Does Biocompatibility Contribute to Transfusion-Related Adverse Effects?

生物相容性是否会导致输血相关的不良反应？

基本信息

批准号：
10321632
负责人：
Nikki Gillum Posnack
金额：
$ 67.74万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-01-15 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10321632
关键词：
Address Adoption Adverse effects Arrhythmia Atherosclerosis Autonomic Dysfunction Biocompatible Materials Blood Blood Transfusion Cardiac Cardiopulmonary Bypass Cardiovascular system Cartoons Cells Chemical Exposure Chemicals Childhood Clinical Communities Coupled Critical Illness Decision Making Development Devices Endocrine Disruptors Endocrine disruption Exposure to Extracorporeal Membrane Oxygenation Foundations Frequencies Future Health Heart Human Hypertension Impairment Incentives Incidence Infant Inflammatory Inherited Length of Stay Medical Medical Device Modeling Monitor Myocardial Infarction Neurologic Outcome Patients Preparation Procedures Property Publishing Reaction Risk Role Safety Sickle Cell Anemia Techniques Thalassemia Toxic effect Transfusion United States Xenobiotics adverse outcome base biomaterial compatibility clinical effect clinical investigation epidemiology study heart rate variability improved in vivo insight mortality neonate neurodevelopment patient population patient safety pediatric patients phthalates premature research study surface coating transfusion medicine virtual

项目摘要

Project Summary Nearly 15 million transfusions are performed in the United States each year, with approximately 425,000 units transfused to pediatric patients alone. Despite the frequency – transfusion procedures are not without risk. Blood transfusion complications may be attributed to heavy exposure to plastic devices, which are fabricated with chemicals that exert endocrine disrupting properties. The proposal's main hypothesis is that plastic devices are not universally biocompatible – and that local and systemic reactions to chemical contaminants contribute to transfusion-related complications. The proposal's objective is to assess whether medical device biocompatibility and chemical exposures are underlying contributors to cardiovascular and autonomic dysfunction. The proposal also aims to identify safer biomaterials, chemicals and/or surface coatings for transfusion devices and blood banking. In this proposal, we will build upon our preliminary studies to address three specific aims: 1) To define the extent to which biomaterial leaching and chemical exposure alters cardiovascular and autonomic function, using in vivo and whole heart models. 2) To determine if biocompatibility and incidental chemical exposures are correlated with cardiovascular and autonomic abnormalities in transfused pediatric patients. 3) To compare and contrast alternative biomaterials, chemicals and fabrication techniques in order to identify safer replacements for transfusion-related devices. The proposed application will quantify the role of biocompatibility and chemical leaching on cardiovascular and autonomic function – two targets that are highly susceptible to xenobiotic toxicity. If adverse outcomes are observed in the proposed study, it will pinpoint additional variables to monitor in future clinical investigations and epidemiological studies. Finally, this proposal aims to provide the foundation for objective decision making regarding the use of chemical additives with endocrine disrupting properties in medical device manufacturing by scientific, medical and regulatory communities. Results of the proposed studies can incentivize and accelerate the development and clinical adoption of alternative biomaterials, additives and/or fabrication techniques to improve transfusion patient safety.

项目概要美国每年进行近 1500 万次输血，约 425,000 单位尽管输血频率很高，但仅向儿童患者输血并非没有风险。输血并发症可能是由于大量接触塑料装置造成的，这些装置是用该提案的主要假设是塑料设备具有内分泌干扰特性。不具有普遍的生物相容性——并且对化学污染物的局部和全身反应会导致该提案的目的是评估医疗器械是否具有生物相容性。化学物质暴露是导致心血管和自主神经功能障碍的潜在因素。还旨在寻找用于输血装置和血液的更安全的生物材料、化学品和/或表面涂层在本提案中，我们将在初步研究的基础上实现三个具体目标：1) 定义银行业。生物材料浸出和化学品暴露改变心血管和自主神经功能的程度，使用体内和整个心脏模型 2) 确定生物相容性和偶然的化学暴露是否存在。与输血儿科患者的心血管和自主神经异常相关 3) 进行比较和比较。对比替代生物材料、化学品和制造技术，以确定更安全的替代品输血相关设备。拟议的应用将量化生物相容性和化学的作用。对心血管和自主神经功能的浸出——这两个目标极易受到外源性毒性的影响。如果在拟议的研究中观察到不良结果，它将指出未来需要监测的其他变量最后，本建议旨在为临床调查和流行病学研究提供基础。关于在医疗中使用具有内分泌干扰特性的化学添加剂的客观决策科学、医学和监管界的设备制造可以。激励和加速替代生物材料、添加剂和/或的开发和临床采用提高输血患者安全的制造技术。

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexyl phthalate.

增塑剂邻苯二甲酸二-2-乙基己酯的心脏抑制作用的证据。

DOI：
发表时间：
2023-12-21
期刊：
影响因子：
0
作者：
Swift, Luther M;Roberts, Anysja;Pressman, Jenna;Guerrelli, Devon;Allen, Samuel;Haq, Kazi T;Reisz, Julie A;D'Alessandro, Angelo;Posnack, Nikki Gillum
通讯作者：
Posnack, Nikki Gillum

Potential Consequences of the Red Blood Cell Storage Lesion on Cardiac Electrophysiology.

红细胞储存损伤对心脏电生理学的潜在影响。

DOI：
发表时间：
2020-11-03
期刊：
影响因子：
5.4
作者：
Reilly, Marissa;Bruno, Chantal D;Prudencio, Tomas M;Ciccarelli, Nina;Guerrelli, Devon;Nair, Raj;Ramadan, Manelle;Luban, Naomi L C;Posnack, Nikki Gillum
通讯作者：
Posnack, Nikki Gillum

Characteristics of Bisphenol Cardiotoxicity: Impaired Excitability, Contractility, and Relaxation.

双酚心脏毒性的特征：兴奋性、收缩性和松弛性受损。

DOI：
发表时间：
2022-03
期刊：
影响因子：
3.2
作者：
Cooper, Blake L;Posnack, Nikki Gillum
通讯作者：
Posnack, Nikki Gillum

Choice of experimental model determines translational impact: The link between bisphenol A and cardiotoxicity.

实验模型的选择决定了转化影响：双酚 A 与心脏毒性之间的联系。

DOI：
发表时间：
2023-04
期刊：
影响因子：
0
作者：
Cooper, Blake L;Posnack, Nikki Gillum
通讯作者：
Posnack, Nikki Gillum

Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.

小动物心脏电生理学和心律失常评估指南。

DOI：
发表时间：
2022-12-01
期刊：
影响因子：
0
作者：
Ripplinger, Crystal M.;Glukhov, Alexey V.;Kay, Matthew W.;Boukens, Bastiaan J.;Chiamvimonvat, Nipavan;Delisle, Brian P.;Fabritz, Larissa;Hund, Thomas J.;Knollmann, Bjorn C.;Li, Na;Murray, Katherine T.;Poelzing, Steven;Quinn, T. Alexander;Remme, Carol Ann;Rentschler, Stacey L.;Rose, Robert A.;Posnack, Nikki G.
通讯作者：
Posnack, Nikki G.