ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

加强 CALERIE 网络以推进衰老生物学

• 批准号: 10348707
• 负责人: KIM M. HUFFMAN
• 金额: $ 66.43万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10348707
• 关键词: Address; Age; Aging; Ancillary Study; Area; Biological; Biological Process; Biology of Aging; Caloric Restriction; Calories; Capsicum; Caring; Clinical Research; Collaborations; Complex; Coupled; Data; Databases; Development; Discipline; Drug Targeting; Eating; Educational workshop; Energy Intake; Ensure; Epigenetic Process; Fellowship; Fostering; Funding; Genetic; Grant; Growth; Health; Human; Infrastructure; Insecta; Intake; Intervention; Investigation; Knowledge; Long-Term Effects; Longevity; Maintenance; Mediator of activation protein; NCI Scholars Program; Organ; Organism; Persons; Pilot Projects; Process; Proteomics; Publications; Randomized; Randomized Controlled Trials; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Review Committee; Rodent; Sampling; System; Systems Biology; Tissues; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Yeasts; base; biobank; career development; complex data; data repository; design; dietary; experience; interdisciplinary collaboration; member; metabolomics; nonhuman primate; phenotypic data; programs; repository; response; secondary analysis; support network; transcriptomics; trial design; web site; working group

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY ABSTRACT: In direct response to PA-20-071, Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies), we propose to enhance and grow the CALERIE Research Network into a self- sustaining infra-structure of samples, data, and aging biology investigators. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) was a randomized controlled trial designed to assess the effects in humans of two years of sustained caloric restriction without enforced changes of dietary composition. The overall objective was to elucidate underlying biological mechanisms and mediators of primary and secondary human aging. The rigorous design and execution of the CALERIE intervention produced an invaluable resource, including comprehensive phenotypic data that are coupled to biological samples. To ensure continued use of these samples and data, we describe a plan to create a self-sustained CALERIE Network. Our aims are to advance aging research through enhanced 1) utilization, 2) development and interdisciplinary growth of the CALERIE Research Network. Utilization of CALERIE resources will be promoted and stewarded by a Steering Committee, an NIA Biobank representative, NIA-supported Networks and Centers, annual workshops and working groups. These efforts will ensure best use of remaining CALERIE samples as well as incorporation of new data into a complex multi-level database. CALERIE Network inter- disciplinary growth will be fostered by attracting new and junior aging biologists to pilot projects, career development activities, and a rich pipeline of integrative systems biology projects. By developing more investigators, projects, and disciplines, new data and samples will be generated and will perpetuate the aging biology scientific cycle. Thus, completion of these aims should yield a mature, sustainable infrastructure that maintains and oversees CALERIE samples and data, perpetuates CALERIE ancillary integrative investigations, and contributes to overall advancement of understanding of human aging biology.

加强 CALERIE 网络以推进衰老生物学 抽象的： 直接响应 PA-20-071，研究基础设施的高级阶段开发和利用 跨学科老龄化研究），我们建议加强和发展 CALERIE 研究网络，使其成为一个自我 维持样本、数据和衰老生物学研究人员的基础设施。综合评估 减少能量摄入的长期影响 (CALERIE) 是一项随机对照试验，旨在 评估两年持续热量限制而不强制改变饮食对人类的影响 作品。总体目标是阐明潜在的生物学机制和介质 原发性和继发性人类衰老。 CALERIE 干预措施的严格设计和执行 产生了宝贵的资源，包括与生物相结合的全面表型数据 样品。为了确保继续使用这些样本和数据，我们描述了一项创建自我维持的计划 卡勒瑞网络。我们的目标是通过加强 1) 利用、2) 开发来推进衰老研究 以及 CALERIE 研究网络的跨学科发展。 CALERIE 资源的利用将 由指导委员会、NIA 生物库代表、NIA 支持的网络推动和管理 中心、年度研讨会和工作组。这些努力将确保充分利用剩余的 CALERIE 样本以及将新数据合并到复杂的多级数据库中。 CALERIE网络间 通过吸引新的和初级的老年生物学家参与试点项目、职业生涯，将促进学科发展 开发活动以及丰富的综合系统生物学项目。通过开发更多 研究人员、项目和学科，将产生新的数据和样本，并使老化永久化 生物学科学周期。因此，完成这些目标应该会产生一个成熟的、可持续的基础设施， 维护和监督 CALERIE 样本和数据，使 CALERIE 辅助综合性永久化 研究，并有助于全面推进对人类衰老生物学的理解。