict their QOL among those receiving two treatments, intensive versus non-intensive chemotherapy; 3) Design a patient decision making model integrating significant clinical disease and patient factor predictors of QOL for newly diagnosed older AML patients receiving intensive versus non-intensive treatment. Probability will be provided to patients in pie charts for survival and total QOL score with treatment intensity. Proposed Career and Learning Objectives are to: 1) Develop expertise in palliative care, focused on the unique needs of individuals diagnosed with acute myeloid leukemia; 2) Attain skills and knowledge for the clinical research application of decision-making model research; 3) Attain advanced skills in study design, data management, measurement, and statistical methods to identify factors; 4) Disseminate findings through publications and presentations; 5) Develop grantsmanship skills. Long-term career goal: Randomized controlled trial comparing the alignment of treatment with preferences in older patients with AML with integration of the model into their care to usual care.

项目概要/摘要 患有急性髓系白血病 (AML) 的老年患者（≥ 60 岁）没有足够的信息， 根据研究，确定符合其目标的最佳化疗方案，无论是 为了生存或提高生活质量（QOL），该提案旨在确定重要的患者因素和 疾病特征，以建立关注 QOL 的患者决策模型，同时监测 这将为患者选择最合适的治疗方法提供帮助。 以及他们的护理目标。 该职业发展奖构建了一个整合重要临床信息的患者生活质量决策模型 莫菲特癌症中心诊断患有 AML 的老年患者的疾病和患者因素预测因子。 该研究的具体目标是： 1) 描述新诊断的老年 AML 的生活质量差异 接受强化化疗与非强化化疗的患者（基线和第 30、60、90 和 180 天） 2) 确定个体临床疾病特征（母细胞百分比、输血率） 依赖性和细胞遗传学风险组），以及患者因素（年龄、合并症、功能状态和 新诊断的老年 AML 患者的身体症状）可以预测接受两种治疗的患者的生活质量 治疗，强化化疗与非强化化疗；3) 设计患者决策模型 整合重要的临床疾病和患者生活质量预测因子，用于新诊断的老年 AML 接受强化治疗与非强化治疗的患者的概率将提供给饼中的患者。 生存率和总生活质量评分与治疗强度的图表。 建议的职业和学习目标是： 1) 发展姑息治疗方面的专业知识，重点关注 被诊断患有急性髓性白血病的个体的独特需求； 2) 获得相关技能和知识； 决策模型研究的临床研究应用；3) 获得研究设计、数据方面的高级技能； 确定因素的管理、测量和统计方法； 4) 通过以下方式传播调查结果； 出版物和演讲；5) 培养资助技能。 长期职业目标：随机对照试验比较治疗与偏好的一致性 患有 AML 的老年患者将该模型整合到他们的护理和常规护理中。

项目成果

An Integrative Review of Sex Differences in Quality of Life and Symptoms Among Survivors of Hematologic Malignancies.

血液系统恶性肿瘤幸存者生活质量和症状性别差异的综合评价。

• 发表时间: 2023-04-21
• 影响因子: 1.9
• 作者: Tinsley;Durosier Mertilus, Dorothie S;Nodzon, Lisa;Lengacher, Cecile A
• 通讯作者: Lengacher, Cecile A

Treatment Choices: A Quality of Life Comparison in Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome.

治疗选择：急性髓系白血病和高危骨髓增生异常综合征的生活质量比较。

• 发表时间: 2017
• 作者: Tinsley, Sara M;Sutton, Steven K;Thapa, Ram;Lancet, Jeffrey;McMillan, Susan C
• 通讯作者: McMillan, Susan C

Sex Disparities in Myelodysplastic Syndromes: Genotype, Phenotype, and Outcomes.

骨髓增生异常综合征的性别差异：基因型、表型和结果。

• DOI: 10.1016/j.clml.2023.01.007
• 发表时间: 2023-01-01
• 期刊: Clinical lymphoma, myeloma & leukemia
• 作者: Sara M. Tinsley;N. A. Ali;S. Ball;L. Aguirre;A. Jain;M. Hussaini;O. Chan;A. Kuykendall;K. Sweet;J. Lancet;E. Padron;D. Sallman;R. Komrokji
• 通讯作者: R. Komrokji