Optimizing interventions to mitigate schistosomiasis-related morbidity among pregnant women and children

优化干预措施，降低孕妇和儿童血吸虫病相关发病率

基本信息

批准号：
10326849
负责人：
JENNIFER F FRIEDMAN
金额：
$ 19.08万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-15 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10326849
关键词：
Address Age Anemia due to Chronic Disorder Apoptosis Area Award Birth Blood Centers of Research Excellence Child Collaborations Communicable Diseases Complex Data Data Set Development Discipline Doctor of Philosophy Dose Education Enrollment Equation Excision Faculty Fetal Growth Retardation Freezing Frequencies Funding Goals Grant Growth Health Helminths Hookworms Hospitals Housing Human Human Microbiome Immunologist Individual Infant Inflammation Insulin Intervention K-Series Research Career Programs Letters Low Birth Weight Infant Malnutrition Measures Mediating Mentors Mentorship Methodology Modeling Morbidity - disease rate Mothers Multi-Institutional Clinical Trial Neurocognitive Neurocognitive Deficit Newborn Infant Nutritional Nutritional status Outcome Parasitic Diseases Pathway interactions Pharmaceutical Preparations Phase Philippines Physicians Placenta Placental microbiome Policies Praziquantel Pregnancy Pregnant Women Publications Research Research Personnel Ribosomal DNA Risk Sampling Schistosomiasis Science Scientist Secure Serum Signal Transduction Site Source Sterility Techniques Time Training Translational Research Uganda United States National Institutes of Health Universities Work Writing absorption base career development cohort early childhood global health gut health helminth infection immune activation infant outcome interdisciplinary approach interest international center microbial microbiome patient oriented research pharmacokinetics and pharmacodynamics placental morphology prenatal programs recruit reproductive skill acquisition skills treatment program

项目摘要

Project Summary This renewal application for a K24 seeks to continue to provide time for the candidate, Jennifer Friedman, MD, PhD, to provide mentorship to junior faculty in patient oriented research (POR) with a focus on optimizing interventions for parasitic diseases among pregnant women and children. The second goal is to provide time for Dr. Friedman to further her own career development through a) pursuit of advanced education in Structural Equation Modeling and characterization of the human microbiome and b) leading policy changes to include pregnant women and young children in treatment programs for schistosomiasis. Dr. Friedman proposes to continue to mentor junior faculty and fellows conducting POR at the Center for International Health Research (CIHR). The Center is an outstanding model for interdisciplinary team science, where most faculty are physician-scientists and other scientists carry out translational research as an integral part of these teams. In the first phase of this K24, Dr. Friedman closely mentored five junior faculty at CIHR. Of these, four were recipients of Career Development Awards with Dr. Friedman as primary or co-mentor and the other was a target young investigator on a large training grant (Centers for Biomedical Research Excellence (COBRE)) in infectious diseases. In addition, one mentee (Levine) received his first independent grants (R03 and R01) in 2017 with grant writing mentorship provided by Dr. Friedman. The overarching scientific goal of this proposal is to advance studies elucidating mechanisms through which schistosomiasis contributes to environmental enteropathy, culminating in microbial translocation, systemic immune activation, and adverse pregnancy and nutritional outcomes. Dr. Friedman has two current R01s that provide outstanding opportunities for junior faculty to conduct POR in global health. The first is a longitudinal birth cohort (PIs Friedman, Gundogan) that has already enrolled N=400 pregnant women and is now following the newborns until age two. The second is a multi-site RCT (PIs Friedman, Bustinduy) examining optimal dose and dosing frequency of praziquantel for children under the age of four. Both grants provide both opportunities to conduct field work at sites with longstanding collaborations and will offer a wealth of well characterized data and samples to address the aims proposed in this K24 as well as other aims conceived of by mentees. They will also be able to engage in other NIH grants at CIHR with co-mentoring by Dr. Friedman and other faculty (see letters of support). Brown University affiliated hospitals provide a rich source of potential mentees from a range of Divisions housing junior faculty interested in conducting POR in infectious diseases. In addition, although there are numerous other training grants at Brown affiliates, there are two T32 awards, two COBRE awards, and one R25, which could specifically provide a pipeline for young investigators and co-funding in research areas of interest to Dr. Friedman.

项目概要 K24 的续签申请旨在继续为候选人 Jennifer Friedman 提供时间，医学博士、博士，为初级教师提供以患者为导向的研究 (POR) 的指导，重点是优化对孕妇和儿童寄生虫病的干预措施。第二个目标是提供时间弗里德曼博士通过 a) 追求结构学方面的高等教育来进一步促进自己的职业发展人类微生物组的方程建模和表征，以及 b) 主导政策变化，包括孕妇和幼儿参加血吸虫病治疗方案。弗里德曼博士建议继续指导在该中心进行 POR 的初级教员和研究员国际健康研究（CIHR）。该中心是跨学科团队科学的杰出典范，大多数教师都是医师科学家，其他科学家将转化研究作为一个整体进行这些团队的一部分。在 K24 的第一阶段，弗里德曼博士密切指导了 CIHR 的五名初级教师。的其中，四人获得了弗里德曼博士作为主要或共同导师的职业发展奖，另一位是获得大量培训补助金的目标年轻研究员（生物医学卓越研究中心）（COBRE））在传染病中。此外，一名受训者（Levine）获得了他的第一个独立资助（R03 和 R01）于 2017 年获得资助写作指导，由弗里德曼博士提供。该提案的总体科学目标是推进研究，通过以下方式阐明机制：血吸虫病会导致环境性肠病，最终导致微生物易位，全身免疫激活以及不良妊娠和营养结果。弗里德曼博士目前有两个 R01 为初级教师提供了在全球健康领域开展 POR 的绝佳机会。第一个是纵向出生队列（PIs Friedman、Gundogan）已经招募了 N=400 名孕妇，并且正在现在跟踪新生儿直到两岁。第二个是多中心随机对照试验（PIs Friedman、Bustinduy）四岁以下儿童吡喹酮的最佳剂量和给药频率。两项补助金均提供在长期合作的地点进行实地工作的机会，并将提供丰富的信息特征数据和样本，以解决本 K24 中提出的目标以及设想的其他目标由受训者。他们还将能够在弗里德曼博士的共同指导下参与 CIHR 的其他 NIH 资助和其他教员（参见支持信）。布朗大学附属医院提供了来自各个部门的丰富的潜在学员来源为有兴趣开展传染病 POR 的初级教师提供住宿。此外，虽然有布朗附属机构还有许多其他培训补助金，其中有两个 T32 奖项、两个 COBRE 奖项和一个 R25，它可以专门为年轻研究人员提供一个管道，并在以下研究领域提供共同资助弗里德曼博士感兴趣。