DESCRIPTION AND PREDICTION OF HUMAN GROWTH IN STATURE

人类身高增长的描述和预测

• 批准号: 2199834
• 负责人: R DARRELL BOCK
• 金额: $ 9.88万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2199834
• 关键词: adolescence (12-20); analytical method; body height; body physical characteristic; child physical development; computer program /software; family genetics; hormone therapy; human data; infant human (0-1 year); longitudinal human study; mathematical model; middle childhood (6-11); model design /development; pituitary dwarfism; precocious puberty; preschool child (1-5); statistics /biometry; adolescence (12-20); analytical method; body height; body physical characteristic; child physical development; computer program /software; family genetics; hormone therapy; human data; infant human (0-1 year); longitudinal human study; mathematical model; middle childhood (6-11); model design /development; pituitary dwarfism; precocious puberty; preschool child (1-5); statistics /biometry

The project will investigate and perfect analytical tools for the description and prediction of growth in children. These procedures, which have been successfully tested in prototype, describe serial measurements over all or part of the growth cycle in terms of a compact model well suited to the study of genetic and environmental determinants of development. They also support an accurate and flexible system for the clinical evaluation of current growth status and the prediction of future growth as part of the preparation for the treatment of developmental disorders. The project will complement this structural approach to the analysis of serial measurements with a nonstructural description of more detailed variation within the main phases of growth in early, middle and late childhood. Our preliminary studies by this method already indicate the presence of "miniphases" of growth acceleration and deceleration during the years from four to adolescence. Further study, using the growth records for parent and offspring in two- and three-generation families available in the database of the Fels Longitudinal Study, will enable us to evaluate indications that these short-range growth phases have a heritable basis. The analytical tools developed in the project will be implemented in computerized form suitable for research and clinical use. They will include a procedure adapted to monitoring changes in the velocity and extent of growth during and following treatment interventions.

该项目将调查和完美的分析工具 描述和预测儿童的成长。 这些程序，这些程序 已在原型中成功测试，描述串行测量 在紧凑的模型方面，整个或部分生长周期的一部分 适合研究遗传和环境决定因素 发展。他们还支持一个准确，灵活的系统 当前增长状况和未来预测的临床评估 增长作为用于治疗发展的准备的一部分 疾病。 该项目将补充这种结构性方法以分析 串行测量，具有更详细的非结构描述 早期，中期和晚期增长的主要阶段的变化 童年。我们通过这种方法的初步研究已经表明 存在生长加速度和减速的“微生物” 从四个到青春期的岁月。进一步研究，使用增长 父母和后代的记录 在Fels纵向研究的数据库中可用，将使我们能够 评估这些短期生长阶段的迹象 可遗传的基础。 项目中开发的分析工具将在 计算机化形式适合研究和临床使用。 他们会的 包括一个适合监视速度变化的程序和 治疗干预期间和之后的生长程度。