MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS

发育细胞相互作用的分子基础

• 批准号: 2200262
• 负责人: PETER J BRYANT
• 金额: $ 65.9万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2200262
• 关键词: cell cell interaction; developmental genetics; gene expression; histogenesis

A Program Project will be established in order to support an interactive program of research dedicated to understanding the molecular mechanisms of the cell interactions that control development. The cell interactions controlling cell proliferation will be investigated by a molecular analysis of a cell-proliferation control gene in Drosophila which encodes a cell adhesion molecule, and by studying the relationship between adhesion and proliferation of imaginal disc cells in vitro using a new culture system. Several genes required for the cell interactions that control cell and tissue polarity will be investigated at the genetic and molecular levels in Drosophila. Genes involved in the cell interactions governing head and foot formation in hydra will be isolated and characterized, their expression patterns studied, and their functions investigated in transgenic animals. The Project will support a Research Core Unit for antibody production, confocal microscopy, and image analysis which will be used by all of the component projects. The work will contribute to our understanding of the molecular mechanisms controlling normal development and regeneration as well as the defects in cell interaction mechanisms that underlie birth defects and cancer.

将建立一个计划项目以支持互动 致力于了解分子机制的研究计划 控制发育的细胞相互作用。 细胞相互作用 将通过分子分析研究控制细胞增殖 果蝇中编码细胞的细胞增殖控制基因 粘附分子，并通过研究粘附与 使用新的培养系统体外培养成虫盘细胞。 控制细胞和细胞相互作用的细胞相互作用所需的几个基因 组织极性将在遗传和分子水平上进行研究 果蝇。 参与细胞相互作用的基因控制头部和 水螅足的形成将被分离和表征，它们 研究表达模式及其在转基因中的功能 动物。 该项目将支持抗体研究核心单位 生产、共焦显微镜和图像分析，这些将被使用 所有组件项目。 这项工作将有助于我们 了解控制正常发育的分子机制 和再生以及细胞相互作用机制的缺陷 是出生缺陷和癌症的根源。