Rationale for the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) at Children?s National

国家儿童医院儿科血液学和输血医学多学科研究培训奖 (PHTMMRT) 的理由

• 批准号: 10360585
• 负责人: Catherine M. Bollard
• 金额: $ 12.39万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360585
• 关键词: Award; Child; Interdisciplinary Study; Pediatric Hematology; Research Training; transfusion medicine

The rationale for this renewal application is to continue our highly collaborative and multidisciplinary, inter- institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology. Our objective is to address the barriers for the conduct of high quality and transformative research in pediatric transfusion medicine and hematology including: 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators. This program is focused on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion, cell therapy and transplantation. The design of the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) is focused on preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program completes a Master's in Clinical and Translational Science (MsCTR) at the George Washington University (GWU) School of Medicine and Health Sciences or equivalent, and will devise, implement and complete a research project under the joint oversight of a multidisciplinary mentorship team. At the completion of the two- to three-year program, each trainee will have presented his/her data to at least one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and for those in a three-year program, submitted an external grant application to the NIH or equivalent funding source. The program is overseen by two NIH-funded Principal Investigators with complementary clinical and research expertise, supported by nine faculty of Children's National and GWU, with four external mentors. All mentors are research scientists with expertise in coagulation, transfusion medicine, cell therapy, transplantation, vascular biology and genomic/proteomics. A Diversity Enhancement Officer will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee of four NIH-funded national leaders in transfusion medicine, transplantation and hematology with established career mentorship programs will offer annual feedback and guidance of the PHTMMRT program and the trainees' progress. The PHTMMRT program will leverage several of Children's National's multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, GWU and Howard University School of Medicine (HUSM). In summary, our multidisciplinary, inter-institutional mentors will train four to five future academic leaders in Pediatric Hematology/Transfusion Medicine including a focus on cell-based therapies for heart, lung and blood diseases.

此次续签申请的理由是继续我们的高度协作和多学科、跨领域合作。 为儿科输血医学和血液学领域的未来科学家提供指导培训的机构计划。 我们的目标是消除儿科领域进行高质量和变革性研究的障碍 输血医学和血液学包括：1）缺乏强大的研究培训基础设施和 执行; 2）缺乏担任研究导师的中高级研究人员； 3）需要 多学科转化方法来回答关键的临床问题； 4）临床缺乏多样性 和转化研究者。该计划的重点是推进临床和转化奖学金 血液学、心血管和肺部疾病、输血、 细胞治疗和移植。小儿血液学与输血医学科的设计 多学科研究培训奖（PHTMMRT）专注于培养来自不同领域的学员 学术领导和独立资助的研究生涯的背景。项目中的每位学员 在乔治华盛顿大学完成临床和转化科学硕士学位 (MsCTR) （GWU）医学与健康科学学院或同等机构，并将设计、实施和完成 在多学科导师团队的联合监督下进行的研究项目。完成两件事后—— 在三年计划中，每位学员将向至少一次全国研究会议展示他/她的数据， 起草并提交了一份或多份适合外部同行评审出版物的手稿，以及 在一项为期三年的计划中，向 NIH 或同等资金来源提交了外部资助申请。这 该计划由两名 NIH 资助的首席研究员监督，具有互补的临床和研究 专业知识，由国家儿童医院和乔治华盛顿大学的九名教师以及四名外部导师的支持。所有导师 是在凝血、输血医学、细胞治疗、移植、 血管生物学和基因组/蛋白质组学。多元化增强官员将协助招聘 少数族裔、残疾人或弱势申请人以及妇女。最后，由四人组成的外部咨询委员会 美国国立卫生研究院 (NIH) 资助的输血医学、移植和血液学领域的国家领导人，拥有成熟的职业生涯 导师计划将提供 PHTMMRT 计划和学员的年度反馈和指导 进步。 PHTMMRT 计划将利用国家儿童基金会的多个和已有的项目 与 NIH、GWU 和霍华德大学等邻近研究机构的合作优势 医学院（HUSM）。总之，我们的多学科、跨机构导师将培训四到五名 儿科血液学/输血医学的未来学术领导者，包括关注基于细胞的 治疗心脏、肺和血液疾病。