MOLECULAR EPIDEMIOLOGY OF ONCHOCERCIASIS IN NIGERIA

尼日利亚盘尾丝虫病的分子流行病学

基本信息

批准号：
2004526
负责人：
THOMAS R UNNASCH
金额：
$ 11.63万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-23 至 1998-09-22
项目状态：
已结题

项目摘要

Onchocerciasis, or river blindness, is one of the most common causes of blindness worldwide. It is endemic throughout most of Sub-Saharan Africa, and is also found at several isolated foci in Central and South America. Through the efforts of the Onchocerciasis Control Programme, or OCP, onchocerciasis is no longer a significant public health problem throughout much of West Africa. Unfortunately, Nigeria has not been involved in the OCP, and Nigeria Is now the single most important focus of onchocerciasis worldwide. In the past several years, ivermectin has been shown to be a safe and effective treatment for onchocerciasis. One recent result of the discover of the effectiveness of ivermectin has been the development of several programs whose goal is to control onchocerciasis in Nigeria, by the distribution of ivermectin. The overall goal of this project is to use recently developed DNA probe technologies to detect O. volvulus to pro-Ttde epidemiological information that will be of use in most efficiently allocating the resources of ivermectin based onchocerciasis control programs in Nigeria. The specific aims of this project are to: l. Develop a facility to be based in Ibadan, Nigeria that is capable of utilizing the PCR based DNA probe based assays on a large scale basis. 2. To map the distribution of severely blinding and mild strains of O. volvulus in Nigeria. 3. To utilize recently developed PER based mass screening methods which detect O. volvulus infective larvae in vector black flies to assess the effect of long term ivermectin distribution on the transmission of severe O. volvulus in West Africa.

Onchocerciasis或河流失明是最常见的原因之一全球盲目。这是撒哈拉以下大部分地区的地方性非洲，也发现了中部和南部的几个孤立灶美国。通过OnChoceriasis控制计划的努力或 OCP，Onchocerciasis不再是一个重大的公共卫生问题整个西非大部分地区。不幸的是，尼日利亚还没有参与OCP，尼日利亚现在是最重要的重点全世界的杂虫病。在过去的几年中，伊维菌素有被证明是对尾尾c的安全有效的治疗方法。一发现伊维菌素有效性的最新结果一直是几个计划的制定，其目标是控制尼日利亚的尾尾c，通过伊维菌素的分布。这该项目的总体目标是使用最近开发的DNA探针检测O. volvulus至Pro-TTDE流行病学的技术最有效地分配的信息伊维菌素的资源基于尾尾co虫的控制程序尼日利亚。该项目的具体目的是：l。开发设施位于尼日利亚的伊巴丹，能够利用PCR 基于大规模的基于DNA探针的测定。 2。映射在严重盲目的O. volvulus中分布尼日利亚。 3。要利用最近开发的每个基于质量筛查检测O. volvulus感染性幼虫在载体黑蝇中的方法评估长期伊维菌素分布对西非严重的O. volvulus的传播。