The role of stroke risk factors in the prevalence of stroke symptoms among Hispanic/Latinx Adults

中风危险因素在西班牙裔/拉丁裔成年人中风症状患病率中的作用

• 批准号: 10345665
• 负责人: Monik Carmen Jimenez
• 金额: $ 8.95万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10345665
• 关键词: Acculturation; Address; Adult; Age; Atrial Fibrillation; Behavioral; Black race; Blindness; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Clinical; Clinical Data; Clinical Research; Cognitive; Communities; Cuban; Data; Diabetes Mellitus; Diagnosis; Dominican; Economics; Ethnic group; Exhibits; Funding; Future; Geographic Locations; Heterogeneity; Hispanic; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hypertension; Incidence; Individual; Intervention; Knowledge; Laboratories; Latina; Latinx; Latinx population; Mediating; Mediation; Mentored Research Scientist Development Award; Mexican; Modeling; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Neurologic; Not Hispanic or Latino; Numbness; Participant; Patient Self-Report; Pharmaceutical Preparations; Physicians; Population; Population Heterogeneity; Prevalence; Principal Investigator; Puerto Rican; Questionnaires; Recording of previous events; Reporting; Research; Research Personnel; Risk Factors; Role; Screening procedure; Sentinel; Severities; Severity of illness; Smoking; Socioeconomic Factors; Stroke; Structure; Telephone; United States National Institutes of Health; Vision; Work; aged; base; cohort; design; diabetes control; epidemiology study; experience; functional outcomes; geographic difference; health disparity; high risk; high risk population; hypertension control; innovation; instrument; migration; mortality; novel; post stroke; prospective; racial and ethnic; racial difference; screening; sex; social; social culture; social factors; social health determinants; socioeconomics; stroke incidence; stroke outcome; stroke risk; stroke symptom; tailored messaging

PROJECT SUMMARY/ABSTRACT Hispanic/Latinx adults exhibit a significantly greater incidence of total stroke, younger age at stroke mortality, and worse neurologic, cognitive, and functional outcomes post-stroke than Whites. Identifying Hispanic/Latinx adults at high risk of stroke is critical to eliminating racial/ethnic inequities in stroke and long-term stroke outcomes. The Questionnaire for Verifying Stroke-Free Status is as a novel and validated screening tool used to identify individuals at a high risk of incident stroke through the self-report of stroke symptoms (sudden onset of unilateral weakness, unilateral numbness, loss of vision, loss of half-vision, inability to understand, and inability to communicate). Endorsement of at least one stroke symptom is predictive of total stroke incidence irrespective of other stroke risk factors, based on data from clinical and epidemiologic studies. However, current research has focused exclusively on non-Hispanic Black and White adults. Due to variability in the prevalence of stroke risk factors and social determinants of health among Hispanic/Latinx adults compared to other racial/ethnic groups, the relationship between stroke risk factors and stroke symptoms among and between Hispanic/Latinx adults is uncertain. This innovative project will address the critical gaps in our knowledge of the relationship between stroke risk factors and stroke symptoms among Hispanic/Latinx adults by (1) assessing the association between hypertension, diabetes (severity and clinical control) and stroke symptoms and variability across heritage group and (2) determining the clinical, socio-economic and socio-cultural factors explaining differences in stroke symptoms across Hispanic/Latinx heritage groups. These aims will be accomplished by utilizing previously collected data on stroke symptoms among participants of Hispanic Community Health Study/Study of Latinos (HCHS/SOL) as an extension of the Principal Investigator's National Heart, Lung and Blood Institute (NHLBI) funded K01 award (HL124391). The HCHS/SOL is a prospective NIH-funded cohort of over 16,000 Hispanic/Latinx adults of heterogenous heritage from four geographic regions. This application will also contribute to the NHLBI's strategic objectives to address disparities in health by filling crucial gaps in our understanding of stroke risk among and between Hispanic/Latinx adults and by promoting biomedical workforce diversity through the support of the applicant, a Latina investigator, transitioning toward independence. These data will be used to inform future R01 applications to implement culturally tailored messaging and screening interventions to identify Hispanic/Latinx adults at high risk of stroke.

项目概要/摘要 西班牙裔/拉丁裔成年人的总中风发病率显着更高，中风死亡率更年轻， 中风后的神经、认知和功能结果比白人更差。识别西班牙裔/拉丁裔 中风高危成年人对于消除中风和长期中风中的种族/民族不平等至关重要 结果。 用于验证无中风状态的问卷是一种新颖且经过验证的筛查工具，用于识别 通过自我报告中风症状（突然发作的中风），处于中风高风险的个体 单侧无力、单侧麻木、视力丧失、半视力丧失、无法理解、无能力 进行沟通）。至少一种中风症状的认可可预测中风总发生率 根据临床和流行病学研究的数据，不考虑其他中风危险因素。然而， 目前的研究主要集中在非西班牙裔黑人和白人成年人。由于可变性 与西班牙裔/拉丁裔成年人相比，中风危险因素和健康社会决定因素的患病率 其他种族/民族群体中的中风危险因素与中风症状之间的关系 西班牙裔/拉丁裔成年人之间的情况尚不确定。 这个创新项目将解决我们对两者之间关系的认识中的关键差距 通过 (1) 评估西班牙裔/拉丁裔成年人中风危险因素和中风症状之间的关联 高血压、糖尿病（严重程度和临床控制）和中风症状之间的差异及其变异性 遗传组和（2）确定临床、社会经济和社会文化因素解释 西班牙裔/拉丁裔传统群体中风症状的差异。这些目标将通过以下方式实现 利用先前收集的西班牙社区健康参与者中风症状的数据 拉丁裔研究/研究 (HCHS/SOL) 作为首席研究员国家心、肺和 血液研究所 (NHLBI) 资助的 K01 奖 (HL124391)。 HCHS/SOL 是一个由 NIH 资助的前瞻性队列 来自四个地理区域的超过 16,000 名具有异质血统的西班牙裔/拉丁裔成年人。这个应用程序 还将为 NHLBI 的战略目标做出贡献，即通过填补关键的空白来解决健康方面的差异 我们对西班牙裔/拉丁裔成年人之间的中风风险理解存在差距，并通过促进 通过申请人（一名拉丁裔调查员）的支持，实现生物医学劳动力的多样性，过渡到 独立。这些数据将用于为未来的 R01 应用提供信息，以实施文化定制 信息传递和筛查干预措施，以识别中风高风险的西班牙裔/拉丁裔成年人。