Therapeutic ultrasound for treatment of hypothyroidism

治疗性超声治疗甲状腺功能减退症

基本信息

批准号：
10349615
负责人：
Vesna Zderic
金额：
$ 8.08万
依托单位：
GEORGE WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10349615
关键词：
Adipocytes Adrenal Glands Affect Apoptotic Area Biological Assay Biological Sciences Biomedical Engineering Body Temperature Body Weight Breathing CASP3 gene Calcitonin Catecholamines Cattle Cell Survival Cell physiology Cells Chromaffin Cells Clinical Defect Deficiency Diseases Disease Dose Dyes Elderly Endocrine Endocrine Glands Endocrine System Diseases Endocrine system Endocrinologist Endocrinology Engineering Enzyme-Linked Immunosorbent Assay Event Exclusion Fluorescence Fluorescence Microscopy Generations Goals Heart Rate Hormonal Hormone replacement therapy Hormones Human Hydrogen Peroxide Hypothyroidism In Vitro Insulin Measures Medicine Menstrual cycle Metabolic Diseases Metabolic hormone Metabolism Methods Modeling Modification Molecular Non-Insulin-Dependent Diabetes Mellitus Organ Pancreas Pathology Pathway interactions Persons Pharmacology Physiological Population Process Publishing Research Research Personnel Rodent Role Safety Schools Structure of beta Cell of islet Structure of thyroid parafollicular cell Testing Therapeutic Therapeutic Effect Thyroid Gland Thyroid Hormones Thyrotropin-Releasing Hormone Thyroxine Time Tissues Triiodothyronine Trypan Blue Ultrasonic Therapy United States Universities Washington Woman Work adiponectin combat cytotoxic effectiveness evaluation effectiveness testing human old age (65+)improved in vitro Model in vivo interest medical schools men novel obese person older patient programs sodium ion therapeutic target treatment optimization ultrasound

项目摘要

Project Abstract The thyroid gland is a regulatory organ within the endocrine system vital to many essential processes including breathing and heart rate, metabolism and body weight, menstrual cycles, and body temperature. Hypothyroidism is a common disease especially among the elderly, affecting 5–20% of women and 3–8% of men, and is on the rise in the United States. Thyroid hormone replacement therapy is used for treatment of hypothyroidism but suffers from various problems with therapy optimization and dose adjustment. Our main goal is to determine whether ultrasound can serve as a non-invasive and non-pharmacological method for treatment of hypothyroidism. Here, we propose a novel exploratory study to determine if and how ultrasound may stimulate and control thyroid gland function such as synthesis and release of metabolic hormones triiodothyronine (T3) and thyroxine (T4) in a physiologically relevant context. Our previous and ongoing research work has shown that low intensity therapeutic ultrasound releases insulin from pancreatic beta cells and rodent pancreas at physiological levels without compromising cell viability. This finding opens the doors for possible use of ultrasound therapy in ameliorating secretory defects in other endocrine diseases. The long-term goal of our collaborative research program among Schools of Engineering, Biological Sciences and Medicine at The George Washington University is to develop a mechanistic understanding of the role of therapeutic ultrasound in enhancing release of hormones as a potential treatment of various endocrine diseases. The main objective of this proposal is to determine whether and in what way ultrasound may impact release of thyroid hormones in an in vitro rodent thyroid gland model. Specific Aim 1 of this research work will focus on determining the effectiveness and safety of ultrasound stimulation of the thyroid gland for release of metabolic hormones with the hypothesis that ultrasound treatment promotes release of endocrine thyroid hormones T3 and T3 with little or no other secretory products being released. Specific Aim 2 will focus on determination of mechanisms of ultrasound impact on release of thyroid metabolic hormones with the hypothesis that the mechanism of ultrasound action on the release of thyroid metabolic hormones T3 and T4 is related to the transport of sodium ions and generation of hydrogen peroxide. If shown successful, our proposed approach may open new strategies to combat various endocrine and metabolic diseases.

项目摘要甲状腺是内分泌系统内的一个调节器官，对许多基本过程至关重要，包括呼吸和心率、新陈代谢和体重、月经周期和体温。是一种常见病，特别是在老年人中，影响 5-20% 的女性和 3-8% 的男性，在美国，甲状腺激素替代疗法用于治疗甲状腺功能减退症。我们的主要目标是确定治疗优化和剂量调整方面的各种问题。超声是否可以作为一种非侵入性、非药物治疗方法在这里，我们提出了一项新的探索性研究，以确定超声是否以及如何可能影响甲状腺功能减退症。刺激和控制甲状腺功能，例如代谢激素的合成和释放我们之前和正在进行的生理相关背景下的三碘甲状腺原氨酸 (T3) 和甲状腺素 (T4)。研究工作表明，低强度治疗超声可以从胰腺β细胞中释放胰岛素这一发现为生理水平的啮齿动物胰腺的研究打开了大门。超声治疗可能用于改善其他内分泌疾病的长期分泌缺陷。我们工程学院、生物科学学院和医学院之间的合作研究计划的目标乔治华盛顿大学致力于对治疗的作用形成机制性的理解超声波在增强激素释放方面作为潜在治疗各种内分泌疾病的主要手段。该提案的目的是确定超声是否以及以何种方式影响甲状腺的释放这项研究工作的具体目标 1 将重点确定体外啮齿动物甲状腺模型中的激素。超声刺激甲状腺释放代谢激素的有效性和安全性超声治疗促进内分泌甲状腺激素 T3 和 T3 释放的假设或没有其他分泌产品被发布具体目标 2 将侧重于确定机制。超声对甲状腺代谢激素释放的影响，假设其机制超声对甲状腺代谢激素T3和T4释放的作用与钠的转运有关如果成功的话，我们提出的方法可能会开辟新的策略。对抗各种内分泌和代谢疾病。