UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement

加州大学旧金山分校斯坦福子宫内膜异位症发现、创新、培训和社区参与中心

基本信息

批准号：
10308246
负责人：
LINDA C GIUDICE
金额：
$ 144.78万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10308246
关键词：
Adaptive Immune System Address Affect Age Animal Model Area Aromatase Inhibitors Autoimmune Awareness Biological Markers Cardiovascular Diseases Cells Characteristics Chronic Cicatrix Classification Clinical Clinical Data Collaborations Communities Community Outreach Complex Computational Science Contraceptive Agents Coupled DNA Library Data Databases Diagnosis Diagnostic Discipline Disease Disease Management Disease stratification Dysmenorrhea Ecology Education Education and Outreach Endometrial Endometrium Environment Estradiol Estrogens Etiology Excision Fatigue Fertility Fostering Functional disorder GNRH1 gene Genetic Genomics Goals Health Health Expenditures Health Professional Heterogeneity Hormonal Human Immunologics Immunology Incidence Infectious Agent Infertility Inflammation Inflammatory Inflammatory Response Informatics Institution Lesion Life Machine Learning Malignant - descriptor Malignant Neoplasms Medical Mental Depression Mentors Mentorship Multiomic Data Non-Malignant Non-Steroidal Anti-Inflammatory Agents Operative Surgical Procedures Organ Outcome Pain Pain management Pathogenesis Pathology Patient-Focused Outcomes Pelvic Pain Pelvis Peritoneum Personal Satisfaction Pharmaceutical Preparations Phenotype Positioning Attribute Pregnancy Outcome Proteomics Quality of life Recurrence Research Research Personnel Research Project Grants Resolution Resources Risk Science Scientist Severities Steroids Students Surgeon Symptoms Systems Biology Technology Teenagers Tissue Banks Tissues Training Transcend United States National Institutes of Health Universities Uterus Validation Viral Woman Women&apos s Health analog biological specimen archives career career development chronic pelvic pain clinical care clinical phenotype clinically relevant community engagement comorbidity diagnostic biomarker disease classification disease diagnosis disease heterogeneity disease phenotype diversity and inclusion drug discovery drug repurposing economic impact endometriosis girls health disparity health economics human tissue improved innovation interdisciplinary collaboration member metabolomics minimally invasive multidisciplinary multiple omics next generation novel novel therapeutic intervention novel therapeutics pain relief pain symptom persistent organic pollutants phenotypic data precision medicine programs reproductive response response biomarker side effect student training systemic inflammatory response technological innovation therapeutic biomarker transcriptomics treatment response

项目摘要

ABSTRACT - OVERALL Endometriosis is a chronic, debilitating estrogen-dependent disease wherein tissue similar to the uterine lining (endometrium) is found mainly on pelvic tissues and organs where it causes an inflammatory response, scarring, pelvic pain, and infertility. It affects millions of reproductive age women and severely impacts quality of life and professional life, and has a huge health economic impact of about $69B annually in the U.S. While its etiology is uncertain, profound dysfunction of the innate and adaptive immune systems is associated with inefficient lesion clearance and pelvic and systemic inflammation. The heterogeneity of endometriosis lesions and disease phenotypes is reflected in variable pain symptom presentations, unpredictable fertility potential, uncertain disease pathophysiology, and unpredictable responses to medical therapies, symptom and disease recurrence after surgical resection, and risks for co-morbidities. Clinical classifications of endometriosis are maladapted to the heterogeneity of disease expression, and thus efficient treatments for associated pain symptoms are lacking. Herein, our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (“ENACT”) proposes a comprehensive systems biology and precision medicine approach to endometriosis. We propose to study endometriosis unmet needs and challenges through transdisciplinary collaboration and scientific and technologic innovations, integrating multi-omics data to dissect endometriosis disease mechanisms, identify phenotypic and environmental disease signatures, develop accurate disease stratification and diagnosis, and identify novel and repurposed drug classes to ameliorate pain symptoms. To achieve these goals, our Center is comprised of 3 independent and interactive projects and 2 Cores, focused on the central theme of Endometriosis Precision Medicine. Project 1 will focus on underlying immunological mechanisms in endometriosis pathogenesis and pathophysiology. Project 2 will address developing a multi- omic disease classification that will inform diagnostic strategies, and Project 3 will leverage existing and newly generated large-scale omic data to identify and validate new therapeutic interventions. Our long-standing Human Endometrial Tissue and DNA Bank and REDCap database and ongoing accruals with our collaborating network of surgeons will be a major resource for this Center's project. The Center will have an Administrative Core and an Education and Community Outreach Core that will engage students from the Bay Area in our research programs and empower women in our community and address health disparities associated with endometriosis. To achieve these goals, we have assembled a multi-disciplinary team of investigators at UCSF and Stanford University, many of whom are new to endometriosis research, as well as educators, trainees, and community representatives who are all committed to improve the lives of women and teen girls with endometriosis. Integrating multiple disciplines, fostering collaborations among those who are new to endometriosis, training the next generation and partnering with our community are key to the outcomes and impact of our Endometriosis Center.

摘要 - 总体子宫内膜异位症是一种慢性、使人衰弱的雌激素依赖性疾病，其组织类似于子宫内膜（子宫内膜）主要存在于盆腔组织和器官中，引起炎症反应、疤痕、它影响着数百万育龄妇女，严重影响生活质量和不孕症。职业生涯，并且在美国每年产生约 $69B 的巨大健康经济影响，而其病因是先天性和适应性免疫系统的不确定的、严重的功能障碍与低效病变有关子宫内膜异位症病变和疾病的异质性。表型反映在不同的疼痛症状表现、不可预测的生育潜力、不确定疾病病理生理学，以及对药物治疗、症状和疾病复发的不可预测的反应手术切除后，子宫内膜异位症的临床分类不适应。疾病表现的异质性，因此缺乏对相关疼痛症状的有效治疗。在此，我们的加州大学旧金山分校斯坦福子宫内膜异位症发现、创新、培训和社区中心 Engagement（“ENACT”）提出了一种全面的系统生物学和精准医学方法我们建议通过跨学科研究子宫内膜异位症未满足的需求和挑战。合作与科技创新，整合多组学数据剖析子宫内膜异位症疾病机制，识别表型和环境疾病特征，开发准确的疾病分层和诊断，并确定新的和重新利用的药物类别以改善疼痛症状。为了实现这些目标，我们的中心由 3 个独立的互动项目和 2 个核心组成，专注于子宫内膜异位症精准医学项目1的中心主题将集中于基础免疫学。子宫内膜异位症发病机制和病理生理学的机制项目 2 将解决开发多因素的问题。组学疾病分类将为诊断策略提供信息，项目 3 将利用现有的和新的生成大规模组学数据来识别和验证我们长期存在的人类治疗干预措施。子宫内膜组织和 DNA 银行以及 REDCap 数据库以及我们合作网络的持续累积外科医生将成为该中心项目的主要资源。该中心将设有一个行政核心和一个管理中心。教育和社区外展核心将使湾区的学生参与我们的研究项目赋予我们社区中的妇女权力并解决与子宫内膜异位症相关的健康差异。为了实现这些目标，我们在加州大学旧金山分校和斯坦福大学组建了一个由多学科研究人员组成的团队，其中许多人其中包括子宫内膜异位症研究的新手，以及教育工作者、学员和社区代表所有人都致力于整合多个学科来改善患有子宫内膜异位症的妇女和少女的生活，促进子宫内膜异位症新手之间的合作，培训下一代并建立伙伴关系与我们社区的合作是子宫内膜异位症中心取得成果和影响的关键。