Therapeutic interventions for post-stroke rehabilitation

中风后康复的治疗干预

基本信息

批准号：
10314765
负责人：
Helen M Bramlett
金额：
--
依托单位：
MIAMI VA HEALTH CARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-11-01 至 2025-10-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10314765
关键词：
Acute Adoptive Transfer Affect Animal Model Body Weight decreased Brain Brain hemorrhage Caring Cause of Death Cerebral Ischemia Clinic Clinical Clinical Trials Cognition Cognitive Communication Communities Data Deterioration Exercise Fatigue Female Fingerprint Frequencies Future Gait speed Genes Goals Hippocampus (Brain)Home Hormones Human Impaired cognition Infarction Inflammation Inflammatory Intervention Ischemic Brain Injury Ischemic Stroke Laboratories Laboratory Animals Link Mechanics Mediating Middle Cerebral Artery Occlusion Mitochondria Modeling Monitor Muscle Neurons Outcome Patients Physical Exercise Physical activity Physiological Pilot Projects Play Proteomics Quality of life Rattus Recovery Research Role Serum Skeleton Stroke Stroke prevention Temperature Testing Therapeutic Therapeutic Effect Therapeutic Intervention Tissues Transient Ischemic Attack Translating Treatment Efficacy United States Department of Veterans Affairs Vesicle Veterans Veterans Health Administration aged base behavioral study cost cytokine disability efficacy testing extracellular vesicles frailty glucose metabolism hormone therapy improved in vivo indexing insight middle age mitochondrial dysfunction mortality motor deficit motor learning natural hypothermia neurobehavior neuroinflammation neuronal survival novel novel therapeutic intervention out-of-hospital cardiac arrest post stroke post stroke cognitive impairment preclinical study response sex spinal cord and brain injury stroke model stroke outcome stroke patient stroke rehabilitation stroke risk stroke survivor thrombolysis transcriptional reprogramming transcriptomics translational goal vibration

项目摘要

Stroke remains one of the leading causes of death and disability in the USA. The principal objective of the current proposal is to test the efficacy of combined therapeutic hypothermia with whole body vibration on post-stroke cognitive improvement using a model of stroke in aged rats. There are three main types of stroke: transient ischemic attack, hemorrhagic stroke and acute ischemic stroke, with the latter constituting 87% of total stroke cases. Currently, the only clinical therapies available for acute ischemic stroke are thrombolysis (tPA) and mechanical endovascular recanalization, both of which have only limited applications in a small number of patients. Cognitive decline is one of the most significant problems affecting almost two-thirds of stroke survivors for up to 6 years post-stroke. Therefore, identifying novel neuroprotective strategies to improve post-stroke cognition remains a high priority. In animal models of stroke (transient middle cerebral artery occlusion – tMCAO), behavioral studies yield evidence of deficits in spatial, non-spatial, and motor learning. These deficits can be minimized in middle-aged rat models of stroke with noninvasive whole body vibration (WBV) therapy. Likewise, long-standing research from our laboratory shows that therapeutic hypothermia (TH) is a potent neuroprotective therapy in experimental cerebral ischemia with multiple effects at several stages of the ischemic cascade. The translational goal of our successful study will be to identify a novel therapeutic approach for stroke rehabilitation that can be moved quickly to testing in clinical trials.

中风仍然是美国死亡和残疾的主要原因之一。目前的建议是测试低温治疗与全身振动相结合的疗效使用老年大鼠中风模型进行中风后认知改善主要分为三种类型。中风：短暂性脑缺血发作、出血性中风和急性缺血性中风，后者构成目前，治疗急性缺血性中风的唯一临床疗法是中风病例总数的 87%。溶栓（tPA）和机械血管内再通术，这两种方法的作用都有限。在少数患者中的应用认知能力下降是最重要的问题之一。几乎三分之二的中风幸存者在中风后长达六年内都受到影响，因此，确定新颖的。在动物模型中，改善中风后认知的神经保护策略仍然是重中之重。中风（短暂性大脑中动脉闭塞 – tMCAO），行为研究得出缺陷证据在中年大鼠模型中，这些缺陷可以最小化。同样，长期的研究也表明，通过无创全身振动（WBV）疗法来治疗中风。我们实验室的研究表明，治疗性低温（TH）是一种有效的神经保护疗法实验性脑缺血在缺血级联的几个阶段具有多种效应。我们成功研究的转化目标将是确定一种新的中风治疗方法康复可以快速转移到临床试验中进行测试。