Visual Sciences Center of Biomedical Research Excellence

视觉科学生物医学卓越研究中心

• 批准号: 10334874
• 负责人: Visvanathan Ramamurthy
• 金额: $ 211.65万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-20 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10334874
• 关键词: Achievement; Address; Advisory Committees; Affect; Appalachian Region; Award; Behavior; Biochemistry; Biological; Biology; Biomedical Engineering; Brain; Centers of Research Excellence; Clinical; Collaborations; Communities; Complex; Core Facility; Coupled; Development; Disease; Effectiveness; Electroretinography; Ensure; Environment; Esthesia; Evaluation; Extramural Activities; Faculty; Faculty Recruitment; Feedback; Funding; Goals; Grant; Health; Health Sciences; Imaging technology; Incidence; Infrastructure; Institution; Investigation; Light; Mediating; Mentors; Microscope; Mind; Morphology; Motor; National Institute of General Medical Sciences; Network Infrastructure; Neurosciences; Ophthalmology; Opsin; Optical Coherence Tomography; Outcome; Patients; Pilot Projects; Population; Positioning Attribute; Prevention approach; Process; Program Effectiveness; Program Research Project Grants; Research; Research Infrastructure; Research Personnel; Research Support; Resolution; Rest; Retina; Retinal Ganglion Cells; Review Committee; Scientist; Sensory; Specific qualifier value; Strategic Planning; Structure; Synaptic Transmission; System; Talents; Technology; Time; Translating; Transmission Electron Microscopy; United States National Institutes of Health; Universities; Vesicle; Vision; Visual; Visual impairment; Visual system structure; West Virginia; Work; base; career; cell type; comorbidity; disability; effectiveness evaluation; formative assessment; instrumentation; interdisciplinary approach; meetings; member; multidisciplinary; novel strategies; professor; programs; recruit; response; senior faculty; single-molecule FRET; success; symposium; tenure track; tool; trafficking; vision science; visual information

PROJECT SUMMARY/ABSTRACT The overarching goal of the Visual Sciences CoBRE (VS-CoBRE) is to optimize infrastructure and mentoring to support a sustainable, multidisciplinary, and collaborative research environment at WVU around visual sciences. The establishment of the VS-CoBRE will strengthen the scientific community focused on understanding processes that are essential to visual health with the long-term goal of contributing to novel approaches for prevention and treatment of blinding diseases that disproportionately affect Appalachia's population. West Virginia has the 2nd highest rate of visual disability in the nation, and the incidence is projected to double by 2050. We will achieve our goals by completing the following aims: Aim1, Support Project Leaders (PLs) to achieve independent extramural funding; Aim 2, Promote the fundamental understanding of the visual system through optimizing relevant technical infrastructure; Aim 3, Promote a comprehensive, multidisciplinary approach to impactful visual sciences research; and Aim 4: Implement a rigorous strategy to evaluate the effectiveness of the VS-CoBRE towards promoting a robust center of excellence in visual sciences. With our existing strengths and research infrastructure network, coupled with the initiatives proposed in this VS-CoBRE, including mentoring of our four-promising junior PLs, we are well-positioned to achieve our goal. The creation of a center of excellence provides a venue for integrating efforts across the campus, including activities supported by NIGMS including the WV CTSI and other CoBREs, the clinical enterprise in the Department of Ophthalmology and Visual Sciences, and investigations led by basic biologists in the Departments of Biochemistry, Neuroscience, Biology, and the program in Biomedical Engineering. The VS-CoBRE will coalesce vision scientists around a common theme, enhance the intellectual environment, and cultivate cross collaborations. When the investigators proposed for support by this grant achieve independence by obtaining an R01-equivalent award, we will leverage the VS-CoBRE to recruit additional junior scientists whose work pertains to visual sciences. The core facilities and research infrastructure supported by the CoBRE will also allow our investigators to produce research results that will translate to patients, moving us toward our ultimate goal of reducing the burden of visual impairment and its comorbidities in the Appalachian region, throughout the nation, and worldwide.

项目概要/摘要 视觉科学 CoBRE (VS-CoBRE) 的总体目标是优化基础设施和指导 支持西弗吉尼亚大学围绕视觉科学建立可持续、多学科和协作的研究环境。 VS-CoBRE 的建立将加强科学界的重点理解 对视觉健康至关重要的过程，其长期目标是为视觉健康做出贡献的新方法 预防和治疗严重影响阿巴拉契亚人口的致盲疾病。西方 弗吉尼亚州的视力障碍发生率位居全国第二，预计到 2050 年，该地区的视力障碍发生率将翻一番。 我们将通过完成以下目标来实现我们的目标： 目标 1，支持项目负责人 (PL) 实现 独立的外部资助；目标 2，通过以下方式促进对视觉系统的基本理解 优化相关技术基础设施；目标 3，促进综合性、多学科方法 有影响力的视觉科学研究；目标 4：实施严格的策略来评估 VS-CoBRE 旨在促进视觉科学领域强大的卓越中心的发展。凭借我们现有的优势 和研究基础设施网络，加上本 VS-CoBRE 中提出的举措，包括指导 在我们四名有前途的初级 PL 中，我们完全有能力实现我们的目标。建立一个中心 卓越为整合整个校园的努力提供了场所，包括 NIGMS 支持的活动 包括西弗吉尼亚州 CTSI 和其他 CoBRE，眼科和视觉科的临床企业 由生物化学、神经科学、生物学、 和生物医学工程项目。 VS-CoBRE 将围绕一个共同的目标将视觉科学家联合起来 主题，改善智力环境，培育交叉合作。当调查人员 提议通过此赠款支持通过获得 R01 同等奖项来实现独立，我们将利用 VS-CoBRE 招募更多从事视觉科学工作的初级科学家。核心设施 CoBRE 支持的研究基础设施也将使我们的研究人员能够产生研究成果 这将转化为患者，推动我们实现减轻视力障碍负担的最终目标 及其在阿巴拉契亚地区、全国和全世界的合并症。