Advanced Materials to Improve Moisture Management for Prosthetic Socket Liners

先进材料可改善假肢接受腔衬垫的水分管理

• 批准号: 10316147
• 负责人: Clay Kelly
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10316147
• 关键词: Adsorption; Affect; Amputees; Back; Cellulose; Characteristics; Clinical; Collection; Coupled; Development; Devices; Diffuse; Diffusion; Engineering; Evaluation; Extravasation; Filler; Friction; Heel; Hydration status; Hydrophobicity; Hygiene; Infection; Limb Prosthesis; Limb structure; Link; Lower Extremity; Maintenance; Mechanics; Modernization; Molecular Weight; Natural regeneration; Participant; Patients; Performance; Physical therapy; Play; Polymers; Polyurethanes; Population; Production; Property; Prosthesis; Regimen; Rod; Role; Sampling; Shear Strength; Silicones; Skin; Stress; Suction; Suspensions; Sweat test; System; Technology; Testing; Tissues; Traction; Upper Extremity; Vacuum; Veterans; Walkers; Walking; Water; base; clay; clinical implementation; clinical practice; crosslink; design; diabetic; ethylene glycol; hydrophilicity; improved; mechanical properties; microbial; military veteran; nanocomposite; nanocrystal; polydimethylsiloxane; prevent; prosthetic socket; prototype; residual limb; skin damage; standard of care; uptake

In modern prosthetics a suction liner provides a mechanical connection to the rigid socket by “gripping” the residual limb of the patient by either skin traction or suction. Conventionally, liners are made from materials that are impermeable to water such as silicone and polyurethane. Prolonged moisture accumulation inside the liner adversely affects fit and contributes to issues such as maceration (tissue softening from constant water exposure), breakdown, and infection, as well as issues of comfort and hygiene.  Managing this issue could revolutionize the clinical implementation of this widely used suspension system. We propose to develop a new type of advanced-material prosthetic liner system that maintains skin traction and suction but also absorbs, wicks, channels, and manages the water from sweat. This material will improve clinical practice by providing a more stable, comfortable, and less problematic interface between the limb and socket. Our objective is to develop a highly cross-linked prototype hydrated material system, for use in place of the water-impermeable silicone liner, to maintain airless skin traction and suction while managing sweat and keeping a static volume in relation to water content. This new liner material will require the development of two advanced materials, a sweat- transporting medium incorporating silicone cellulose nanocrystal nanocomposites (CNCs), and a polymer/clay aerogel which can absorb and retain moisture until it is deliberately removed. Both of these materials will be developed and tested to optimize their mechanical and sweat-diffusion properties. Finally, these materials will be layered along with a third, sealant layer made of standard liner silicone into a three-layered prototype for further mechanical, sweat management, durability, and regeneration testing as well as hygiene examination coupled to functional evaluation of the material in a rigid  walking boot. Improving water management in this critical component will fundamentally improve standard of care for a large population of lower and upper limb amputees.

在现代假肢中，抽吸衬垫提供了与刚性假肢的机械连接。 通过皮肤牵引或抽吸来“夹住”患者的残肢。 通常，衬里由不透水的材料制成，例如 硅胶和聚氨酯内衬内长期积聚水分会产生不利影响。 影响贴合度并导致浸渍等问题（组织因持续软化而软化） 接触水）、故障和感染，以及舒适和卫生问题。 解决这个问题可能会彻底改变这种广泛使用的临床实施 悬挂系统。 我们建议开发一种新型先进材料假肢衬垫系统 保持皮肤的牵引力和吸力，同时也吸收、芯吸、引导和管理 这种材料将通过提供更稳定、更稳定的水来改善临床实践。 我们的目标是使肢体和接受腔之间的接口舒适且问题较少。 是开发一种高度交联的原型水合材料系统，用于现场使用 不透水硅胶衬里，保持无气皮肤牵引和吸力 同时控制出汗并保持与含水量相关的静态体积。 新的内衬材料将需要开发两种先进材料，一种是汗水- 含有硅纤维素纳米晶体纳米复合材料的传输介质 （数控系统），以及聚合物/粘土气凝胶，可以吸收和保留水分，直到它 这两种材料都将被有意地去除并进行测试以进行优化。 最后，这些材料将被分层。 连同由标准衬里硅胶制成的第三层密封剂层形成三层 用于进一步机械、汗水管理、耐用性和再生的原型 测试以及卫生检查以及刚性材料的功能评估 改善这一关键部分的水管理将从根本上改善。 提高大量下肢和上肢截肢者的护理标准。