IGF::OT::IGFEMMES NEIS-V

基本信息

批准号：
10329834
负责人：
KERI HAMMEL
金额：
$ 731.59万
依托单位：
THE EMMES COMPANY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-11-01 至 2021-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10329834
关键词：
Acquired Immunodeficiency Syndrome Age related macular degeneration Anophthalmos Area Analyses Autologous Transplantation Bilateral COVID-19 Case-Control Studies Cell Line Clinical Clinical Research Clinical Trials Cognition Collection Coloboma Contractor Contracts Cost Effectiveness Analysis Cross-Sectional Studies DNA Repository Dark Adaptation Data Analyses Databases Diabetic Retinopathy Diagnosis Disease Early treatment Electrooculogram Eligibility Determination Enrollment Epidemiology Esthesia Evaluation Evaluation Studies Extramural Activities Eye Eye diseases Family Follow-Up Studies Gene Transfer Generations Genes Genetic Genotype Healthcare Human Immunosuppression Inflammation Mediators Inflammatory Inherited Institutes Intramural Research Investigation Liquid substance Longterm Follow-up Measures Mediating Medicare Metformin Microglia Microphthalmos Minocycline Molecular Mutation Natural History Observational Study Oral Outcome Outcome Measure Outcomes Research Participant Pathogenesis Patient Monitoring Patients Perception Phase Phase I/II Trial Phenotype Pilot Projects Platelet-Derived Growth Factor Proteome Quality-of-Life Assessment Randomized Research Retina Retinal Diseases Retinal Vein Occlusion Retinitis Pigmentosa Safety Secondary to Somatic Cell Specific qualifier value Structure of retinal pigment epithelium Supplementation Surveys Survivors Telangiectasis Testing Toxic effect Type 7 Spinocerebellar Ataxia Uveitis Vascular Endothelial Growth Factors Vertebrate Photoreceptors Viral Vision Vision Disorders Visual Motor Coordinations Von Hippel-Lindau Syndrome Work X-Linked Retinoschisis active method adalimumab adaptive optics age related biobank central retinal vein occlusion data management design disorder of macula of retina economic evaluation efficacy evaluation exome follow-up genome sequencing geographic atrophy induced pluripotent stem cell inhibitor/antagonist macula macular dystrophy microbiome open label optical imaging patient safety preclinical study prospective randomized placebo controlled trial ranibizumab repository retinal imaging retinyl palmitate safety study sham-controlled study virtual reality whole genome

项目摘要

This contract is designed to attain extramural support for developing, designing, interpreting, and evaluating clinical trials, epidemiologic and natural history studies. In addition, it will provide for outcomes research involving eye diseases and visual disorders and some preclinical studies. The focus shall be on the design of studies and the collection, analysis, and interpretation of data emanating from these studies, as well as support, and monitoring patient safety and follow-up. Contractor shall also provide analytical and data management support, as described in the work statement, for specified clinical research data bases, cost-effectiveness and economic analyses, quality of life assessment and outcomes research. This will include, but not be limited to, the following areas: analysis of Medicare and other health care databases; evaluation of existing NEI databases such as, centralized NEI Intramural Research database, the Eye Disease Case Control Study, Early Treatment Diabetic Retinopathy Study, Framingham Eye Study, and intramural AIDS and uveitis databases.

该合同旨在为开发、设计、解释和评估临床试验、流行病学和自然史研究获得外部支持。此外，还将提供涉及眼部疾病和视觉障碍的结果研究以及一些临床前研究。重点应放在研究设计以及这些研究数据的收集、分析和解释，以及支持和监测患者安全和随访上。承包商还应为指定的临床研究数据库、成本效益和经济分析、生活质量评估和结果研究提供工作说明书中所述的分析和数据管理支持。这将包括但不限于以下领域：医疗保险和其他医疗保健数据库的分析；评估现有的 NEI 数据库，例如中央 NEI 校内研究数据库、眼病病例对照研究、早期治疗糖尿病视网膜病变研究、弗雷明汉眼科研究以及校内艾滋病和葡萄膜炎数据库。