Improving goals-of-care discussions for patients with chronic life-limiting illness and acute respiratory failure

改善慢性生命限制性疾病和急性呼吸衰竭患者的护理目标讨论

• 批准号: 10347636
• 负责人: Robert Ying-Fu Lee
• 金额: $ 18.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10347636
• 关键词: Acute respiratory failure; Admission activity; Adopted; Adoption; Area; Behavioral; Caring; Chronic; Chronic Disease; Clinical Investigator; Clinical Trials; Communication; Data; Decision Making; Discipline of Nursing; Documentation; Electronic Health Record; Environment; Environmental Risk Factor; Ethnic Origin; Etiology; Exclusion; Expectancy; Family; Foundations; Future; Goals; Guidelines; Health; Health system; Incidence; Intensive Care; Intervention; Interview; Lead; Life; Logistic Regressions; Measurement; Measures; Mechanical ventilation; Medicine; Mentors; Methods; Minority; Natural Language Processing; Observational Study; Outcome; Outpatients; Palliative Care; Patient Care; Patient-Focused Outcomes; Patients; Physicians; Population; Process; Prognosis; Public Health; Publishing; Race; Reporting; Research; Research Activity; Research Design; Research Methodology; Research Training; Scientist; Severity of illness; Structure; Surveys; Testing; Theoretical Domains framework; Time Factors; Training; Training Activity; Universities; Washington; Work; analytical method; base; behavior change; career; cohort; cost; design; disability; effectiveness implementation study; effectiveness implementation trial; experience; high risk; improved; improved outcome; medical schools; mortality risk; novel strategies; patient oriented research; preference; primary outcome; prognostic; randomized trial; secondary outcome; shared decision making; therapy design; usability

PROJECT SUMMARY/ABSTRACT Patients with chronic life-limiting illness who develop acute respiratory failure are at high risk of death and disability. Because some such patients would choose to forego life-sustaining treatments in certain conditions, it is important that ICU clinicians assess patients’ values, goals, and treatment preferences, and incorporate these findings into shared decision-making to provide goal-concordant care. Unfortunately, my preliminary data as well as qualitative studies of other hospitalized populations suggest that ICU clinicians often miss opportunities to assess or incorporate patients’ goals of care into decision-making. This may lead to the delivery of unwanted intensive care and life-sustaining treatments, which is harmful to both patients and families, and results in the delivery of high-cost, low-value care. The proposed research in this application will use multimethod and mixed-methods approaches to: (1) examine current implementation of goals-of-care discussions for patients with acute respiratory failure and chronic life- limiting illness; (2) identify potentially modifiable clinician behavioral determinants that underlie deficiencies in goals-of-care communication, and iteratively redesign an existing outpatient communication-priming intervention toward the goal of promoting high-quality goals-of-care discussions in the ICU; and, (3) conduct a pilot randomized trial of the redesigned communication-priming intervention to improve the occurrence and quality of documented goals-of-care discussions for patients with acute respiratory failure and chronic life- limiting illness. Through a combination of mentored research activities and formal research training, I will receive valuable research training in analytical methods to enhance the validity of studies that use “real-world” data, application of mixed-methods research to inform health intervention design, and clinical trials. The proposed research and training activities will prepare me for a career as an independent clinical investigator, and will form the foundation for a body of research designed to improve outcomes for patients with acute respiratory failure. These research and training activities will be facilitated by the academically rich research environments of the University of Washington Schools of Medicine, Nursing, and Public Health, as well as the Cambia Palliative Care Center of Excellence at UW Medicine.

项目概要/摘要 患有慢性生命限制性疾病的患者如果出现急性呼吸衰竭，死亡风险很高，并且 因为一些此类患者在某些情况下会选择放弃维持生命的治疗， ICU 患者评估患者的价值观、目标和治疗偏好非常重要，并将其纳入其中 不幸的是，这些发现有助于共同决策以提供目标一致的护理。 以及对其他住院人群的定性研究表明，ICU 患者经常会错过 评估患者的护理目标或将其纳入决策的机会这可能会导致 提供不需要的重症监护和维持生命的治疗，这对患者和患者都有害 家庭，并导致提供高成本、低价值的护理。 本申请中拟议的研究将使用多方法和混合方法来：（1）检查 目前针对急性呼吸衰竭和慢性生命患者的护理目标讨论的实施情况 限制疾病；（2）确定潜在的可改变的临床医生行为决定因素 护理目标沟通，并迭代地重新设计现有的门诊沟通启动 旨在促进 ICU 高质量护理目标讨论的干预措施；以及 (3) 开展 重新设计的沟通启动干预措施的随机试点试验，以改善发生率和 急性呼吸衰竭和慢性生命患者的记录护理目标讨论的质量 限制疾病。 通过指导研究活动和正式研究培训的结合，我将获得宝贵的 分析方法的研究培训，以提高使用“真实世界”数据、应用的研究的有效性 混合方法研究为健康干预设计和临床试验提供信息。 培训活动将使我为独立临床研究者的职业生涯做好准备，并将形成 旨在改善急性呼吸衰竭患者预后的研究机构的基础。 这些研究和培训活动将通过该中心丰富的学术研究环境得到促进。 华盛顿大学医学院、护理学院和公共卫生学院以及 Cambia Palliative 华盛顿大学医学卓越护理中心。