Mentoring and Research in Patient-Oriented Integrative Medicine

以患者为中心的整合医学的指导和研究

基本信息

批准号：
10327635
负责人：
CHENCHEN WANG
金额：
$ 18.31万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-12-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10327635
关键词：
Acupuncture Therapy Affect Applications Grants Archives Authorship Award Bibliography Brain Childhood Chinese Traditional Medicine Chronic Chronic Fatigue Syndrome Clinical Clinical Research Clinical Sciences Clinical Trials Complementary Medicine Discipline Disease Progression Doctor&apos s Degree Dose Educational process of instructing Emotional Environment Environmental Risk Factor Epigenetic Process Ethics Family Fostering Foundations Funding Future Future Generations Goals Grant Health Health Promotion Healthcare Healthcare Systems Human Human Biology Individual Infrastructure Institutes Integrative Medicine Integrative Therapy Investigation Journals Massage Medical Medicine Mental Depression Mental Health Mental disorders Mentors Methodology Methods MicroRNAs Mid-Career Clinical Scientist Award (K24)Military Personnel Mind-Body Intervention Mission Modality Modeling Modern Medicine Morbidity - disease rate National Center for Complementary and Integrative Health Neurobiology Neurosciences Neurosciences Research Outcome Pain Pathway interactions Patients Peer Review Persian Gulf Syndrome Persistent pain Personal Satisfaction Persons Physicians Physiological Physiology Pilot Projects Politics Predisposition Progress Reports Psychology Publications Publishing Quality of life Records Regimen Research Research Personnel Research Project Grants Resources Rest Role Science Scientist Self Management Severities Stress Structure Symptoms Tai Ji Techniques Testing Therapeutic Time Traditional Medicine Training Translational Research United States Department of Veterans Affairs United States National Institutes of Health Universities Veterans Work body-mind career central sensitization chronic musculoskeletal pain chronic pain chronic pain management chronic pain patient clinical practice cognitive control combat comparative effectiveness study cost cost effective disability effective therapy evidence base experience experimental study fibromyalgia patients healing health care service utilization improved innovation interdisciplinary approach lifestyle intervention medical schools military veteran multidisciplinary neurobiological mechanism next generation novel nutrition opioid use osteoarthritis pain patient oriented patient oriented research professor programs public health relevance response social social factors sperm cell symptom management symptomatic improvement theories tool

项目摘要

MENTORING AND RESEARCH IN PATIENT-ORIENTED INTEGRATIVE MEDICINE The renewal Midcareer K24 Award is for Dr. Chenchen Wang to continue her mentoring of the next generation of physician-scientists and to contribute to patient-oriented Integrative Medicine research. Dr. Wang is Professor at Tufts University School of Medicine and Director of the Center for Complementary and Integrative Medicine and holds a strong record of research, publication, and mentoring. Her long-term goal is to advance the science of Integrative Medicine to promote health and healing. Her immediate goals are to obtain protected time to expand and strengthen her innovative, multi-method, and multidisciplinary translational research and mentoring programs for chronic disabling conditions. In the First Four Years of the K24, the PI has completed four major NIH-funded clinical trials studying comparative effectiveness of mind-body interventions for chronic musculoskeletal pain, developing integrative treatment approaches in military and veterans populations, and provided groundbreaking evidence on neurobiological and physiological responses to mind-body interventions. In this period, the PI published 61 articles, 8 as first author and 53 as senior author. The PI and her mentored team also received a new R01-like grant from the U.S. Department of Veterans Affairs to investigate the efficacy of a mind-body intervention for veterans suffering with Gulf War Illness. During the initial K24 period, she has been primary or co-primary mentor for 23 trainees with doctoral degrees. Her trainees authored 41 first-authored peer-reviewed publications and had 64 co-authorships. Ten of her trainees have their own NIH or other career grants. Dr. Wang’s multidisciplinary mentoring program, as well as her expertise on mind-body interventions, has been fully integrated into the research and teaching infrastructure of the Tufts Clinical and Translational Science Institute. With access to these outstanding resources and a long-recognized diverse training environment, her selected mentees will continue to obtain training in the rigorous scientific methodology, integrity, ethics, and grant applications necessary to stimulate high-quality, translational, patient-oriented research. The goal of this proposed K24 renewal is to build upon previous and current findings of the PI’s NIH-funded studies to: 1) expand and evaluate translational Integrative Medicine research for chronic disabling conditions in order to inform and benefit medical practice; 2) advance fundamental neuroscience and human biology research to understand the mechanisms of mind-body approaches, with the goal to improve chronic pain management; 3) identify critical unmet needs of novel effective therapies for managing symptoms; and 4) further strengthen the comprehensive interdisciplinary mentoring plan and extend opportunities to new scientists to guide future generations of Integrative Medicine researchers. This K24 renewal will therefore promote multidisciplinary patient-oriented research for the next generation of investigators in order to substantially advance the science on complementary and integrative medicine and contribute to the health, healthcare, and well-being for all.

以患者为中心的综合医学的指导和研究更新的Midcareer K24奖是为了让王晨晨博士继续指导下一代王博士是一名医师科学家，致力于为以患者为中心的整合医学研究做出贡献。塔夫茨大学医学院教授兼补充与整合中心主任她在医学领域拥有丰富的研究、出版和指导记录，她的长期目标是不断进步。她的近期目标是获得保护，促进健康和康复的综合医学科学。有时间扩大和加强她的创新、多方法、多学科转化研究和针对慢性残疾状况的指导计划。在 K24 的前四年中，PI 完成了 NIH 资助的四项主要临床试验身心干预对慢性肌肉骨骼疼痛的比较有效性，发展综合性军人和退伍军人群体的治疗方法，并提供了开创性的证据在此期间，PI 发表了 61 项对身心干预的神经生物学和生理反应。文章中，8 篇为第一作者，53 篇为高级作者。PI 和她的指导团队也获得了新的 R01 类。美国退伍军人事务部拨款用于调查身心干预的功效患有海湾战争疾病的退伍军人在最初的 K24 期间，她一直是主要或共同主要的。她的导师是 23 名拥有博士学位的学员的导师，她的学员撰写了 41 篇第一作者的同行评审论文。她的 10 名学员拥有自己的 NIH 或其他职业资助。王女士的多学科指导计划以及她在身心干预方面的专业知识得到了广泛认可。完全融入塔夫茨临床和转化科学的研究和教学基础设施凭借这些优秀的资源和长期认可的多元化培训环境，她选定的受训者将继续接受严格的科学方法、诚信、道德和道德方面的培训刺激高质量、转化性、以患者为导向的研究所需的拨款申请。拟议的 K24 更新的目标是建立在 PI 的 NIH 资助的先前和当前发现的基础上研究目的：1）扩大和评估慢性致残性疾病的转化整合医学研究为医学实践提供信息并使其受益；2）推进基础神经科学和人类生物学的发展；研究了解身心方法的机制，目标是改善慢性疼痛管理；3）确定治疗症状的新型有效疗法的关键未满足需求； 4）进一步加强全面的跨学科指导计划，并为新人提供机会因此，K24 的更新将由科学家指导未来的综合医学研究人员。促进下一代研究人员以患者为中心的多学科研究，以便大幅推进补充和综合医学科学并为健康做出贡献，医疗保健和所有人的福祉。