Culturally relevant contributors to cognitive and MRI changes in older Latinos

老年拉丁裔认知和 MRI 变化的文化相关因素

• 批准号: 10316218
• 负责人: Melissa Lamar
• 金额: $ 74.18万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10316218
• 关键词: Acculturation; Address; Adopted; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Behavior; Blood Vessels; Brain; Cognition; Cognitive; Cohort Studies; Crime; Data; Demyelinations; Diabetes Mellitus; Family; Future; Goals; Health; High Prevalence; Hypertension; Impaired cognition; Individual; Informatics; Infrastructure; Intervention Studies; Investigation; Iron; Knowledge; Language; Latino; Latino Population; Link; Literature; Magnetic Resonance Imaging; Measures; Minority Groups; Modification; Motor; Neighborhoods; Nerve Degeneration; Outcome; Pattern; Population; Prevalence; Process; Public Health; Reaction Time; Research; Risk Factors; Sampling; Smoking; Social Environment; Societies; Study of Latinos; Time; Work; aging brain; brain magnetic resonance imaging; cardiovascular disorder risk; cognitive change; cohort; data acquisition; dementia risk; digital; experience; follow-up; health disparity; indexing; member; multimodal neuroimaging; multimodality; neuroimaging; perceived discrimination; preference; stressor; theories

PROJECT SUMMARY/ABSTRACT Latinos are one of the fastest growing minority populations in the US, and they are 1.5 times as likely to develop Alzheimer’s dementia as older non-Latino Whites. Culturally relevant factors such as acculturation, the process by which Latinos adapt to the US and potentially adopt its values and practices, may contribute to health disparities in brain aging and Alzheimer’s dementia in Latinos. While levels of acculturation have been linked to a number of health outcomes in Latinos, less work has been done in cognition and brain aging. Newer theories of acculturation suggest it is not a static, linear process but a dynamic exchange between Latinos and other members of society that emerges from and is reinforced by broader socioenvironmental determinants vital to a process now called ‘acculturation in context’ (AIC). Thus, in addition to traditional acculturation factors (e.g., language preference and/or years in the US), individual-level (e.g., perceived discrimination, family and/or cultural stressors) and neighborhood-level (e.g., crime rates) socioenvironmental determinants need to be integrated into research in older Latinos. We will incorporate advances in geospatial informatics to quantify neighborhood-level determinants of AIC, longitudinal multi-modal neuroimaging, and the digital capture of behavior in a well-characterized cohort of Latinos 60 years and older for the most comprehensive study of AIC as it relates to brain aging in Latinos. By 2030, the Latino population 65 and older will increase by ~225% compared to a 65% increase in non-Latino Whites; rates for Alzheimer’s dementias will also disproportionately increase for older Latinos. This R01, with its focus on AIC and brain aging in Latinos, may provide a more comprehensive understanding of the reasons for this disproportionate increase. To achieve the overall goal of the study – to investigate the relationship of AIC to changes in cognition and brain MRI indices in older Latinos and determine whether these factors affect the well-documented relationships between other risk factors and changes in cognition or brain MRI indices – we will conduct a comprehensive assessment of the AIC framework including the geocoding of neighborhood factors, repeat multi-modal MRI, and the digital capture of behavior in 350 older Latinos. We will leverage the infrastructure of two cohort studies at the Rush Alzheimer’s Disease Center to incorporate ongoing longitudinal data acquisition of cognition and other risk factors into this R01. When combined, this information will allow us to examine the relationship of AIC to change in cognition (Aim 1) and brain MRI indices (Aim 2) in older Latinos, and determine if levels of AIC modify the relationship of cardiovascular disease risk factor profiles to changes in cognition or brain MRI indices in this same population (Aim 3). Given that rates of Alzheimer’s dementia are disproportionately increasing for Latinos in the US, understanding modifiable contributors to this health disparity that may be specific to this population is critical.

项目概要/摘要 拉丁裔是美国增长最快的少数族裔之一，他们的可能性是美国的 1.5 倍 老年非拉丁裔白人患阿尔茨海默氏症的原因与文化相关，例如文化适应、文化适应等。 拉丁美洲人适应美国并可能采用其价值观和做法的过程可能有助于 拉丁美洲人的大脑老化和阿尔茨海默氏痴呆症的健康差异一直存在。 与拉丁美洲人的许多健康结果相关，在认知和大脑衰老方面所做的工作较少。 文化适应理论表明，这不是一个静态的、线性的过程，而是拉丁裔和拉丁裔之间的动态交换。 由更广泛的社会环境决定因素产生并得到强化的其他社会成员 因此，除了传统的文化适应因素之外，现在被称为“语境文化适应”（AIC）的过程也至关重要。 （例如，语言偏好和/或在美国的年限）、个人层面（例如，感知到的歧视、家庭 和/或文化压力）和社区层面（例如犯罪率）社会环境决定因素需要 我们将整合地理空间信息学的进步来量化。 AIC 的邻里级决定因素、纵向多模态神经影像以及数字捕获 对 60 岁及以上拉丁裔群体进行最全面的 AIC 研究，了解他们的行为 到 2030 年，65 岁及以上的拉丁裔人口将增加约 225%。 与非拉丁裔白人 65% 的增长相比，阿尔茨海默氏症痴呆症的发病率也将不成比例地增加 该 R01 重点关注拉丁美洲人的 AIC 和大脑老化，可能会提供更多信息。 全面了解这种不成比例增长的原因。 实现研究的总体目标——调查AIC与认知和认知变化的关系 老年拉丁美洲人的脑部 MRI 指数，并确定这些因素是否影响有据可查的 其他风险因素与认知或脑 MRI 指数变化之间的关系 – 我们将进行 AIC 框架的综合评估，包括邻里因素的地理编码，重复 我们将利用多模式 MRI 的基础设施，以及对 350 名拉丁裔老年人的行为进行数字捕捉。 拉什阿尔茨海默病中心的两项队列研究正在进行纵向合并数据采集 将认知和其他风险因素结合到此 R01 中，这些信息将使我们能够检查 AIC 与老年拉丁裔认知变化（目标 1）和脑 MRI 指数（目标 2）的关系，以及 确定 AIC 水平是否会改变心血管疾病危险因素谱与心血管疾病变化的关系 鉴于阿尔茨海默氏痴呆症的发病率是同一人群的认知或脑 MRI 指数（目标 3）。 美国拉丁裔的比例不成比例地增加，了解对这种健康的可改变的贡献者 该人群特有的差异至关重要。