MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES

慢性病遗传流行病学模型

• 批准号: 2197458
• 负责人: SANDRA J HASSTEDT
• 金额: $ 5.62万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2197458
• 关键词: alleles; chronic disease /disorder; computer data analysis; developmental genetics; epidemiology; genetic disorder; genetic mapping; genetic markers; genetic models; genotype; human age group; human data; human population genetics; mathematical model; model design /development; pleiotropism; sex linked trait

Many common diseases, although familial, appear not to follow simple modes of inheritance. In some cases the inheritance may be simple, but nongenetic factors affect the phenotypes, thereby obscuring the genetic pattern. For example, environmental factors which affect the phenotype may aggregate in families, resulting in nongenetic familiality. Pleiotropic genes may produce inconsistent effects on multiple phenotypes. Assortative mating may produce more offspring resembling their parents than expected assuming random mating. Phenotypic expression may require an environmental stimulus, resulting in reduced penetrance in its absence. Aging may promote expression of the phenotype, mimicking reduced genetic transmission to offspring. The expression of the same genotype may differ between males and females. Unless the analyses of such phenotypes assume models which include these nongenetic factors, the genetic effect may be undetectable or falsely inferred. This application proposes to develop, implement, and apply genetic models used to detect major genes in the presence of nongenetic factors. The implementation will occur in PAP, a Fortran program for likelihood analysis. The extensions proposed include regressive models for univariate and multivariate phenotypes, age of onset curves, and unequal variances across PAP for other users will be continued.

许多常见疾病虽然家族性，但似乎不遵循简单的模式 继承。 在某些情况下，继承可能很简单，但是 非核因子影响表型，从而掩盖了遗传 图案。 例如，影响表型的环境因素可能 家庭的总体总体，导致非统家族性。 多效性 基因可能会对多种表型产生不一致的影响。 分类 交配可能产生的后代比预期 假设随机交配。 表型表达可能需要环境 刺激，导致其缺乏的渗透率降低。 衰老可能 促进表型的表达，模仿减少的遗传传播 向后代。 男性之间相同基因型的表达可能有所不同 和女性。 除非对此类表型的分析假设模型 包括这些非遗传因素，遗传效应可能是无法检测的，或者 错误地推断。 该申请建议开发，实施和应用遗传模型 用于在存在非核因子的情况下检测主要基因。 这 实施将发生在PAP，这是一个可能性的福特计划 分析。 建议的扩展名包括单变量的回归模型 和多元表型，发作曲线的年龄和不平等差异 在其他用户的PAP中将继续进行。