Delaware Center for Musculoskeletal Research – Administrative Core

特拉华州肌肉骨骼研究中心 — 行政核心

• 批准号: 10352302
• 负责人: DAWN M ELLIOTT
• 金额: $ 102.31万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10352302
• 关键词: Advisory Committees; Annual Reports; Attention; Basic Science; Biological; Clinical Research; Collaborations; Communities; Complement; Complex; Cues; Data; Delaware; Development; Development Plans; Disease; Ensure; Evaluation; Extramural Activities; Faculty; Functional disorder; Funding; Future; Goals; Grant; Growth; Health; Infrastructure; Institutes; Leadership; Mentors; Musculoskeletal; Musculoskeletal Diseases; Office of Administrative Management; Periodicity; Program Development; Program Evaluation; Reporting; Research; Research Personnel; Research Project Grants; Resources; Structure; Therapeutic Intervention; Tissues; United States National Institutes of Health; Universities; Work; career development; formative assessment; improved; meetings; novel; operation; pre-clinical; pre-clinical research; programs; recruit; success; tool

PROJECT SUMMARY / ABSTRACT The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health and disorders, from the level of the entire body to the molecule, with an emphasis on the mechanisms by which physical and biological cues influence tissue structure and normal function, dysfunction, and potential therapeutic interventions. A strong Administrative Core will maximize the impact of the DCMR by successfully leading the administrative and fiscal operation of the Center and by supporting complex scientific operations that are interwoven within the Center and draw on resources available through various centers across the University of Delaware and beyond (Aim 1). Excellence and career development of the Project Leaders is critical to the success of the Center, as they conduct impactful musculoskeletal research within the Center and as future independent investigators. Thus, the Administrative Core will also implement a comprehensive mentoring and career development plan for Project Leaders that complements formal departmental mentoring and will enable them to launch successful research programs and attain independent investigator status (Aim 2). The Administrative Core will also work to expand the impact of the DCMR through establishing a collaborative interdisciplinary community, supporting a Pilot grant program, hiring new faculty, and retaining faculty (Aim 3). Finally, the Core will establish a rigorous evaluation program to assess progress toward Center milestones, using best practices in program evaluation and led by an expert internal evaluator (Aim 4). Added to the input of internal and external advisory committees, evaluation data will be used to continuously improve the Center and ensure that it is achieving its overarching goal: to accelerate fundamental and preclinical musculoskeletal research and contribute to a comprehensive basic-to-clinical research pipeline that will substantially reduce the burden of musculoskeletal disorders.

项目概要/摘要 特拉华州肌肉骨骼研究中心 (DCMR) 将支持基础和临床前研究 肌肉骨骼健康和疾病的中心主题，从整个身体的水平到分子， 强调物理和生物线索影响组织结构和正常的机制 功能、功能障碍和潜在的治疗干预措施。强大的行政核心将最大限度地发挥 通过成功领导该中心的行政和财政运作以及通过 支持中心内相互交织的复杂科学行动并利用可用资源 通过特拉华大学及其他地区的各个中心（目标 1）。卓越与事业 项目负责人的发展对于中心的成功至关重要，因为他们开展有影响力的工作 中心内的肌肉骨骼研究并作为未来的独立研究人员。因此，行政 Core 还将为项目负责人实施全面的指导和职业发展计划， 补充正式的部门指导，并使他们能够启动成功的研究计划和 获得独立调查员身份（目标 2）。行政核心还将努力扩大影响 DCMR 通过建立跨学科协作社区、支持试点资助计划、 聘用新教师并留住教师（目标 3）。最后，核心将建立严格的评估计划 在专家的领导下，利用项目评估中的最佳实践来评估中心里程碑的进展 内部评估员（目标 4）。加上内部和外部咨询委员会的输入，评估数据将 用于不断改进该中心并确保其实现其总体目标：加速 基础和临床前肌肉骨骼研究，并为全面的基础到临床做出贡献 研究管道将大大减轻肌肉骨骼疾病的负担。